2026-06-13T05:04:25Zhttps://api.repository.cam.ac.uk/server/oai/rioxx

oai:www.repository.cam.ac.uk:1810/3278752026-02-01T14:21:48Zcom_1810_229649com_1810_751com_1810_256067col_1810_368714

Abstract Many national governments have incorporated nature‐based solutions (NbS) in their plans to reduce net greenhouse gas emissions. However, uncertainties persist regarding both feasibility and consequences of major NbS deployment. Using the United Kingdom as a national‐level case study, we examined the potential contribution of three terrestrial NbS: peatland restoration, saltmarsh creation and woodland creation. While there is substantial political and societal interest in these three NbS, they also have strong potential for competition with other land uses, which will be a critical barrier to substantial deployment. We conducted a national mapping exercise to assess the potential area available for woodland creation. We then assessed the combined climate change mitigation potential to 2100 for the three NbS options under a range of ambition levels. In line with the most ambitious targets examined, 2 Mha of land is potentially available for new woodland. However, climate change mitigation benefits of woodland are strongly dependent on management choices. By 2100, scenarios with a greater proportion of broadleaved woodlands outsequester non‐native conifer plantations, which are limited by regular timber harvesting. Peatland restoration offers the greatest mitigation per unit area, whilst the contribution from saltmarsh creation is limited by the small areas involved. Overall, the contribution of these NbS to the United Kingdom’s net zero emissions target is relatively modest. Even with the most ambitious targets considered here, by 2100, the total cumulative mitigation from the three NbS is equivalent to only 3 years' worth of UK emissions at current levels. Policy implications . Major deployment of nature‐based solutions (NbS) is possible in the United Kingdom but reaching ‘net zero’ primarily requires substantial and sustained reductions in fossil fuel use. However, facilitating these NbS at the national scale could offer many additional benefits for people and biodiversity. This demands that policy‐makers commit to a UK‐wide strategic approach that prioritises the ‘nature’ aspect of NbS. In the push to reach ‘net zero’, climate change mitigation should not be used to justify land management practices that threaten biodiversity ambitions. https://www.repository.cam.ac.uk/handle/1810/327875 eng https://doi.org/10.17863/CAM.75329 https://www.repository.cam.ac.uk/bitstreams/f0108058-6988-4330-b3eb-673a946823b9/download 0021-8901 4102 Ecological Applications 41 Environmental Sciences 13 Climate Action 15 Life on Land The potential contribution of terrestrial nature‐based solutions to a national ‘net zero’ climate target http://purl.org/coar/resource_type/c_6501 Bradfer‐Lawrence, Tom Finch, Tom Bradbury, Richard B Buchanan, Graeme M Midgley, Andrew Field, Rob H https://doi.org/10.1111/1365-2664.14003 2021-11 Wiley 2021-09-10

oai:www.repository.cam.ac.uk:1810/2437572025-12-19T17:56:22Zcom_1810_225220com_1810_224350com_1810_224349com_1810_256063col_1810_243756

This collection contains two videos. The footage was shot over four days from January 1-4, 2009, and depicts a temple consecration ritual in Liugou Township, Jishishan County, Gansu Province, PR China. The main ritual practitioners are fashi, folk Daoist practitioners. http://www.dspace.cam.ac.uk/handle/1810/243757 other https://www.repository.cam.ac.uk/bitstreams/cffcf551-50f0-4b37-9de1-669ae890b5e5/download https://www.repository.cam.ac.uk/bitstreams/3f766cab-a7d6-4f10-a3db-64f020b0cfec/download Oral Literature Oral Tradition Linguistic Anthropology Gansu fashi Daoism Jishishan Fashi 01 http://purl.org/coar/resource_type/c_12ce Wen Xiangcheng 2009-01 World Oral Literature Project 2012-09-19

oai:www.repository.cam.ac.uk:1810/2484072025-12-19T17:56:23Zcom_1810_221736com_1810_34581com_1810_229649com_1810_751com_1810_256067col_1810_239063col_1810_265264

OBJECTIVE: This review explored whether cardiorespiratory fitness or physical activity act as either confounders or effect modifiers of the relationship between adiposity markers and all-cause mortality in older adults. METHODS: Systematic searches were carried out to identify observational studies that examined the association of adiposity markers (BMI, waist circumference, and waist-hip ratio) with all-cause mortality in adults aged ≥ 60 which took into account cardiorespiratory fitness or physical activity. Data from each included study was analyzed to produce a graphical representation of this relationship. RESULTS: Fourteen of the fifteen identified studies found that increasing BMI had a non-positive association with all-cause mortality, with persistence of the obesity paradox despite adjustment for physical activity or cardiorespiratory fitness. Physical activity measurement methods were all subjective and often unvalidated. The two studies stratifying for cardiorespiratory fitness did not find that fitness had a significant impact on the relationship between excess adiposity and mortality but found that overweight and fit people had better survival than normal-weight unfit people, CONCLUSIONS: The predominant use of poor physical activity measurement suggests that studies are currently not adequately accounting for possible physical activity confounding. More studies are needed for addressing the modification of the relationship between adiposity markers and mortality by cardiorespiratory fitness. https://www.repository.cam.ac.uk/handle/1810/248407 eng https://www.repository.cam.ac.uk/bitstreams/0b4d4162-2d38-497d-b75a-0d877869d21d/download 1930-7381 Adiposity Aged Body Mass Index Cause of Death Female Health Status Humans Male Middle Aged Motor Activity Obesity Obesity, Morbid Physical Fitness Risk Assessment Waist Circumference Waist-Hip Ratio The associations of "fatness," "fitness," and physical activity with all-cause mortality in older adults: A systematic review. http://purl.org/coar/resource_type/c_6501 2015-05-12 Yerrakalva, Dharani https://orcid.org/0000-0002-5129-290X Mullis, Ricky https://orcid.org/0000-0002-9531-0268 Mant, Jonathan https://doi.org/10.1002/oby.21181 2015-10 Wiley 2015-06-10

oai:www.repository.cam.ac.uk:1810/4002042026-03-20T07:31:38Zcom_1810_751com_1810_256067col_1810_294790

Parkinson's disease (PD) is a debilitating neurodegenerative condition that results in a loss of mobility and muscle control. A neuropathological hallmark of PD is the presence of aberrant inclusions, known as Lewy pathology, of which α-synuclein (α-Syn) is a major component. The accumulation of α-Syn may be due to an imbalance in the proteostasis system regulating α-Syn. To investigate this hypothesis, we delineated the proteostasis network (PN) of α-Syn in the human substantia nigra at the proteomic and transcriptomic level. We then defined an α-Syn proteostasis activity score (PAS) that quantifiably describes the relative activity of the α-Syn PN in promoting or inhibiting α-Syn aggregation. We report a corresponding PAS signature indicative of disease state, age-of-death in PD patients, and brain regional vulnerability to α-Syn aggregation in PD and healthy brains. After establishing the relevance of our network to PD, we developed a transcriptome-derived network model as an operational digital twin of the α-Syn PN in human substantia nigra cells from single-cell data and used it to prioritize candidate targets for PD. We then further showed the application of the α-Syn PN toward facilitating drug repurposing. Overall, this proof-of-concept study illustrates how our computational framework can identify and prioritize putative therapeutic targets and repurposing candidates for PD, providing testable hypotheses for experimental validation. https://www.repository.cam.ac.uk/handle/1810/400204 eng https://www.repository.cam.ac.uk/bitstreams/4255a9c6-a4e1-4457-b5f8-d4a058ac88eb/download https://www.repository.cam.ac.uk/bitstreams/10ad7733-6727-4621-856e-5f54969ce183/download https://www.repository.cam.ac.uk/bitstreams/97a28dc6-d5d3-47af-8b59-49b064b546a3/download 0027-8424 Parkinson’s disease alpha-synuclein protein homeostasis Humans alpha-Synuclein Parkinson Disease Proteostasis Substantia Nigra Transcriptome Proteomics Aged Male Protein Aggregation, Pathological Female The α-synuclein proteostasis network and its translational applications in Parkinson's disease. http://purl.org/coar/resource_type/c_6501 2026-01-08 https://orcid.org/0000-0002-5169-6672 Lim, Christine M https://orcid.org/0000-0002-3616-1610 Vendruscolo, Michele https://doi.org/10.1073/pnas.2513317123 10059436 10061100 2026-03-24 Proceedings of the National Academy of Sciences 2026-03-16

oai:www.repository.cam.ac.uk:1810/3332842025-12-19T17:56:26Zcom_1810_751com_1810_256067col_1810_294790

Abstract Large earthquakes transfer stress from the shallow lithosphere to the underlying viscoelastic lower crust and upper mantle, inducing transient creep during the postseismic interval. Recent experiments on olivine have provided a new rheological model for this transient creep based on the accumulation and release of back stresses among dislocations. Here, we test whether natural rocks preserve dislocation‐induced stress heterogeneity consistent with the back‐stress hypothesis by mapping olivine from the palaeosubduction interface of the Oman‐UAE ophiolite with high‐angular resolution electron backscatter diffraction. The olivine preserves heterogeneous residual stresses that vary in magnitude by several hundred megapascals over length scales of a few micrometers. Large stresses are commonly spatially associated with elevated densities of geometrically necessary dislocations within subgrain interiors. These spatial relationships, along with characteristic probability distributions of the stresses, confirm that the stress heterogeneity is generated by the dislocations and records their long‐range elastic interactions. Images of dislocations decorated by oxidation display bands of high and low dislocation density, suggesting that dislocation interactions contributed to the organization of the substructure. These results support the applicability of the back‐stress model of transient creep to deformation in the mantle portion of plate‐boundary shear zones. The model predicts that rapid stress changes, such as those imposed by large earthquakes, can induce order‐of‐magnitude changes in viscosity that depend nonlinearly on the stress change, consistent with inferences of mantle rheology from geodetic observations. Plain Language Summary Large earthquakes are generated in relatively cold and brittle rocks but also change the stresses acting on hotter rocks beneath the fault zone. These stress changes cause flow of the hot rocks in the Earth's upper mantle. Both laboratory experiments and observations of deformation at Earth's surface indicate that the viscosity of mantle rocks typically increases by orders of magnitude over the initial increments of deformation after an earthquake. However, the microscale processes that cause this viscosity evolution remain unclear. Recent laboratory experiments suggest that the viscosity evolution may be caused by elastic interactions among linear defects, dislocations, in the crystal lattice of the mineral olivine. Here, we test the relevance of this model to natural rocks by assessing whether the stresses that generate elastic interactions among dislocations are preserved in rocks from Earth's mantle that have been brought to the surface by the motion of tectonic plates. The new observations reveal significant stresses, imparted by dislocations, within individual grains of olivine. This finding supports the relevance of the laboratory‐derived model, which in turn allows the model to be used to predict the magnitude of viscosity changes affecting similar rocks in Earth's mantle. Key Points Olivine from Oman–UAE ophiolite preserves significant stress heterogeneity imparted by dislocations The stress heterogeneity supports a recent model for transient creep based on elastic interactions among dislocations The dislocation‐interaction model predicts order‐of‐magnitude changes in mantle viscosity due to earthquake loading https://www.repository.cam.ac.uk/handle/1810/333284 eng https://doi.org/10.17863/CAM.80707 https://www.repository.cam.ac.uk/bitstreams/7f2cb58d-f5ca-4bdd-bcbf-a57af5dd85ba/download https://www.repository.cam.ac.uk/bitstreams/950e3d03-4916-4bc0-9de5-c64527f274d5/download 2169-9313 37 Earth Sciences 3705 Geology 3706 Geophysics Transient Creep in Subduction Zones by Long‐Range Dislocation Interactions in Olivine http://purl.org/coar/resource_type/c_6501 2022-01-06 Wallis, David Sep, Mike Hansen, Lars N https://doi.org/10.1029/2021jb022618 MR/V021788/1 2022-01 American Geophysical Union (AGU) 2022-01-28

oai:www.repository.cam.ac.uk:1810/3016452025-12-19T17:56:27Zcom_1810_229649com_1810_751com_1810_256067col_1810_368714

This article examines the timing, scale and cause of transitions between different kinds of household energy use and especially heating in northern Sweden, with a focus on Norrbotten, between the late nineteenth century and 1970. It examines the related but separate histories of the adoption of new heating technologies, such as stoves and boilers, and the choice of fuels, such as firewood, coke, oil, and electricity, providing new data on the scale of consumption and timing of transition. The article demonstrates the important linkage between domestic fuel choice and labour markets, whether labour in farm and forest affecting stove use in the nineteenth century, or increased female labour participation outside the home and rising wages in the twentieth. The article goes beyond discussions of price and technology to consider the wider contexts of domestic use not only in terms of home life, but also industrial development and labour markets in northern Sweden. https://www.repository.cam.ac.uk/handle/1810/301645 eng https://doi.org/10.17863/CAM.48716 https://www.repository.cam.ac.uk/bitstreams/925ff598-1f7c-4c80-819e-4d4821dccc1a/download Heat in a cold climate. Household energy choices in the Scandinavian north, 1890-1970 http://purl.org/coar/resource_type/c_6501 2019-10-03 https://orcid.org/0000-0001-9878-6643 Warde, Paul Lindmark, Magnus via KTH Royal Institute of Technology 2020-02-03 2020-02-03

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https://www.repository.cam.ac.uk/handle/1810/395372 eng https://www.repository.cam.ac.uk/bitstreams/63545191-fa63-482a-9eea-674c948fda82/download https://www.repository.cam.ac.uk/bitstreams/fc255ca2-ad72-4312-a3c6-caea772007ea/download https://www.repository.cam.ac.uk/bitstreams/96b12c8c-fa0f-4284-a64c-95ba8c42bc58/download epidemiology NET adenocarcinoma appendix cancer Risk of secondary appendiceal tumours after colorectal cancer surgery: nationwide Swiss registry study http://purl.org/coar/resource_type/c_1843 2025-10-18 https://orcid.org/0000-0003-3381-9146 Meyer, Jeremy https://orcid.org/0000-0002-8275-2702 Meyer, Elin https://orcid.org/0000-0001-6717-8020 Fournier, Evelyne https://orcid.org/0000-0002-2856-5260 Liot, Emilie https://orcid.org/0000-0003-1423-6885 Meurette, Guillaume https://orcid.org/0000-0001-9196-9076 Koessler, Thibaud https://orcid.org/0000-0003-1652-4522 Toso, Christian https://orcid.org/0000-0001-6904-1255 Davies, Justin Wheeler, James https://orcid.org/0009-0002-1218-417X Staehelin, Katharina https://orcid.org/0000-0002-7847-7728 Rapiti, Elisabetta https://orcid.org/0000-0001-7421-6101 Ris, Frédéric https://orcid.org/0000-0003-2097-8674 Wildisen, Lea https://doi.org/10.1093/bjsopen/zraf147 2026-01-13 Oxford University Press 2026-01-13

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Work on calendar, referring to days of the week and months and their Muslim equivalent and other ways of calculating them http://www.dspace.cam.ac.uk/handle/1810/234648 jrb https://www.repository.cam.ac.uk/bitstreams/0eb0f3f0-d81a-4b93-8ec6-9863d86b997a/download https://www.repository.cam.ac.uk/bitstreams/3335ad4b-67ae-4c11-af8b-10105238e07b/download https://www.repository.cam.ac.uk/bitstreams/92f324a8-c305-4ed2-bd4c-745fee7ad808/download https://www.repository.cam.ac.uk/bitstreams/d467cf9a-36a8-4729-b106-f21213887d38/download https://www.repository.cam.ac.uk/bitstreams/e19bd5ad-c5be-4332-8edd-361c7c9d21cd/download https://www.repository.cam.ac.uk/bitstreams/f5e1b3bd-a2eb-44eb-a61c-9cb979448a68/download Genizah MS T-S AS 136.360 http://purl.org/coar/resource_type/c_1843 Unknown 2011-02-25 Taylor-Schechter Genizah Research Unit 2011-02-25

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Affirmative (iṯbāt) and negative expressions (nafy), quoting Genesis 27:22 http://www.dspace.cam.ac.uk/handle/1810/231034 jrb heb https://www.repository.cam.ac.uk/bitstreams/22dd54ef-cbc6-4166-97f9-484dd3ed1469/download https://www.repository.cam.ac.uk/bitstreams/379135b3-951d-4cbd-9fb5-1f88a7721c5a/download https://www.repository.cam.ac.uk/bitstreams/7f38c4c2-2a73-4b55-adcd-beedac153bc0/download https://www.repository.cam.ac.uk/bitstreams/8f180898-3209-48af-a5fb-9bfcf558c74f/download https://www.repository.cam.ac.uk/bitstreams/dd45d169-fbdb-4b6a-a92c-50c9834c8ea8/download https://www.repository.cam.ac.uk/bitstreams/f8841ad1-b917-4ebf-a36a-3b1443be7a57/download Genizah MS T-S AS 140.78 http://purl.org/coar/resource_type/c_1843 Unknown 2011-02-24 Taylor-Schechter Genizah Research Unit 2011-02-24

oai:www.repository.cam.ac.uk:1810/3968752026-02-07T05:30:30Zcom_1810_751com_1810_256067col_1810_294790

Characterizing dust attenuation is crucial for revealing the intrinsic physical properties of galaxies. We present an analysis of dust attenuation in 18 spectroscopically confirmed star-forming main-sequence galaxies at z = 4.4−5.7 observed with JWST/NIRSpec IFU and NIRCam, selected from the ALPINE and CRISTAL ALMA large programs. We fit the emission-line fluxes from NIRSpec and the broadband photometry from NIRCam with Prospector, using both spatially integrated emission and ∼0.6 kpc pixel-by-pixel measurements. We derive the stellar-to-nebular dust attenuation ratio (f = E(B − V)star/E(B − V)neb) from the SED fits and the Balmer decrement with Hα and Hβ. Although individual galaxies show large scatter, the best-fit value is f=0.51−0.03+0.04 , slightly higher than that measured for local starburst galaxies. We find weak correlations of f with galaxy properties, increasing with higher specific star formation rates, younger stellar ages, and more recent star formation. For the range of E(B − V)star = 0.009−0.15 mag for in our sample, assuming f = 1 (often adopted in high-redshift studies) instead of f = 0.51 leads to the underestimation of line luminosities and ionizing photon production efficiency ξion by ∼3%−36% and ∼4 %−46%, respectively. Finally, total stellar masses estimated from spatially integrated SED fits with delayed-τ star formation histories are systematically smaller than the sums of pixel-by-pixel SED fits by a median of ∼0.26 dex, likely because the integrated fits are biased toward luminous young stellar populations. https://www.repository.cam.ac.uk/handle/1810/396875 eng https://www.repository.cam.ac.uk/bitstreams/462a914e-28bd-4004-b29d-ef6967241484/download https://www.repository.cam.ac.uk/bitstreams/10572596-4f2d-4a1d-9a01-d2d69b417f47/download 0004-637X 5109 Space Sciences 51 Physical Sciences The ALPINE-CRISTAL-JWST Survey: Stellar and Nebular Dust Attenuation of Main-sequence Galaxies at z ∼ 4–6 http://purl.org/coar/resource_type/c_6501 2025-11-19 https://orcid.org/0000-0002-0498-5041 Tsujita, Akiyoshi https://orcid.org/0000-0001-7201-5066 Fujimoto, Seiji https://orcid.org/0000-0002-9382-9832 Faisst, Andreas https://orcid.org/0000-0003-0946-6176 Boquien, Médéric https://orcid.org/0000-0002-8184-5229 Li, Juno https://orcid.org/0000-0002-9400-7312 Ferrara, Andrea https://orcid.org/0000-0003-4569-2285 Battisti, Andrew J https://orcid.org/0009-0007-7842-9930 Dam, Poulomi https://orcid.org/0000-0002-6290-3198 Aravena, Manuel https://orcid.org/0000-0002-3915-2015 Béthermin, Matthieu https://orcid.org/0000-0002-0930-6466 Casey, Caitlin M https://orcid.org/0000-0003-3881-1397 Cooper, Olivia R https://orcid.org/0000-0001-8519-1130 Finkelstein, Steven L https://orcid.org/0000-0002-9122-1700 Ginolfi, Michele https://orcid.org/0009-0008-1835-7557 Gómez-Espinoza, Diego A https://orcid.org/0009-0003-3097-6733 Hadi, Ali https://orcid.org/0000-0002-2775-0595 Herrera-Camus, Rodrigo https://orcid.org/0009-0008-9801-2224 Ibar, Edo https://orcid.org/0000-0003-4268-0393 Inami, Hanae https://orcid.org/0000-0002-0267-9024 Jones, Gareth C https://orcid.org/0000-0002-6610-2048 Koekemoer, Anton M https://orcid.org/0000-0002-4052-2394 Kohno, Kotaro https://orcid.org/0000-0002-1428-7036 Lemaux, Brian C https://orcid.org/0000-0002-9252-114X Liu, Zhaoxuan https://orcid.org/0000-0001-9419-6355 De Looze, Ilse https://orcid.org/0000-0001-7300-9450 Mitsuhashi, Ikki https://orcid.org/0000-0001-5846-4404 Mobasher, Bahram https://orcid.org/0000-0002-8136-8127 Molina, Juan https://orcid.org/0000-0001-6652-1069 Nanni, Ambra https://orcid.org/0000-0002-7412-647X Pozzi, Francesca https://orcid.org/0000-0001-9687-4973 Reddy, Naveen A https://orcid.org/0000-0003-1682-1148 Relano, Monica https://orcid.org/0000-0002-9415-2296 Rodighiero, Giulia https://orcid.org/0000-0002-9948-3916 Romano, Michael https://orcid.org/0000-0002-1233-9998 Sanders, David B https://orcid.org/0000-0002-0498-8074 Sawant, Prasad https://orcid.org/0000-0001-6629-0379 Solimano, Manuel https://orcid.org/0000-0002-2906-2200 Sommovigo, Laura https://orcid.org/0000-0003-3256-5615 Spilker, Justin https://orcid.org/0000-0001-9728-8909 Tadaki, Ken-ichi https://orcid.org/0000-0002-3258-3672 Vallini, Livia https://orcid.org/0000-0002-5877-379X Villanueva, Vicente https://orcid.org/0000-0002-7964-6749 Wang, Wuji https://orcid.org/0000-0002-2318-301X Zamorani, Giovanni collaborations, ALPINE CRISTAL https://doi.org/10.3847/1538-4357/ae22d8 24KJ0562 FB210003 ANR-15- IDEX-01 MO2020/38/E/ST9/00077 UMO2020/38/E/ST9/00077 ASTRO21-0062 FB210003 NCN2024_112 1221846 ERC-2019- StG-851622 C4000142239 G0A1523N JP22H04939 JP23K20035 JP24H00004 2026-02-01 American Astronomical Society 2026-01-29

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Following previous editions, the fifteenth annual workshop of the European Network for Breast Development and Cancer (ENBDC) on Methods in Mammary Gland Biology and Breast Cancer was held from the 2nd to the 4th of May in Weggis, Switzerland. Over the course of this meeting, participants followed and discussed presentations from a roster of internationally renowned invited speakers and selected abstracts, complemented with two poster sessions covering exciting unpublished results. The sessions covered projects on normal mammary gland development, breast cancer evolution and metastasis, as well as epigenetic and metabolic regulation of breast cancer. As last year, early career researchers (ECR) hosted a pre-workshop day, when a stage was provided to allow PhD students and postdocs to showcase their projects and results, and when they had ample time for discussions on experimental settings and career planning, while interacting with several invited guests. https://www.repository.cam.ac.uk/handle/1810/376684 eng https://www.repository.cam.ac.uk/bitstreams/2f8edde2-2eb9-4e20-aca5-de0a78b24542/download https://www.repository.cam.ac.uk/bitstreams/4b0e48ee-fd4a-453a-a5ae-a6df88e42063/download 1083-3021 Breast cancer Lineage tracing Stem cell potency Mouse models Metastasis Mammary gland biology Therapy resistance Organoids 15th Annual ENBDC Meeting: How do Cellular Potency, Microenvironment and Natural Rhythms Influence Mammary Gland Biology and Breast Cancer? http://purl.org/coar/resource_type/c_1843 2024-11-05 Rafaeva, Maria Kaczyńska, Beata Redondo-Pedraza, Jaime Bentires-Alj, Mohamed Khaled, Walid T. Fre, Silvia https://doi.org/10.1007/s10911-024-09572-2 2024-11-25 Springer US 2024-11-25

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Letter http://www.dspace.cam.ac.uk/handle/1810/232082 jrb https://www.repository.cam.ac.uk/bitstreams/32389a7e-2277-4b0f-a1e3-97563df0c349/download https://www.repository.cam.ac.uk/bitstreams/4eca0132-09d5-4317-b077-b965cc88b059/download https://www.repository.cam.ac.uk/bitstreams/5d50796a-4fe6-4588-9015-7a7697ab08c1/download https://www.repository.cam.ac.uk/bitstreams/881f12d0-eb5d-40cd-8d96-c5854bef512f/download https://www.repository.cam.ac.uk/bitstreams/9113a403-4d37-424c-b990-3222ec7f4c2d/download https://www.repository.cam.ac.uk/bitstreams/f65974a7-dfd6-48d0-b9eb-ce670782c238/download Genizah MS T-S AS 146.263 http://purl.org/coar/resource_type/c_1843 Unknown 2011-02-24 Taylor-Schechter Genizah Research Unit 2011-02-24

oai:www.repository.cam.ac.uk:1810/2849272025-12-19T17:56:31Zcom_1810_229649com_1810_751com_1810_256067col_1810_368714

Gas bubbles form as magmas ascend in the crust and exsolve volatiles. These bubbles evolve chemically and physically as magma decompression and crystallization proceed. It is generally assumed that the gas remains in thermal equilibrium with the melt but the relationship between gas and melt redox state is debated. Here, using absorption spectroscopy, we report the composition of gases emitted from the lava lake of Kīlauea Volcano, Hawaii, and calculate equilibrium conditions for the gas emissions. Our observations span a transition between more and less vigorous-degassing regimes. They reveal a temperature range of up to 250 °C, and progressive oxidation of the gas, relative to solid rock buffers, with decreasing gas temperature. We suggest that these phenomena are the result of changing gas bubble size. We find that even for more viscous magmas, fast-rising bubbles can cool adiabatically, and lose the redox signature of their associated melts. This process can result in rapid changes in the abundances of redox-sensitive gas species. Gas composition is monitored at many volcanoes in support of hazard assessment but time averaging of observations can mask such variability arising from the dynamics of degassing. In addition, the observed redox decoupling between gas and melt calls for caution in using lava chemistry to infer the composition of associated volcanic gases. https://www.repository.cam.ac.uk/handle/1810/284927 eng https://doi.org/10.17863/CAM.32297 https://www.repository.cam.ac.uk/bitstreams/cf0add01-1d84-4d6b-af71-f7c48063e398/download 1752-0894 37 Earth Sciences 3703 Geochemistry 3705 Geology 3706 Geophysics Influence of eruptive style on volcanic gas emission chemistry and temperature http://purl.org/coar/resource_type/c_6501 2018-06-25 Oppenheimer, Clive Scaillet, Bruno Woods, Andrew Sutton, A Jeff Elias, Tamar Moussallam, Yves https://doi.org/10.1038/s41561-018-0194-5 GA/13M/031 NE/N009312/1 2018-09 Springer Nature 2018-11-12

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CAG repeat expansion in the HTT gene drives Huntington's disease (HD) pathogenesis and is modulated by DNA damage repair pathways. In this context, the interaction between FAN1, a DNA-structure-specific nuclease, and MLH1, member of the DNA mismatch repair pathway (MMR), is not defined. Here, we identify a highly conserved SPYF motif at the N terminus of FAN1 that binds to MLH1. Our data support a model where FAN1 has two distinct functions to stabilize CAG repeats. On one hand, it binds MLH1 to restrict its recruitment by MSH3, thus inhibiting the assembly of a functional MMR complex that would otherwise promote CAG repeat expansion. On the other hand, it promotes accurate repair via its nuclease activity. These data highlight a potential avenue for HD therapeutics in attenuating somatic expansion. https://www.repository.cam.ac.uk/handle/1810/330058 eng https://doi.org/10.17863/CAM.77502 https://www.repository.cam.ac.uk/bitstreams/e4591fc1-4b80-49a7-ac6a-1af1b84bc1eb/download 2639-1856 CAG instability DNA repair FAN1 FAN1 nuclease activity GWAS Huntington’s disease MLH1 MSH3 mismatch repair repeat expansion Animals Binding, Competitive Brain Cell Line, Tumor DNA Damage DNA Mismatch Repair Endodeoxyribonucleases Exodeoxyribonucleases HEK293 Cells Humans Huntingtin Protein Huntington Disease Mice Multifunctional Enzymes MutL Protein Homolog 1 MutS Homolog 3 Protein Protein Binding Protein Interaction Domains and Motifs Trinucleotide Repeat Expansion FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease. http://purl.org/coar/resource_type/c_6501 2021-08-11 Goold, Robert Hamilton, Joseph Menneteau, Thomas Flower, Michael Bunting, Emma L Aldous, Sarah G Porro, Antonio Vicente, José R Allen, Nicholas D Wilkinson, Hilary Bates, Gillian P Sartori, Alessandro A Thalassinos, Konstantinos https://orcid.org/0000-0003-2872-4468 Balmus, Gabriel Tabrizi, Sarah J https://doi.org/10.1016/j.celrep.2021.109649 MR/L023784/2 200181/Z/15/Z 2021-08-31 Elsevier 2021-10-29

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In this thesis, we deal with the application of transmission terahertz spectroscopy as an analysis tool for the study of molecular solids, in particular organic crystals of pharmaceutical interest. Most of the work has been performed using two computational packages aimed at the interpretation of the spectra, one based on molecular forcefields (DMACRYS), the other on solid state density functional theory (CASTEP). We compare low temperature determinations of several molecular organic crystals to calculated spectra, and attempt to assign calculated modes of vibrations to absorption peaks, based on the similarity in frequency between the measured and calculated peaks. One of the main aims of this work is to establish the limits of our forcefield approach, which is based on the approximation that the intramolecular degrees of freedom can be neglected. We analyse the normal modes of vibration calculated with CASTEP, evaluating the amount of rigid molecule rotational and translational contribution to each eigenvector as a function of frequency, in order to validate our forcefield approach. We also compare the two sets of eigenvectors from the DMACRYS and CASTEP calculations to assess the similarity between the two approaches. We perform the same eigenvectors analysis on several hydrate systems in order to understand the role of water in the lattice dynamics of crystalline hydrates. We attempt a classification of the eigenvectors based on the strength of the forces involved in the molecular vibrations and based on the amount of the water contribution to each normal mode. A set of isostructural crystals is analysed in order to understand the effect that small variations (in the molecular formula and in the unit cell arrangement) have on the measured and calculated absorption spectra of a crystal. Finally, we discuss the use and development of computational methods that allow us to have a more realistic description of the molecular electrostatic in DMACRYS. http://www.dspace.cam.ac.uk/handle/1810/243650 https://www.repository.cam.ac.uk/handle/1810/243650 eng https://doi.org/10.17863/CAM.16291 https://www.repository.cam.ac.uk/bitstreams/60151c98-8b8c-46bf-8df6-6663c3375a6f/download Terahertz Spectroscopy Organic Materials Simulation DFT DMACRYS CASTEP A computational analysis of the vibrational absorption of molecular solids in the teraherz range http://purl.org/coar/resource_type/c_46ec Day, Graeme M. Tomerini, Daniele 2012-07-03 2012-08-22

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https://www.repository.cam.ac.uk/handle/1810/314380 eng https://doi.org/10.17863/CAM.61483 https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/aa562686-7871-41d4-b8a8-bb264c77a0fe/download Deed Lamin clan Ivan Modunkaev, About the Deed Lamin clan http://purl.org/coar/resource_type/c_12ce Terbish, Baasanjav Churyumova, Elvira Seleeva, Tsagan Terbish, Baasanjav 2014-12-01 Kalmyk Cultural Heritage Documentation Project, University of Cambridge 2020-12-03

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AIM: Evidence from mouse models suggests that brain serotonergic pathways control blood glucose. We hypothesized that sumatriptan (5HT1B -receptor agonist) would alter glucose homeostasis in humans. MATERIALS AND METHODS: We conducted a two-visit random-order double-blinded placebo-controlled cross-over trial in 10 overweight adults that were otherwise healthy. Participants received sumatriptan (single dose, 100 mg) or placebo before undergoing a 60-min intravenous glucose tolerance test, followed by a 120-min hyperinsulinaemic euglycaemic clamp. RESULTS: Glucose excursion was greater during intravenous glucose tolerance test with sumatriptan compared with placebo [iAUC0-60 min 316 (268-333) vs. 251 (197-319) min/mmol/L p = .047]. This was probably explained by a combination of reduced circulating insulin levels [iAUC0-10 min 1626 (1103-2733) vs. 2336 (1702-3269) min/pmol/L, p = .005], reduced insulin sensitivity [M/I-value 2.11 (1.15, 4.05) vs. 3.03 (1.14, 4.90) mg/kg/min per pmol/L, p = .010] and glucose effectiveness [SG 0.17 (0.12, 0.21) vs. 0.22 (0.18, 0.65)/min, p = .027]. CONCLUSIONS: 5HT1B receptors have a glucoregulatory role in humans, probably acting on insulin secretion, insulin sensitivity and glucose effectiveness. https://www.repository.cam.ac.uk/handle/1810/352673 eng https://www.repository.cam.ac.uk/bitstreams/1b4bd55f-7cf9-4d63-9ce5-b29dd759bbae/download https://www.repository.cam.ac.uk/bitstreams/4a95d931-eaa6-43d9-8d50-b563a3d52340/download 1462-8902 beta cell function drug mechanism effectiveness glycaemic control insulin secretion randomised trial Adult Animals Mice Humans Glucose Overweight Insulin Secretion Insulin Resistance Sumatriptan Serotonin Cross-Over Studies Insulin Blood Glucose Double-Blind Method Sumatriptan, a serotonin 5HT1B receptor agonist, acutely reduces insulin secretion and sensitivity and glucose effectiveness in overweight humans: A double-blinded placebo-controlled cross-over trial. http://purl.org/coar/resource_type/c_1843 2023-05-29 https://orcid.org/0000-0003-0419-9582 Golubic, Rajna Hussein Ismail, Mouhamad Josipovic, Masa Kennet, Jane Galderisi, Alfonso https://orcid.org/0000-0001-8122-8987 Evans, Mark L https://doi.org/10.1111/dom.15176 2023-10 Wiley 2023-06-22

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The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder. https://www.repository.cam.ac.uk/handle/1810/332439 eng https://doi.org/10.17863/CAM.79885 https://www.repository.cam.ac.uk/bitstreams/8b891fca-a7d8-4daa-9351-5b87a166e3f0/download 2076-3425 PGS bipolar disorder cognition hazardous drinking reaction time schizoaffective disorder schizophrenia visual memory Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder. http://purl.org/coar/resource_type/c_6501 2021-10-26 https://orcid.org/0000-0002-2148-4070 Mazumder, Atiqul Haq Barnett, Jennifer https://orcid.org/0000-0001-5956-2399 Isometsä, Erkki Tapio Lindberg, Nina https://orcid.org/0000-0003-2149-855X Torniainen-Holm, Minna https://orcid.org/0000-0002-7244-145X Lähteenvuo, Markku Lahdensuo, Kaisla https://orcid.org/0000-0002-1181-2632 Kerkelä, Martta https://orcid.org/0000-0002-4451-3487 Ahola-Olli, Ari https://orcid.org/0000-0002-3179-6780 Hietala, Jarmo https://orcid.org/0000-0001-6891-2266 Kampman, Olli Kieseppä, Tuula Jukuri, Tuomas https://orcid.org/0000-0001-8222-7505 Häkkinen, Katja Cederlöf, Erik https://orcid.org/0000-0002-2850-7650 Haaki, Willehard https://orcid.org/0000-0002-3405-7115 Kajanne, Risto Wegelius, Asko Männynsalo, Teemu Niemi-Pynttäri, Jussi https://orcid.org/0000-0001-6296-6343 Suokas, Kimmo Lönnqvist, Jouko https://orcid.org/0000-0002-0400-6798 Tiihonen, Jari https://orcid.org/0000-0002-5560-0666 Paunio, Tiina https://orcid.org/0000-0001-9319-3566 Vainio, Seppo Juhani https://orcid.org/0000-0002-2527-5874 Palotie, Aarno https://orcid.org/0000-0003-1130-9161 Niemelä, Solja https://orcid.org/0000-0001-7167-0990 Suvisaari, Jaana https://orcid.org/0000-0002-4139-9981 Veijola, Juha https://doi.org/10.3390/brainsci11111422 0400 584622 6045290-5500000710 and 6000009-5500000710 713606 2021-10-27 MDPI 2022-01-07

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An archaeological excavation was undertaken in May 2007 on 0.0036 ha of land on the south-eastern side of Chairfen Road, at Green Farm, Thistley Green, West Row, Suffolk (TL 6613 7614). The site was located within a chalk landscape at 3.001m to 3.187m OD, in an area of known prehistoric activity. However, no archaeological features were recorded in the machine excavated 6m by 6m area, which was situated on ploughed ground. https://www.repository.cam.ac.uk/handle/1810/356143 eng https://doi.org/10.17863/CAM.100817 https://www.repository.cam.ac.uk/bitstreams/daf2cb53-d844-43e1-ad60-40df416fbb4e/download Land at Thistley Green, West Row, Suffolk. An Archaeological Evaluation http://purl.org/coar/resource_type/c_93fc Murrell, Kerry 2007-05-06 Cambridge Archaeological Unit, Department of Archaeology, University of Cambridge 2023-09-05

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INTRODUCTION: Higher male prevalence in sporadic behavioral variant frontotemporal dementia (bvFTD) has been reported. We hypothesized differences in phenotypes between genetic and sporadic bvFTD females resulting in underdiagnosis of sporadic bvFTD females. METHODS: We included genetic and sporadic bvFTD patients from two multicenter cohorts. We compared behavioral and cognitive symptoms, and gray matter volumes, between genetic and sporadic cases in each sex. RESULTS: Females with sporadic bvFTD showed worse compulsive behavior (p = 0.026) and language impairments (p = 0.024) compared to females with genetic bvFTD (n = 152). Genetic bvFTD females had smaller gray matter volumes than sporadic bvFTD females, particularly in the parietal lobe. DISCUSSION: Females with sporadic bvFTD exhibit a distinct clinical phenotype compared to females with genetic bvFTD. This difference may explain the discrepancy in prevalence between genetic and sporadic cases, as some females without genetic mutations may be misdiagnosed due to atypical bvFTD symptom presentation. HIGHLIGHTS: Sex ratio is equal in genetic behavioral variant of frontotemporal dementia (bvFTD), whereas more males are present in sporadic bvFTD. Distinct neuropsychiatric phenotypes exist between sporadic and genetic bvFTD in females. Phenotype might explain the sex ratio difference between sporadic and genetic cases. https://www.repository.cam.ac.uk/handle/1810/383365 eng https://www.repository.cam.ac.uk/bitstreams/1ecf3ad3-986a-40b2-a741-a72c5e06e41e/download https://www.repository.cam.ac.uk/bitstreams/c47178cf-62d6-423a-9fa6-42b0a3228130/download 1552-5260 behavioral variant frontotemporal dementia clinical diagnosis diversity sex difference Aged Female Humans Male Middle Aged Brain Cohort Studies Frontotemporal Dementia Gray Matter Magnetic Resonance Imaging Neuropsychological Tests Phenotype Sex Characteristics Sex Factors Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia. http://purl.org/coar/resource_type/c_6501 2025-01-17 Liu, Xulin de Boer, Sterre CM Cortez, Kasey Poos, Jackie M Illán-Gala, Ignacio Heuer, Hilary Forsberg, Leah K Casaletto, Kaitlin Memel, Molly Appleby, Brian S Barmada, Sami Bozoki, Andrea Clark, David Cobigo, Yann Darby, Ryan Dickerson, Bradford C Domoto-Reilly, Kimiko Galasko, Douglas R Geschwind, Daniel H Ghoshal, Nupur Graff-Radford, Neill R Grant, Ian M Hsiung, Ging-Yuek Robin Honig, Lawrence S Huey, Edward D Irwin, David Kantarci, Kejal Léger, Gabriel C Litvan, Irene Mackenzie, Ian R Masdeu, Joseph C Mendez, Mario F Onyike, Chiadi U Pascual, Belen Pressman, Peter Bayram, Ece Ramos, Eliana Marisa Roberson, Erik D Rogalski, Emily Bouzigues, Arabella Russell, Lucy L Foster, Phoebe H Ferry-Bolder, Eve Masellis, Mario van Swieten, John Jiskoot, Lize Seelaar, Harro Sanchez-Valle, Raquel Laforce, Robert Graff, Caroline Galimberti, Daniela Vandenberghe, Rik de Mendonça, Alexandre Tiraboschi, Pietro Santana, Isabel Gerhard, Alexander Levin, Johannes Sorbi, Sandro Otto, Markus Pasquier, Florence Ducharme, Simon Butler, Chris R Ber, Isabelle Le Finger, Elizabeth Rowe, James B Synofzik, Matthis Moreno, Fermin Borroni, Barbara Boeve, Brad F Boxer, Adam L Rosen, Howie J Pijnenburg, Yolande AL Rohrer, Jonathan D Tartaglia, Maria Carmela ALLFTD Consortium and the GENFI Consortium https://doi.org/10.1002/alz.14608 103838/Z/14/Z 220258/Z/20/Z MR/T033371/1 IS-BRC-1215-20014 MC_UU_00030/14 2025-04 Wiley 2025-04-25

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Abstract: Any given cell type has an associated “normal” nuclear morphology, which is im-portant to maintain proper cellular functioning and safeguard genomic integrity. Deviations from this can be indicative of diseases such as cancer or premature aging syndrome. To accurately as-sess nuclear abnormalities, it is important to use quantitative measures of nuclear morphology. Here, we give an overview of several nuclear abnormalities including micronuclei, nuclear enve-lope invaginations, blebs and ruptures and review the current methods used for image-based quantification of these abnormalities. We discuss several parameters that can be used to quantify nuclear shape and compare their outputs using example images. In addition, we present new pipelines for quantitative analysis of nuclear blebs and invaginations. Quantitative analysis of nuclear aberrations and shape will be important in a wide range of applications, from assessment of cancer cells anomalies to studies of nucleus deformability under mechanical or other types of stress. https://www.repository.cam.ac.uk/handle/1810/332799 eng https://doi.org/10.17863/CAM.80232 https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/55c4d2a4-4fcd-4692-84c0-20e0ce8bafec/download 2073-4409 Current methods and pipelines for image-based quantitation of nuclear shape and nuclear envelope abnormalities http://purl.org/coar/resource_type/c_6501 2022-01-18 https://orcid.org/0000-0002-2335-9361 Larrieu, Delphine Janssen, Anne Breusegem, Sophia https://doi.org/10.3390/cells11030347 206242/Z/17/Z Anne Janssen FEBS LTF 2022-01-20 MDPI AG 2022-01-20

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BACKGROUND: The 'optimal' CPP (CPPopt) concept is based on the vascular pressure reactivity index (PRx). The feasibility and effectiveness of CPPopt guided therapy in severe traumatic brain injury (TBI) patients is currently being investigated prospectively in the COGiTATE trial. At the moment there is no clear evidence that certain admission and treatment characteristics are associated with CPPopt availability (yield). OBJECTIVE: To test the relation between patients' admission and treatment characteristics and the average CPPopt yield. METHODS: Retrospective analysis of 230 patients from the CENTER-TBI high-resolution database with intracranial pressure (ICP) measured using an intraparenchymal probe. CPPopt was calculated using the algorithm set for the COGiTATE study. CPPopt yield was defined as the percentage of CPP monitored time (%) when CPPopt is available. The variables in the statistical model included age, admission Glasgow Coma Scale (GCS), gender, pupil response, hypoxia and hypotension at the scene, Marshall computed tomography (CT) score, decompressive craniectomy, injury severity score score and 24-h therapeutic intensity level (TIL) score. RESULTS: The median CPPopt yield was 80.7% (interquartile range 70.9-87.4%). None of the selected variables showed a significant statistical correlation with the CPPopt yield. CONCLUSION: In this retrospective multicenter study, none of the selected admission and treatment variables were related to the CPPopt yield. https://www.repository.cam.ac.uk/handle/1810/304474 eng https://doi.org/10.17863/CAM.51553 https://www.repository.cam.ac.uk/bitstreams/b8d23e72-51f5-4455-ba8b-305091d39e99/download 0065-1419 Cerebral autoregulation ICP monitoring Optimal CPP TBI Brain Injuries, Traumatic Cerebrovascular Circulation Glasgow Coma Scale Humans Intracranial Pressure Retrospective Studies Patient's Clinical Presentation and CPPopt Availability: Any Association? http://purl.org/coar/resource_type/c_6501 2020-04-14 Liberti, Annalisa Beqiri, Erta https://orcid.org/0000-0001-8350-8093 Ercole, Ari Cabeleira, Manuel Tas, Jeanette Zeiler, Frederick A Czosnyka, Marek https://orcid.org/0000-0001-5096-3938 Smielewski, Peter Aries, Marcel J CENTER-TBI High Resolution Substudy Participants and Investigators https://doi.org/10.1007/978-3-030-59436-7_34 602150 2021 Springer Nature 2020-04-17

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If the physical properties of a structural component are sufficiently random then the statistical distribution of the natural frequencies and mode shapes tends to a universal distribution associated with the Gaussian Orthogonal Ensemble (GOE) of random matrices. Previous work has exploited this result to yield expressions for the relative variance of the energy of the response of a random system to harmonic excitation. The derivation of these expressions employed random point process theory, and in the theoretical development it was assumed that the modal generalised forces were uncorrelated. Although this assumption is often valid, there are cases in which correlations between the generalised forces can significantly affect the response variance, and in the present work the existing theory is extended to include correlations of this type. The extended theory is applicable to both single frequency responses and to band average responses, and the developed closed form expressions are validated by comparison with direct simulations for a random plate structure. https://www.repository.cam.ac.uk/handle/1810/270068 eng https://doi.org/10.17863/CAM.12490 https://www.repository.cam.ac.uk/bitstreams/6f7faad0-141c-41f7-a4fb-4f69fe36bce3/download 0022-460X 4006 Communications Engineering 40 Engineering The effect of generalized force correlations on the response statistics of a harmonically driven random system http://purl.org/coar/resource_type/c_6501 2017-08-09 Langley, RS Cicirello, A Deckers, E https://doi.org/10.1016/j.jsv.2017.08.011 2018-01-20 Elsevier 2017-12-07

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https://www.repository.cam.ac.uk/handle/1810/314390 ru https://doi.org/10.17863/CAM.61494 https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/1a0c70fc-53a6-4b1f-af5c-06b4d55c197f/download Parents Sergei Olzeev, About my parents http://purl.org/coar/resource_type/c_12ce Churyumova, Elvira Korneev, Gennadiy Sandzhiev, Artur Churyumov, Anton Terbish, Baasanjav 2018-03-01 Kalmyk Cultural Heritage Documentation Project, University of Cambridge 2020-12-03

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Beginning of an 11th c. business letter sent to Abū Yaḥyā Nahrāy b. Nissim. Mentions Rašīd. http://www.dspace.cam.ac.uk/handle/1810/235549 jrb ara https://www.repository.cam.ac.uk/bitstreams/31200a8a-8191-45d8-9379-88875a6953ab/download https://www.repository.cam.ac.uk/bitstreams/41643f83-224f-4ecf-8512-404f9e7ff41c/download https://www.repository.cam.ac.uk/bitstreams/489b2c89-2424-4e50-97f8-9dc90f3eb381/download https://www.repository.cam.ac.uk/bitstreams/5c1eaa4f-1221-47c0-affc-88869a3ce587/download https://www.repository.cam.ac.uk/bitstreams/63f2e4b5-3919-43f2-9aa0-144d2ade885f/download https://www.repository.cam.ac.uk/bitstreams/8afadca4-34c0-4a32-b39a-de7b51f63fff/download Genizah MS T-S AS 152.148 http://purl.org/coar/resource_type/c_1843 Unknown 2011-02-25 Taylor-Schechter Genizah Research Unit 2011-02-25

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This article explores three utopian visions which have shaped past and present experiences within Buenos Aires shantytowns: those of upgraded shantytowns, of universal housing, and of a city where shantytowns have been eliminated. The article argues that these visions are collective conceptions that entail a socio‐political critique which is translated into space and which points to an ideal future. The visions proposed emerge from the examination of historical evidence and are a key conceptual tool for understanding previous and current discussions of shantytowns in Latin America. https://www.repository.cam.ac.uk/handle/1810/257314 eng https://doi.org/10.17863/CAM.1246 https://www.repository.cam.ac.uk/bitstreams/02eee95d-967a-4f7e-b28b-d582ada08f0f/download 0261-3050 4406 Human Geography 44 Human Society Utopian Visions for Buenos Aires Shantytowns: Collective Imaginaries of Housing Rights, Upgrading and Eviction (1956–2013) http://purl.org/coar/resource_type/c_6501 2016-07-05 MASSIDDA, ADRIANA L https://doi.org/10.1111/blar.12559 2018-04 Wiley 2016-08-17

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The forthcoming chapters delve into monetary and international economics, with a particular focus on the role of uncertainty and risk in driving the strategies of economic agents. They explore the interplay between individual behaviors and macroeconomic trends by leveraging micro data to answer macroeconomic questions. The first chapter explores the drivers of inflation inequality across households. In particular, it examines how households use heterogeneously the quality margin of the varieties they purchase to insure themselves against shocks. Using household scanner data of supermarket consumption for Germany, I analyse the extent to which households trade down in the quality of goods in the aftermath of a recession. First, I document that, on average, lower income households tend to purchase lower quality goods. Furthermore, lower income households exhibit a low propensity to trade down, presumably due to a limited capacity to do so. This is in contrast with the rest of households, who appear to trade further down in the quality of goods. This is suggestive evidence of a lower bound in the quality margin available for certain households. Next, I analyse the aggregate effects of this phenomenon on product-level inflation, namely, the effect of an aggregate demand shift towards lower quality varieties in the beginning of a recession. For it, I employ a shift-share research design based on population growth of narrowly defined groups of households to predict the amount of trading down when the recession hits, therefore identifying a reasonably exogenous demand shifter. The intuition is that in the regions where the household groups that are more likely to trade down in the quality of goods grow faster, the amount of trading down once the recession starts will be larger. I find that a generalised demand shift toward lower quality goods during recessions leads to an increased price of low quality varieties compared to the price of higher quality varieties. In particular, on average, a 1% increase in the demand for lower quality varieties due to households trading down in the quality of the varieties they purchase translates into a 0.33% increase in the relative price of low compared higher quality varieties. The second chapter, co-authored with Giancarlo Corsetti and Luca Dedola, investigates whether and how heterogeneity in consumption risk and inflation across households affect consumption demand and growth under the lens of an incomplete markets framework. Our model of household-level risk sharing imposes minimal restrictions on the financial market structure, allowing for both aggregate and idiosyncratic tradeable risks to be at least partially diversified, and for precautionary saving motives. We bring the model to bear on empirical evidence, using household-level scanner data from Euro area regions and United Kingdom, together with a matching model for financial market participation. Our contribution is twofold: first, we develop a theoretical framework mapping consumption (rather than income) risk and inflation differentials onto consumption growth at regional level; second, we assess theoretical conditions empirically, exploiting heterogeneity in risk and risk sharing, by preference, income, residence and participation in financial markets. Our empirical analysis provides evidence that tradeable risk is insured primarily among financial market participants, and across regions of the euro area than regions across the border (provided that differences in inflation are accounted for). Consumption risk, proxied using variability of consumption growth within regions and income groups, weigh on consumption demand. The third chapter, co-authored with Meredith Crowley, Elisa Faraglia and Chryssi Giannitsarou, explores how British firms adapted to the uncertain commercial environment through establishing new EU subsidiaries and operations. In particular, we first study the intertemporal variation in the number of newly-established subsidiaries of British firms in the EU from 2016 to 2021. We find that, in the post-referendum period, more subsidiaries were established by British parents in months and sectors in which the uncertainty over the future commercial relationship between the UK and EU was higher. This evidence suggests that subsidiaries were established to help firms hedge the risk of losing their access to the EU market. Finally, we use annual balance sheet data to examine the characteristics of British parent firms establishing their first subsidiary in the EU before and after the Brexit referendum. We conduct a difference-in-differences analysis in which we compare the characteristics of British parent firms establishing a first subsidiary in the EU to those of EU parent firms establishing a first subsidiary in another EU country before and after the referendum. We find that, in the year in which British parent firms established a first subsidiary in the EU and the year before that, the growth of turnover, profits, assets and cash flow was substantially lower for those firms establishing their first subsidiary between 2016 and 2022 relative to between 2012 and 2015 and relative to the change in growth for EU parent firms between these two periods. https://www.repository.cam.ac.uk/handle/1810/373563 eng https://doi.org/10.17863/CAM.111924 https://www.repository.cam.ac.uk/bitstreams/540d82e3-eeb8-4054-bf74-d9d08b0c79ff/download consumption inequality Heterogeneity inequality inflation inequality instrumental variables micro data policy uncertainty risk sharing scanner data shift-share research design trading down uncertainty Essays in International and Monetary Economics http://purl.org/coar/resource_type/c_46ec Domenech Palacios, Maria Del Mar 2024-09-24 2024-09-24

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Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal. We identified from the literature 56 single nucleotide polymorphisms (SNPs) in the IGF axis previously associated with biomarker levels (8 from a genome-wide association study [GWAS] and 48 in reported candidate genes). In ∼700 men without prostate cancer and two replication cohorts (N ∼ 900 and ∼9,000), we examined the properties of these SNPS as instrumental variables (IVs) for IGF-I, IGF-II, IGFBP-2 and IGFBP-3. Those confirmed as strong IVs were tested for association with prostate cancer risk, low (< 7) vs. high (≥ 7) Gleason grade, localised vs. advanced stage, and mortality, in 22,936 controls and 22,992 cases. IV analysis was used in an attempt to estimate the causal effect of circulating IGF peptides on prostate cancer. Published SNPs in the IGFBP1/IGFBP3 gene region, particularly rs11977526, were strong instruments for IGF-II and IGFBP-3, less so for IGF-I. Rs11977526 was associated with high (vs. low) Gleason grade (OR per IGF-II/IGFBP-3 level-raising allele 1.05; 95% CI: 1.00, 1.10). Using rs11977526 as an IV we estimated the causal effect of a one SD increase in IGF-II (∼265 ng/mL) on risk of high vs. low grade disease as 1.14 (95% CI: 1.00, 1.31). Because of the potential for pleiotropy of the genetic instruments, these findings can only causally implicate the IGF pathway in general, not any one specific biomarker. https://www.repository.cam.ac.uk/handle/1810/256029 eng https://www.repository.cam.ac.uk/bitstreams/22054b5f-a753-4245-b65d-29be01e252d3/download https://www.repository.cam.ac.uk/bitstreams/1360188f-cadc-4100-a05d-a066c0da51a0/download 0020-7136 ALSPAC IGFBP3 Mendelian randomization PRACTICAL ProtecT UKHLS insulin-like growth factor-binding proteins insulin-like growth factors prostate cancer single nucleotide polymorphisms Aged Case-Control Studies Genome-Wide Association Study Humans Insulin-Like Growth Factor Binding Proteins Longitudinal Studies Male Mendelian Randomization Analysis Middle Aged Neoplasm Grading Neoplasm Staging Polymorphism, Single Nucleotide Prostatic Neoplasms Somatomedins United Kingdom Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels. http://purl.org/coar/resource_type/c_6501 2016-04-07 Bonilla, Carolina Lewis, Sarah J Rowlands, Mari-Anne Gaunt, Tom R Davey Smith, George Gunnell, David Palmer, Tom Donovan, Jenny L Hamdy, Freddie C Neal, David E Eeles, Rosalind Easton, Doug Kote-Jarai, Zsofia Al Olama, Ali Amin Benlloch, Sara Muir, Kenneth Giles, Graham G Wiklund, Fredrik Grönberg, Henrik Haiman, Christopher A Schleutker, Johanna Nordestgaard, Børge G Travis, Ruth C Pashayan, Nora https://orcid.org/0000-0002-8802-2903 Khaw, Kay-Tee Stanford, Janet L Blot, William J Thibodeau, Stephen Maier, Christiane Kibel, Adam S Cybulski, Cezary Cannon-Albright, Lisa Brenner, Hermann Park, Jong Kaneva, Radka Batra, Jyotsna Teixeira, Manuel R Pandha, Hardev PRACTICAL consortium Lathrop, Mark Martin, Richard M Holly, Jeff MP https://doi.org/10.1002/ijc.30206 MR/N003284/1 G0401527 R01CA128978 G0500966 HTA no. 96/20/99 10710 12014 10118 U19CA148537 U19CA148065 G0401527/1 16565 2016-10-01 Wiley 2016-05-17

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Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes. https://www.repository.cam.ac.uk/handle/1810/311085 eng https://doi.org/10.17863/CAM.58174 https://www.repository.cam.ac.uk/bitstreams/0d456353-ae85-412e-a7be-5c1e723de5b4/download 2041-1723 Blood Vessels Cell Adhesion Humans Leukemia, Myeloid, Acute Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia. http://purl.org/coar/resource_type/c_6501 2020-07-09 https://orcid.org/0000-0002-0886-4466 Haltalli, Myriam LR https://orcid.org/0000-0002-1163-4207 Lo Celso, Cristina https://doi.org/10.1038/s41467-020-17594-7 2020-07-23 Springer Nature 2020-10-05

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ABSTRACT This article considers the relationship between belief and learning science. It is argued that belief in science (as a process) needs to be distinguished from belief in particular scienti c ideas and knowledge claims. Scienti c knowledge is theoretical and provisional – something to be adopted for its utility, not as articles of faith. The scienti c attitude is to always be sceptical and retain a critical attitude to what we think we know. Belief in scienti c knowledge is not only inappropriate in terms of scienti c values, but can also be unhelpful from an educational perspective. The science teacher should actually encourage students not to believe in the various theories, models and other products of scienti c work presented in class. This approach can avoid con icts with students’ personal beliefs, support scienti c literacy, and better prepare future scientists. https://www.repository.cam.ac.uk/handle/1810/277253 eng https://doi.org/10.17863/CAM.17825 https://www.repository.cam.ac.uk/bitstreams/64f4bed3-0457-4e2b-a287-2cd7bd049abc/download Things you should not believe in science http://purl.org/coar/resource_type/c_6501 2017-11-29 Taber, KS 2017-12-01 Association for Science Education 2018-06-19

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BACKGROUND AND OBJECTIVES: The use of over-the-counter laxatives is common in the general population. The microbiome-gut-brain axis hypothesis suggests that the use of laxatives could be associated with dementia. We aimed to examine the association between the regular use of laxatives and the incidence of dementia in UK Biobank participants. METHODS: This prospective cohort study was based on UK Biobank participants aged 40-69 years without a history of dementia. Regular use of laxatives was defined as self-reported use in most days of the week for the last 4 weeks at baseline (2006-2010). The outcomes were all-cause dementia, Alzheimer disease (AD), and vascular dementia (VD), identified from linked hospital admissions or death registers (up to 2019). Sociodemographic characteristics, lifestyle factors, medical conditions, family history, and regular medication use were adjusted for in the multivariable Cox regression analyses. RESULTS: Among the 502,229 participants with a mean age of 56.5 (SD 8.1) years at baseline, 273,251 (54.4%) were female, and 18,235 (3.6%) reported regular use of laxatives. Over a mean follow-up of 9.8 years, 218 (1.3%) participants with regular use of laxatives and 1,969 (0.4%) with no regular use developed all-cause dementia. Multivariable analyses showed that regular use of laxatives was associated with increased risk of all-cause dementia (hazard ratio [HR] 1.51; 95% CI 1.30-1.75) and VD (HR 1.65; 95% CI 1.21-2.27), with no significant association observed for AD (HR 1.05; 95% CI 0.79-1.40). The risk of both all-cause dementia and VD increased with the number of regularly used laxative types (p trend 0.001 and 0.04, respectively). Among the participants who clearly reported that they were using just 1 type of laxative (n = 5,800), only those using osmotic laxatives showed a statistically significantly higher risk of all-cause dementia (HR 1.64; 95% CI 1.20-2.24) and VD (HR 1.97; 95% CI 1.04-3.75). These results remained robust in various subgroup and sensitivity analyses. DISCUSSION: Regular use of laxatives was associated with a higher risk of all-cause dementia, particularly in those who used multiple laxative types or osmotic laxative. https://www.repository.cam.ac.uk/handle/1810/369665 eng https://www.repository.cam.ac.uk/bitstreams/b102bded-579a-46d1-9418-80432e8946f6/download 0028-3878 Humans Female Middle Aged Male Laxatives Constipation Prospective Studies Biological Specimen Banks Alzheimer Disease Dementia, Vascular United Kingdom Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants. http://purl.org/coar/resource_type/c_6501 2023-01-06 Yang, Zhirong Wei, Chang Li, Xiaojuan Yuan, Jinqiu Gao, Xuefeng Li, Bingyu Zhao, Ziyi Toh, Sengwee Yu, Xin https://orcid.org/0000-0001-5307-663X Brayne, Carol Yang, Zuyao Sha, Feng Tang, Jinling https://doi.org/10.1212/WNL.0000000000207081 2023-04-18 Wolters Kluwer 2024-06-18

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http://www.dspace.cam.ac.uk/handle/1810/195912 eng https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/99959745-8eb4-407d-bfe9-1550668a6cdc/download https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/100e3681-421f-422e-8d3b-e3af7eb40190/download https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/3c22be43-434a-40ac-8ee8-d76a5df93d32/download https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/6d863933-a0ba-4a12-a3d7-6153261ebaf2/download Queens' College, MS 83, 33r http://purl.org/coar/resource_type/c_c513 Burlinson, Christopher 2008-04-08 University of Cambridge, Faculty of English, Scriptorium: Medieval and Early Modern Manuscripts Online 2008-04-08

oai:www.repository.cam.ac.uk:1810/2943062025-12-19T17:56:59Zcom_1810_198332com_1810_256064col_1810_214775

Today, two-dimensional nanoscale magnetic systems are well understood, being used in applications from spintronic circuits to automotive sensing. Despite the great progress achieved in the field during the last decades, the development of three-dimensional devices is still hindered by phenomenal patterning and characterization challenges. Most lithographic and probing techniques have historically targeted planar samples and are not suitable for three dimensional geometries. This thesis achieves three key points to overcome these fabrication and characterization challenges: improving the understanding and control of 3D nano-printing of cobalt nanostructures using Focused Electron Beam Induced Deposition (FEBID), improving the performance of synchrotron-based magnetic X-ray microscopy in 3D geometries and adapting existing magneto-optical techniques to rapidly probe 3D nanostructures in the lab. As a result of this work, new tools and skills are available in the field of 3D nano-magnetism, unlocking a path for the development of sophisticated 3D nanomagnetic devices with increased functionality and performance. https://www.repository.cam.ac.uk/handle/1810/294306 eng https://doi.org/10.17863/CAM.41404 https://www.repository.cam.ac.uk/bitstreams/6e235828-b3f6-4933-9b5e-cf3cff492822/download 3D Three-Dimensional Magnetic MOKE Magneto Optical Kerr Effect Dark-Field Spintronics Micromagnetism Focused Electron Beam Induced Deposition FEBID Dicobalt Octacarbonyl Co2(CO)8 nanoprinting nanofabrication XMCD X-ray microscopy Hexapole Domain wall Racetrack memory Double Helix Fabrication and Characterization of Three-Dimensional Magnetic Nanostructures http://purl.org/coar/resource_type/c_46ec https://orcid.org/0000-0002-5552-8836 Sanz Hernández, Dédalo 2019-07-03 2019-07-03

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We used Gaia Data Release 2 to search for upcoming photometric microlensing events, identifying two candidates with high amplification. In the case of candidate 1, a spectrum of the lens (l1) confirms it is a usdM3 subdwarf with mass ≈0.11M⊙, while the event reaches maximum amplification of $20^{+20}_{-10}$ mmag on 2019 November 3 (±1d). For candidate 2, the lens (l2) is a metal-poor M dwarf with mass ≈0.38M⊙ derived from spectral energy distribution fitting, and maximum amplification of $10^{+40}_{-10}$ mmag occurs on 2019 June 3 (±4d). This permits the use of a new algorithm for mass inference on the microlens. Given the predicted time, the photometric light curve of these events can be sampled by targeted photometric campaigns. The light curve is a function of the unknown lens mass, together with eight other parameters for all of which Gaia provides measurements and uncertainties. Leveraging this prior information on the source and lens provided by Gaia’s astrometric solution, combined with a photometric campaign, we show that the masses of 11 and l2 are likely to be inferred with 20–27 and 30–42 per cent precision, respectively. This mass measurement for l1 will provide an important benchmark for low-mass stars in the halo. We show for both l1 and l2 the precision at which their masses can be inferred will likely be limited by the photometric measurements and not by the priors provided by Gaia Data Release 2. https://www.repository.cam.ac.uk/handle/1810/288597 eng https://doi.org/10.17863/CAM.35879 https://www.repository.cam.ac.uk/bitstreams/d4b7a630-f812-489c-80e0-3ad3cad3ddc6/download 0035-8711 5109 Space Sciences 51 Physical Sciences Microlens mass determination for Gaia’s predicted photometric events http://purl.org/coar/resource_type/c_6501 McGill, P Smith, LC Evans, NW Belokurov, V Zhang, ZH https://doi.org/10.1093/mnras/sty3344 ST/N000927/1 1950369 2019-03-01 Oxford University Press (OUP) 2019-01-31

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Tapping into firm-level accounting data across 90 countries over a 26-year period, we find that sound political institutions are positively associated with corporate risk-taking. This result is economically significant, robust to alternative proxies for corporate risk-taking and political institutions, and continues to hold after mitigating endogeneity concerns of political institutions. We also collect evidence that sound political institutions may compensate for weak legal institutions in inducing corporate risk-taking. We argue that sound political institutions improve the investment environment for firms and can induce higher levels of corporate risk-taking, which is ultimately associated with economic growth. https://www.repository.cam.ac.uk/handle/1810/352854 eng https://doi.org/10.17863/CAM.99048 https://www.repository.cam.ac.uk/bitstreams/ec08225c-b37e-46f2-8949-80ff0a6e4b63/download 1369-412X behavioral theory of the firm firm size legal institution managerial risk-taking profitability Political institutions and corporate risk-taking: International evidence http://purl.org/coar/resource_type/c_6501 2023-06-25 https://orcid.org/0000-0003-3966-3867 Bao, HXH Cardoza, R https://doi.org/10.1111/irfi.12423 ES/P004296/1 2023 Wiley 2023-06-26

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The accession code will be added in Section 2 [...] https://www.repository.cam.ac.uk/handle/1810/329693 eng https://doi.org/10.17863/CAM.77139 https://www.repository.cam.ac.uk/bitstreams/c324f8fa-3c57-4411-8565-121c7f0796b7/download https://www.repository.cam.ac.uk/bitstreams/a96d416b-3fee-47db-a0eb-87716bfe378e/download https://www.repository.cam.ac.uk/bitstreams/ead2eee8-2504-4911-b8d9-4edc789eefbb/download n/a Addendum: Kotál et al. Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement. Int. J. Mol. Sci. 2021, 22, 9480 http://purl.org/coar/resource_type/c_1843 2021-09-22 https://orcid.org/0000-0002-5644-1468 Kotál, Jan https://orcid.org/0000-0002-4210-6677 Polderdijk, Stéphanie G. I. Langhansová, Helena Ederová, Monika https://orcid.org/0000-0001-8127-6276 Martins, Larissa A. Beránková, Zuzana https://orcid.org/0000-0003-0277-140X Chlastáková, Adéla Hajdušek, Ondřej https://orcid.org/0000-0002-7526-1876 Kotsyfakis, Michail Huntington, James A. https://orcid.org/0000-0002-7089-6143 Chmelař, Jindřich https://doi.org/10.3390/ijms222011271 2021-10-19 MDPI 2021-10-21

oai:www.repository.cam.ac.uk:1810/3141762020-12-04T07:48:15Zcom_1810_253889com_1810_243853com_1810_218403com_1810_23com_1810_256063col_1810_253928

https://www.repository.cam.ac.uk/handle/1810/314176 ru https://doi.org/10.17863/CAM.61279 https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/82f80074-1aeb-40d2-941a-b7d1159c0d26/download Whip magical power Sangadzhi Kononov, About the magical power of a whip http://purl.org/coar/resource_type/c_12ce Terbish, Baasanjav Churyumov, Anton Kovaeva, Bair Terbish, Baasanjav 2016-09-01 Kalmyk Cultural Heritage Documentation Project, University of Cambridge 2020-12-03

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EU External Relations Law and Policy significantly evolved since the seminal Singapore Opinion in the Court of Justice (ECJ). This paper analyses the new trade and sustainable development (TSD) policies by the European Union (EU) and highlights how the changes at the EU domestic level in the course of the EU Green Deal have fundamentally changed the outlook for EU external action and even changed EU External Relations Law in the process. The use of constitutional objectives in external relations is now firmly established but the new mix of autonomous and cooperative elements also changes the more fundamental principles on which EU foreign relations are based.While the EU is still finding the right balance between autonomous measures and international cooperation, the new flexibility, particularly to address global sustainable development challenges and in the context of the Sustainable Development Goals (SDGs) allow the EU greater foreign policy flexibility in areas covered by global targets such as the SDGs, the Paris Agreement and the new Convention on Biological Diversity (CBD) Kunming-Montreal Global Biodiversity Framework. It is argued that the existence of global goals and targets combined with EU internal action in the context of the EU Green Deal fundamentally change the availability and legality of EU External Relations Law on Trade and Sustainability. https://www.repository.cam.ac.uk/handle/1810/388120 eng https://doi.org/10.17863/CAM.120610 https://www.repository.cam.ac.uk/bitstreams/86b4e6f2-1ba5-46df-876e-bf4daa1d8d01/download 1384-6299 4408 Political Science 44 Human Society 16 Peace, Justice and Strong Institutions EU External Relations Law on Trade and Sustainable Development: The Evolving Nature of EU Law and Policy Constraints http://purl.org/coar/resource_type/c_6501 W. Gehring, Markus https://doi.org/10.54648/eerr2025008 2025-01-01 Kluwer Law International 2025-08-11

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Work on accents (Abū l-Faraj Hārūn, Hidāyat al-Qāriʾ, longer version?) http://www.dspace.cam.ac.uk/handle/1810/235278 jrb heb https://www.repository.cam.ac.uk/bitstreams/37e8e9cc-c6c1-43e6-9662-35521a966363/download https://www.repository.cam.ac.uk/bitstreams/473322ff-b2c9-4c95-a3e3-ae312a98768b/download https://www.repository.cam.ac.uk/bitstreams/8f620751-2765-40a7-9e71-02967aa6f0f5/download https://www.repository.cam.ac.uk/bitstreams/ab0a2795-7323-4131-ba31-54c0e7b6e250/download https://www.repository.cam.ac.uk/bitstreams/b1106a0b-93aa-46b3-8791-48941c54e6b2/download https://www.repository.cam.ac.uk/bitstreams/fe127cca-1755-4f8c-84f2-6715850344b3/download Genizah MS T-S AS 139.83 http://purl.org/coar/resource_type/c_1843 Unknown 2011-02-25 Taylor-Schechter Genizah Research Unit 2011-02-25

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Sustainable structural materials with excellent impact-resistance properties are urgently needed but challenging to produce, especially in a scalable fashion and with control over 3D shape. Here, we show that bacterial cellulose (BC) and bacterially precipitated calcium carbonate self-assemble into a layered structure reminiscent of tough biomineralized materials in nature (nacre, bone, dentin). The fabrication method consists of biomineralizing BC to form an organic/inorganic mixed slurry, in which calcium carbonate crystal size is controlled with bacterial poly(γ-glutamic acid) and magnesium ions. This slurry self-assembles into a layered material that combines high toughness and high impact and fire resistance. The rapid fabrication is readily scalable, without involving toxic chemicals. Notably, the biomineralized BC can be repeatedly recycled and molded into any desired 3D shape and size using a simple kitchen blender and sieve. This fully biodegradable composite is well suited for use as a component in daily life, including furniture, helmets, and protective garments. https://www.repository.cam.ac.uk/handle/1810/329857 eng https://doi.org/10.17863/CAM.77302 https://www.repository.cam.ac.uk/bitstreams/72562fc9-57f6-4225-9b08-16ca9b70cc33/download 2666-3864 40 Engineering 3403 Macromolecular and Materials Chemistry 4016 Materials Engineering 34 Chemical Sciences Scalable bacterial production of moldable and recyclable biomineralized cellulose with tunable mechanical properties http://purl.org/coar/resource_type/c_6501 2021-05-19 Yu, Kui Spiesz, Ewa M Balasubramanian, Srikkanth Schmieden, Dominik T Meyer, Anne S Aubin-Tam, Marie-Eve https://doi.org/10.1016/j.xcrp.2021.100464 2021-06 Elsevier 2021-10-25

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We describe stereocontrolled semi-syntheses of deguelin and tephrosin, anti-cancer rotenoids isolated from Tephrosia vogelii. Firstly, we present a new two-step transformation of rotenone into rot-2'-enonic acid via a zinc-mediated ring opening of rotenone hydrobromide. Secondly, following conversion of rot-2'-enonic acid into deguelin, a chromium-mediated hydroxylation provides tephrosin as a single diastereoisomer. An Étard-like reaction mechanism is proposed to account for the stereochemical outcome. Our syntheses of deguelin and tephrosin are operationally simple, scalable and high yielding, offering considerable advantages over previous methods. https://www.repository.cam.ac.uk/handle/1810/263759 eng https://doi.org/10.17863/CAM.9131 https://www.repository.cam.ac.uk/bitstreams/5b28c8ad-dd03-4d3c-9066-345eada1430e/download 1477-0520 Molecular Conformation Rotenone Stereoisomerism Stereocontrolled semi-syntheses of deguelin and tephrosin. http://purl.org/coar/resource_type/c_6501 2017-01-24 Russell, David A Freudenreich, Julien J Ciardiello, Joe J Sore, Hannah F https://orcid.org/0000-0001-7355-2824 Spring, David R https://doi.org/10.1039/c6ob02659a EP/J016012/1 279337 EP/K039520/1 EP/P020291/1 2017-02-21 Royal Society of Chemistry (RSC) 2017-04-24

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Mature granulated trophoblast binucleate cells (BNC) have been found in all ruminant placentas examined histologically so far. BNC are normally fairly evenly distributed throughout the fetal villus and all their granules contain a similar variety of hormones and pregnancy associated glycoproteins (PAGs). Only the Giraffe is reported to show a different BNC protein expression, this paper is designed to investigate that. Gold labelled Lectin histochemistry and protein immunocytochemistry were used on deplasticised 1 μm sections of a wide variety of ruminant placentomes with a wide range of antibodies and lectins. In the Giraffe placentomes, even though the lectin histochemistry shows an even distribution of BNC throughout the trophoblast of the placental villi, the protein expression in the BNC granules is limited to the BNC either in the apex or the base of the villi. Placental lactogens and Prolactin (PRL) are present only in basally situated BNC: PAGs only in the apical BNC. PRL is only found in the Giraffe BNC which react with many fewer of the wide range of antibodies used here to investigate the uniformity of protein expression in ruminant BNC. The possible relevance of these differences to ruminant function and evolution is considered to provide a further example of the versatility of the BNC system. https://www.repository.cam.ac.uk/handle/1810/332678.2 eng https://www.repository.cam.ac.uk/bitstreams/20a668f8-a0b3-448d-9135-b0ca7e6fd3d6/download 0006-3363 Giraffe granule protein asymmetry Ruminant placenta Trophoblast binucleate cell Animals Female Giraffes Lectins Placenta Pregnancy Prolactin Ruminants Trophoblasts Asymmetric expression of proteins in the granules of the placentomal Binucleate cells in Giraffa camelopardalis†. http://purl.org/coar/resource_type/c_6501 2022-01-15 Wooding, FBP Forhead, AJ Wilsher, S Allen, WR Roberts, RM Green, JA Beckers, JF Sousa, N Melo Charpigny, G https://doi.org/10.1093/biolre/ioab247 2022-04-26 Oxford University Press (OUP) 2023-10-30

oai:www.repository.cam.ac.uk:1810/2704392025-12-19T17:57:13Zcom_1810_198332com_1810_256064col_1810_214775

https://www.repository.cam.ac.uk/handle/1810/270439 eng https://doi.org/10.17863/CAM.17313 https://www.repository.cam.ac.uk/bitstreams/019442cb-84bc-467a-aa55-f4fbe4ac5035/download Femtosecond time-resolved intersubband relaxation measurements in GaAs/AlGaAs quantum wells. http://purl.org/coar/resource_type/c_46ec Schumacher, Kimberly 1995-06-13 2018-01-10

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Letter. http://www.dspace.cam.ac.uk/handle/1810/234504 jrb heb https://www.repository.cam.ac.uk/bitstreams/5718be3f-721b-448e-8a02-4be5c6fbb0af/download https://www.repository.cam.ac.uk/bitstreams/693056d3-1e47-4e9e-ae94-eb8aeece0760/download https://www.repository.cam.ac.uk/bitstreams/77f66243-1744-4baf-9c47-2e81f772785a/download https://www.repository.cam.ac.uk/bitstreams/7c77a68b-b98f-495e-bda9-dc4d28626b37/download https://www.repository.cam.ac.uk/bitstreams/8313cb8f-8ec8-4788-8aa0-50c85a28b617/download https://www.repository.cam.ac.uk/bitstreams/aa5686e5-19c4-49a8-86ee-9134dd988cd5/download Genizah MS T-S AS 156.214 http://purl.org/coar/resource_type/c_1843 Unknown 2011-02-25 Taylor-Schechter Genizah Research Unit 2011-02-25

oai:www.repository.cam.ac.uk:1810/3101562025-12-19T17:57:15Zcom_1810_751com_1810_256067col_1810_294790

Culture (behaviour based on socially transmitted information) is present in diverse animal species, yet how it interacts with genetic evolution remains largely unexplored. Here, we review the evidence for gene-culture coevolution in animals, especially birds, cetaceans and primates. We describe how culture can relax or intensify selection under different circumstances, create new selection pressures by changing ecology or behaviour, and favour adaptations, including in other species. Finally, we illustrate how, through culturally mediated migration and assortative mating, culture can shape population genetic structure and diversity. This evidence suggests strongly that animal culture plays an important evolutionary role, and we encourage explicit analyses of gene-culture coevolution in nature. https://www.repository.cam.ac.uk/handle/1810/310156 eng https://doi.org/10.17863/CAM.57241 https://www.repository.cam.ac.uk/bitstreams/955803c4-ce05-48d8-a9c4-a21526d49a73/download https://www.repository.cam.ac.uk/bitstreams/2ae976fe-b759-47fc-91ca-9bf031c18be1/download 2041-1723 Animal Migration Animals Behavior, Animal Birds Cetacea Cultural Evolution Ecology Evolution, Molecular Genetic Variation Genetics, Population Primates Sexual Behavior, Animal The reach of gene-culture coevolution in animals. http://purl.org/coar/resource_type/c_6501 2019-05-02 https://orcid.org/0000-0001-5469-3429 Whitehead, Hal Laland, Kevin N https://orcid.org/0000-0002-1121-9142 Rendell, Luke https://orcid.org/0000-0001-5010-2177 Thorogood, Rose https://orcid.org/0000-0003-2426-5890 Whiten, Andrew https://doi.org/10.1038/s41467-019-10293-y 2019-06-03 Springer Nature 2020-09-11

oai:www.repository.cam.ac.uk:1810/328462021-04-22T20:08:44Zcom_1810_274com_1810_256063col_1810_31289

http://www.dspace.cam.ac.uk/handle/1810/32846 eng https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/662037a5-cdc8-4fa4-9b7c-924c5958755e/download P6667 http://purl.org/coar/resource_type/c_c513 Douglas, B 2009-06-26 Kilise Tepe Project 2005-04-27

oai:www.repository.cam.ac.uk:1810/4002062026-03-18T01:40:30Zcom_1810_221783com_1810_256067col_1810_221784

Molecular evolutionary biology seeks to explain the diversity of life by uncovering the processes that shape genomes over time. A central aim within this field is to identify the genetic basis of adaptation, often manifesting as signatures of positive selection acting on protein-coding genes. Detecting such signals sheds light on evolutionary processes such as functional divergence, coevolutionary dynamics and phenotypic innovation. However, whilst the study of natural selection has been foundational in evolutionary theory, reliably identifying its genomic footprints remains a persistent challenge. Traditional methods for detecting interspecific positive selection are grounded in statistical, likelihood-based methods, typically employing codon substitution models. These approaches infer rates of nonsynonymous to synonymous substitutions (dN/dS) from nucleotide multiple sequence alignments (MSAs) of homologous, protein-coding genes, interpreted as a proxy for positive selection. These approaches have been instrumental in advancing our understanding of adaptive evolution, but they are not without their limitations. Statistical approaches are often computationally demanding, vulnerable to model misspecification, and underpowered when applied to realistic evolutionary scenarios. Models are forced to make simplifying assumptions to make the analysis tractable in the likelihood framework, which can contribute to both type I and type II error. Misalignments tend to further inflate false positive inference. As genomic datasets have grown in both scale and complexity, the shortcomings of classical inference methods have become increasingly apparent. This creates a pressing need for approaches that can harness large genomic datasets more flexibly, while capturing the complex dependencies inherent in sequence evolution. In parallel with these challenges, recent advances in machine learning have transformed diverse areas of biology, including molecular evolution. In particular, deep neural network architectures such as convolutional neural networks (CNNs) and transformer models have demonstrated an ability to extract meaningful patterns from raw biological data, without heavy reliance on human-curated features. Nevertheless, applying machine learning to molecular evolution presents its own challenges: the task requires large amounts of biologically realistic training data, architectures and resources equipped to handle such data, and rigorous evaluation frameworks that connect machine learning predictions to established evolutionary theory. There is very little or no evolutionary data for which we know the ground truth regarding how it has evolved; therefore, I rely on simulated data for training and evaluation. This thesis addresses these challenges by developing and evaluating machine learning methods for detecting positive selection in protein-coding genes. I first establish simulation frameworks that can be used to generate training data, and design benchmarking experiments to compare machine learning models against widely used statistical methods. I then develop CNNs trained to classify MSAs as evolving under positive selection or not, which were simulated from constrained phylogenies as a proof-of-principle. These models perform well when tested on data that resemble the training data, but struggle to generalise outside of the target domain. Nonetheless, these CNNs were successful in providing a faster, efficient and more accurate solution for positive selection detection compared to likelihood methods when trained for a specific phylogenetic scenario. This is useful for analyses such as genome-wide selection scans, where many MSAs are associated with the same phylogeny. To address the limitations of CNNs I then switch my focus to developing transformer models, which generalise more effectively across varied phylogenetic scenarios due to their global receptive field (ability to capture long-range dependencies across sequences) and permutation-invariant (insensitivity to the order of input elements) attention mechanism. I compare transformers directly with CNNs, showing comparable performance before extending to generalised models, capable of handling a wide range of phylogenetic scenarios. In addition to binary classification --- where whole genes are inferred to have evolved under positive selection or not --- I develop transformer models that predict sitewise dN/dS values for codon-specific inference of positive selection. To develop these models I evaluate a range of architectures and training strategies. These analyses demonstrate that machine learning approaches can achieve comparable or superior sensitivity to established likelihood-based methods. At the same time, I explore strategies to biologically interpret what these models learn. Exploiting the flexibility of the machine learning framework, I increase the realism of simulations by incorporating more realistic evolutionary processes that cannot typically be used in likelihood-based approaches. Finally, I apply generalised transformer models to empirical datasets. These analyses highlight their utility in cases where statistical methods lack power, while also revealing limitations that point to directions for future development. The contributions of this thesis are threefold. First, I provide an assessment of the limitations of current statistical methods, clarifying where they fall short in practice. Second, I develop new methodological tools that adapt machine learning architectures for evolutionary inference, with particular emphasis on CNNs and transformer models applied to MSAs. Third, I present an evaluation framework that bridges machine learning predictions with evolutionary theory, working towards methodological advances that are robust and biologically meaningful. Together, these contributions demonstrate how machine learning can extend the methodological toolkit of molecular evolution in ways that are difficult to achieve with traditional likelihood-based approaches. Machine learning models learn complex, non-linear patterns directly from data, capture signals of selection that are inaccessible to predefined parametric models, exploit the flexibility of simulation, and scale efficiently to large datasets. This work shows both the promise and the limitations of deep learning for detecting selection, and it points toward a future in which data-driven and theory-driven approaches are integrated to achieve faster, more flexible, and more accurate evolutionary inference. https://www.repository.cam.ac.uk/handle/1810/400206 eng https://doi.org/10.17863/CAM.128461 https://www.repository.cam.ac.uk/bitstreams/37398577-a0d4-4081-913f-8d24013984c3/download machine learning evolution positive selection Machine learning methods for detecting positive selection http://purl.org/coar/resource_type/c_46ec West, Charlotte 2026-03-17 2026-03-17

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State-of-the-art pixels for high-resolution microdisplays utilize refective surfaces on top of electrical backplanes. Each pixel is a single fxed color and will usually only modulate the amplitude of light. With the rise of nanophotonics, a pixel’s relatively large surface area (~10μm$^2$), is in efect underutilized. Considering the unique optical phenomena associated with plasmonic nanostructures, the scope for use in refective pixel technology for increased functionality is vast. Yet in general, low refectance due to plasmonic losses, and sub-optimal design schemes, have limited the real-world application. Here we demonstrate the $\textit{plasmonic metapixel}$; which permits high refection capability whilst providing vivid, polarization switchable, wide color gamut fltering. Ultra-thin nanostructured metal-insulatormetal geometries result in the excitation of hybridized absorption modes across the visible spectrum. These modes include surface plasmons and quasi-guided modes, and by tailoring the absorption modes to exist either side of target wavelengths, we achieve pixels with polarization dependent multicolor refection on mirror-like surfaces. Because the target wavelength is not part of a plasmonic process, subtractive color fltering and mirror-like refection occurs. We demonstrate wide color-range pixels, RGB pixel designs, and in-plane Gaussian profle pixels that have the potential to enable new functionality beyond that of a conventional ‘square’ pixel. https://www.repository.cam.ac.uk/handle/1810/265361 eng https://doi.org/10.17863/CAM.11239 https://www.repository.cam.ac.uk/bitstreams/aff4f47a-beff-4512-9e77-06f8529d7298/download https://www.repository.cam.ac.uk/bitstreams/49d4cff0-c694-4fa6-8e0c-47b4ddc8b058/download https://www.repository.cam.ac.uk/bitstreams/e905ed09-5213-469c-bdc6-d410412a40ec/download 2045-2322 plasmonics optics nanophotonics displays nanotechnology Nanostructured plasmonic metapixels http://purl.org/coar/resource_type/c_6501 2017-07-05 Williams, C Rughoobur, G flewitt, A wilkinson, T https://doi.org/10.1038/s41598-017-08145-0 1241027 21102 24669 EP/L015455/1 2017-08-10 Nature Publishing Group 2017-07-14

oai:www.repository.cam.ac.uk:1810/3901272025-12-19T17:57:18Zcom_1810_751com_1810_256067col_1810_294790

BACKGROUND: Impaired insight can be understood clinically as a loss of ability to appropriately recognize one's own disease status. Investigating insight in Alzheimer's disease (AD) and its relation to longitudinal changes in brain structure is important to understand the disease progression. OBJECTIVE: To examine how the character of insight changes with disease stage and assess whether baseline levels of impaired insight can predict rate of brain atrophy across a period of 30 months in a cohort of subjects consisting of subjective memory complaint (SMC), mild cognitive impairment (MCI), AD, and cognitively normal (CN) controls. METHODS: Data from 794 eligible participants were extracted from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. Insight levels were estimated by the Measurement of Everyday Cognition (ECog). Impairment was further categorized into overestimation or underestimation of ability. Brain atrophy rates were estimated by measuring change in gray matter volume within 30 months. RESULTS: Overestimating ability was significantly correlated with increased whole-brain atrophy rates (p < 0.001) independent of general cognitive decline. Overestimation of ability exhibited significant correlations with increased atrophy in specific regions of the brain including the medial temporal lobe, fusiform gyrus, and hippocampus. DISCUSSION: The present results suggest a statistically significant correlation between overestimation of ability and increased rates of subsequent brain atrophy. This is particularly notable in regions of the brain such as the hippocampus. However, further study into the phenomenon of insight and its progression over the disease course is required before its potential clinical utility can be fully assessed. https://www.repository.cam.ac.uk/handle/1810/390127 eng https://www.repository.cam.ac.uk/bitstreams/fde5e4c3-1b78-410f-b0f5-60a81d7a72ce/download https://www.repository.cam.ac.uk/bitstreams/d3e5559e-e1ce-4954-b69a-ce82c619ca37/download 2157-9032 Humans Alzheimer Disease Atrophy Male Aged Female Cognitive Dysfunction Brain Longitudinal Studies Disease Progression Aged, 80 and over Magnetic Resonance Imaging Cohort Studies Cognition Gray Matter Neuroimaging Baseline Impaired Insight Predicts Longitudinal Brain Atrophy in Alzheimer's Disease and Related Cognitive States: A 30-Month Cohort Study From the ADNI Dataset. http://purl.org/coar/resource_type/c_6501 2025-09-01 https://orcid.org/0009-0001-4848-6236 Wilkins, Jacob Neira, Carlos Muñoz Su, Li Alzheimer's Disease Neuroimaging Initiative https://doi.org/10.1002/brb3.70893 NIHR203321 to C.M.N. and L.S. ARUK‐SRF2017B‐1 to L.S. 2025-10 Wiley 2025-09-30

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BACKGROUND: The purpose of this study was to investigate the therapeutic efficacy of intravenously administered immunoselected STRO-3 + mesenchymal precursor cells (MPCs) on clinical scores, joint pathology and cytokine production in an ovine model of monoarthritis. METHODS: Monoarthritis was established in 16 adult merino sheep by administration of bovine type II collagen into the left hock joint following initial sensitization to this antigen. After 24 h, sheep were administered either 150 million allogeneic ovine MPCs (n = 8) or saline (n = 8) intravenously (IV). Lameness, joint swelling and pain were monitored and blood samples for leukocytes and cytokine levels were collected at intervals following arthritis induction. Animals were necropsied 14 days after arthritis induction and gross and histopathological evaluations were undertaken on tissues from the arthritic (left) and contralateral (right) joints. RESULTS: MPC-treated sheep demonstrated significantly reduced clinical signs of lameness, joint pain and swelling compared with saline controls. They also showed decreased cartilage erosions, synovial stromal cell activation and angiogenesis. This was accompanied by decreased infiltration of the synovial tissues by CD4⁺ lymphocytes and CD14⁺ monocytes/macrophages. Over the 3 days following joint arthropathy induction, the numbers of neutrophils circulating in the blood and plasma concentrations of activin A were significantly reduced in animals administered MPCs. CONCLUSIONS: The results of this study have demonstrated the capacity of IV-administered MPCs to mitigate the clinical signs and some of the inflammatory mediators responsible for joint tissue destruction in a large animal model of monoarthritis. https://www.repository.cam.ac.uk/handle/1810/262980 eng https://doi.org/10.17863/CAM.8283 https://www.repository.cam.ac.uk/bitstreams/a7fac7db-c150-4cf4-8a5c-a0f63df90288/download https://www.repository.cam.ac.uk/bitstreams/502df10a-c45d-4cfe-a137-66fe79f77e0a/download 1757-6512 Animal model Collagen-induced arthritis Mesenchymal stem cells Neutrophils Immunoselected STRO-3(+) mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. http://purl.org/coar/resource_type/c_6501 2016-12-15 Abdalmula, A Dooley, LM Kaufman, C Washington, EA House, JV https://orcid.org/0000-0001-5454-6496 Blacklaws, Barbara Ghosh, P Itescu, S Bailey, SR Kimpton, WG https://doi.org/10.1186/s13287-016-0460-7 2017-02-07 BioMed Central 2017-03-09

oai:www.repository.cam.ac.uk:1810/2969352025-12-19T17:57:20Zcom_1810_229649com_1810_751com_1810_256067col_1810_368714

BACKGROUND: Smoking in pregnancy is a major international public health problem. Self-help support (SHS) increases the likelihood of women stopping smoking in pregnancy and delivering this kind of support by text message could be a cost-effective way to deliver SHS to pregnant women who smoke. SHS delivered by text message helps non-pregnant smokers to stop but the currently available message programmes are not appropriate for use in pregnancy. A randomised controlled trial (RCT) has demonstrated the feasibility and acceptability of using a programme called 'MiQuit' to text SHS support to pregnant women who smoke. Another pilot RCT has shown that it would be feasible to run a larger, multi-centre trial within the UK National Health Service (NHS). The aim of this third RCT is to complete MiQuit's evaluation, demonstrating whether or not this is efficacious for smoking cessation in pregnancy. METHODS/DESIGN: This is a multi-centre, parallel-group RCT. Pregnant women aged over 16 years, of less than 25 weeks' gestation who smoke one or more daily cigarettes but smoked at least five daily cigarettes before pregnancy and who understand written English and are being identified in 24 English antenatal care hospitals. Participants are randomised to control or intervention groups in a 1:1 ratio stratified by gestation (< 16 weeks versus ≥ 16 weeks). All participants receive a leaflet on stopping smoking during pregnancy; they are also able to access standard NHS smoking cessation support. Intervention group women also receive the 12-week MiQuit programme of tailored, interactive text message, and self-help cessation support. Women are followed up by telephone at 4 weeks after randomisation and 36 weeks' gestation. The RCT will recruit 692 women (346 per group), enabling a 95% confidence interval for the difference in quit rates to be estimated within ± 3%. To determine whether or not MiQuit helps pregnant smokers to stop, intervention group quit rates from this trial will be combined with those from the two earlier trials in a Trial Sequential Analysis (TSA) meta-analysis to derive a pooled efficacy estimate. DISCUSSION: If effective, MiQuit will be a cheap, cost-effective method to help pregnant women to stop smoking. TRIAL REGISTRATION: ClinicalTrials.gov, ID: NCT03231553 . Registered on 20 July 2017. https://www.repository.cam.ac.uk/handle/1810/296935 eng https://doi.org/10.17863/CAM.43976 https://www.repository.cam.ac.uk/bitstreams/09593d5a-b325-433f-8adf-9dba2fbcfddd/download 1468-6708 Pregnancy Protocol Randomised controlled trial Self-help Smoking cessation Female Humans Pregnancy Cost-Benefit Analysis Data Management Follow-Up Studies Outcome Assessment, Health Care Randomized Controlled Trials as Topic Sample Size Self-Help Groups Single-Blind Method Smoking Cessation Text Messaging Multicenter Studies as Topic Meta-Analysis as Topic Effectiveness and cost-effectiveness of a tailored text-message programme (MiQuit) for smoking cessation in pregnancy: study protocol for a randomised controlled trial (RCT) and meta-analysis. http://purl.org/coar/resource_type/c_6501 2019-04-02 https://orcid.org/0000-0002-7599-8640 Whitemore, Rachel Leonardi-Bee, Jo Naughton, Felix Sutton, Stephen Cooper, Sue Parrott, Steve Hewitt, Catherine Clark, Miranda Ussher, Michael Jones, Matthew Torgerson, David Coleman, Tim https://doi.org/10.1186/s13063-019-3341-4 2019-05-22 Springer Nature 2019-09-18

oai:www.repository.cam.ac.uk:1810/3882342025-12-19T17:57:21Zcom_1810_751com_1810_256067col_1810_294790

https://www.repository.cam.ac.uk/handle/1810/388234 eng https://www.repository.cam.ac.uk/bitstreams/11ae4e1a-f273-41ca-a690-50f9e49ec4bb/download https://www.repository.cam.ac.uk/bitstreams/fc8e98e1-3757-4373-9aa3-280f1cb04647/download https://www.repository.cam.ac.uk/bitstreams/23da5b31-7c12-4f46-8299-3a49fbde28d2/download 2095-5138 A new in situ method for modifying the Schottky barrier height at buried metal–organic semiconductor interfaces http://purl.org/coar/resource_type/c_1843 2025-06-19 Sirringhaus, Henning https://doi.org/10.1093/nsr/nwaf252 2025-06-20 Oxford University Press 2025-08-13

oai:www.repository.cam.ac.uk:1810/3749282025-12-19T17:57:22Zcom_1810_229649com_1810_751com_1810_256067col_1810_368714

We introduce a notion of local Hilbert–Schmidt stability, motivated by the recent definition by Bradford of local permutation stability, and give examples of (non-residually finite) groups that are locally Hilbert–Schmidt stable but not Hilbert–Schmidt stable. For amenable groups, we provide a criterion for local Hilbert–Schmidt stability in terms of group characters, by analogy with the character criterion of Hadwin and Shulman for Hilbert–Schmidt stable amenable groups. Furthermore, we study the (very) flexible analogues of local Hilbert–Schmidt stability, and we prove several results analogous to the classical setting. Finally, we prove that infinite sofic, respectively hyperlinear, property (T) groups are never locally permutation stable, respectively locally Hilbert–Schmidt stable. This strengthens the result of Becker and Lubotzky for classical stability, and answers a question of Lubotzky. https://www.repository.cam.ac.uk/handle/1810/374928 eng https://doi.org/10.17863/CAM.112801 https://www.repository.cam.ac.uk/bitstreams/13a352fb-9a72-41c5-9fcf-61028a2712c1/download 0021-8693 4904 Pure Mathematics 49 Mathematical Sciences Local Hilbert–Schmidt stability http://purl.org/coar/resource_type/c_6501 2024-10-07 Fournier-Facio, Francesco Gerasimova, Maria Spaas, Pieter https://doi.org/10.1016/j.jalgebra.2024.08.042 2025-02 Elsevier 2024-10-22

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Sitting in a tea house, Alan Macfarlane paints a picture of Manchester and Liverpool in the 1830s and the consequences for general health and living conditions, in conversation with Ian Duncan. http://www.dspace.cam.ac.uk/handle/1810/581 eng https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/a425f39a-fe80-46df-9624-ad770d8dd021/download industrial revolution epidemic over-crowding slums The nature of early cities in Britain and the effects on health http://purl.org/coar/resource_type/c_12ce Macfarlane, Alan 2004-08-05 2004-08-05

oai:www.repository.cam.ac.uk:1810/3629132025-12-19T17:57:22Zcom_1810_229649com_1810_751com_1810_256067col_1810_368714

Unlike state-building in medieval Europe, America, and Africa, where a combination of security threats and economic incentives led to a swift consolidation of central authority, post-war Europe has lacked an essential ingredient of successful state-building: an existential threat. The result, argue Keleman and McNamara, has been a ‘gradual, uneven, and dysfunctional’ integration process, stopping short of statehood. Ironically, their comparative historical explanation for the EU's shortcomings is strangely ‘ahistorical’, failing to consider the specific world-historical time at which the EU was born. The EU emerged at a time when (a) existing nation-states were relatively solidly formed, and (b) the territorial state is increasingly anachronistic as a means of amassing and projecting power. In a globalized world, providing for citizens’ security and welfare demands global alliance-building more than coercive taxation to build large standing armies. War-deprivation is therefore not what explains the EU’s limited statehood. As security threats loom on the EU’s borders, concentration of fiscal capacity and coercive power in Brussels remains unlikely. The good news is that – by historical standards – the EU appears to be managing external crises remarkably well with limited ‘core state powers’. https://www.repository.cam.ac.uk/handle/1810/362913 eng https://doi.org/10.17863/CAM.104825 https://www.repository.cam.ac.uk/bitstreams/1f1efcfb-0dc4-4c12-9531-ea8b91396014/download 1350-1763 4408 Political Science 44 Human Society 16 Peace, Justice and Strong Institutions The anachronism of bellicist state-building http://purl.org/coar/resource_type/c_6501 Eilstrup-Sangiovanni, Mette https://doi.org/10.1080/13501763.2022.2141825 2022-12-02 Taylor & Francis 2024-01-04

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Over the past fifteen years, one- and two-dimensional nanostructures have drawn intense attention across a range of scientific fields. For optoelectronic device applications these nanomaterials are particularly attractive due to their fundamental physical properties, such as dramatic environmental or photo-sensitivity, and effects arising from their sub-wavelength dimensions. Furthermore, their physical size alone presents an opportunity for their use as nanoscale components within miniaturised or flexible systems. In this thesis, optoelectronic device platforms based around two such nanomaterial systems – compositionally-engineered nanowires and layered black phosphorus – are developed and studied. An ultra-miniaturised microspectrometer device platform is demonstrated, based on individual compositionally-engineered nanowires. Representing the most compact microspectrometer design to date, by over two orders of magnitude, this strategy is independent of the complex optical components, cavities or CCDs that constrain further miniaturisation of current systems. It is demonstrated that incident spectra can be computationally reconstructed from the different spectral response functions and measured photocurrents along these nanowires. This platform is highly versatile; operation can straightforwardly be expanded across the infrared to ultraviolet range. Despite their simplicity, these devices are capable of accurate monochromatic and broadband light reconstruction, as well as spectral imaging from centimetre-scale image planes down to lensless, single-cell-scale in-situ mapping. This could open new opportunities for almost any miniaturised spectroscopic application, including lab-on-a-chip systems, smartphones, drones, implants, and wearable devices. Further to this, the first scalable strategy for depositing solution-processed black phosphorus films with viable device performance and stability is demonstrated. High concentration black phosphorus dispersions are produced by liquid-phase-exfoliation. Optimisation of a solvent-exchange method facilitates conversion of these dispersions into inks, which can be reliably inkjet printed to produce highly uniform black phosphorus films without significant flake degradation. Parylene-C encapsulation of these films ensures their long-term stability (>30 days) when incorporated into photodetectors and lasers, operating under intense irradiation without any observed drop in performance over time. https://www.repository.cam.ac.uk/handle/1810/315521 eng https://doi.org/10.17863/CAM.62628 https://www.repository.cam.ac.uk/bitstreams/acb18da4-fb87-4e5a-9e7c-89743c7ca44c/download Nanotechnology Nanowires 2d Materials Semiconductor Engineering Applied Physics Optoelectronics Spectrometers Photodetection and Spectrometry at the Nanoscale http://purl.org/coar/resource_type/c_46ec https://orcid.org/0000-0003-0443-014X Albrow-Owen, Thomas 1577735 2020-12-23 2020-12-23

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Inspired by Kenbib’s Les Protégés (1996) this article will develop an exploration of the way Spanish protectorate scholars used musicology to “look” at their Jewish protégés in Morocco and how traces of this scholarly gaze remain in place until today. Through an exploration of various works from the time of the protectorate and others from after Independence, I will show how protectorate tropes continue to operate within the manners in which the Spanish study and sometimes ignore the music of Moroccan Jews. Some will claim Jewish music for their own nationalistic projects, others disengage from Moroccan Jewish repertoires, showing a general political indifference towards the cultural and intellectual particularity of Jews and most importantly the very Moroccan experience of their musical expression. https://www.repository.cam.ac.uk/handle/1810/308828 eng https://doi.org/10.17863/CAM.55916 https://www.repository.cam.ac.uk/bitstreams/7f3d6995-9b03-47db-bfc6-ac795c2b4502/download https://www.repository.cam.ac.uk/bitstreams/f8a4fec4-c92e-48f2-b459-b11b5eadc7b0/download Looking at the 'Other' through the Ear: Contemporary Traces of Protectorate Politics through Music http://purl.org/coar/resource_type/c_1843 2020-08-03 https://orcid.org/0000-0002-8144-4652 Duncan, Vanessa https://doi.org/10.17863/CAM.55916 758221 2020-08-05 Université Mohammed V of Rabat, Morocco. Faculté des lettres et sciences humaines 2020-08-05

oai:www.repository.cam.ac.uk:1810/2632162025-12-19T17:57:29Zcom_1810_721com_1810_256064col_1810_218856

The aggregation of alpha-synuclein (αS) protein from soluble monomer into solid amyloid fibrils in the brain is associated with a range of devastating neurodegenerative disorders such as Parkinson’s disease. Soluble oligomers formed during the aggregation process are highly neurotoxic and are thought to play a key role in the onset and spreading of disease. Despite their importance, these species are difficult to study by conventional experimental approaches owing to their transient nature, heterogeneity, low abundance and a remarkable sensitivity of the oligomerisation process to the chosen experimental conditions. In this thesis, well-established single-molecule techniques have been utilised to study the aggregation and oligomerisation of αS in solution. https://www.repository.cam.ac.uk/handle/1810/263216 eng https://doi.org/10.17863/CAM.8525 https://www.repository.cam.ac.uk/bitstreams/d0a198a3-bec6-468d-8aa4-96a4af28c77e/download alpha-synuclein single-molecule FRET protein aggregation neurodegeneration Aggregation of alpha-synuclein using single-molecule spectroscopy http://purl.org/coar/resource_type/c_46ec Iljina, Marija 2017-03-23 Department of Chemistry, University of Cambridge 2017-03-24

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INTRODUCTION: This study aimed to investigate the impact of anaemia on long-term clinical outcomes in patients who underwent semi-urgent and elective percutaneous coronary intervention (PCI) in an Asian population. Although the effects of anaemia on outcomes in Asian patients are well studied for acute coronary syndrome, its impact on Asian patients undergoing semi-urgent and elective PCI is unclear. METHODS: This was a retrospective cohort study of patients who underwent semi-urgent and elective PCI from January 1, 2014, to December 31, 2015, at a tertiary academic centre. A total of 1,685 patients were included. They were stratified into three groups: normal (≥12 g/dL), intermediate (10-11.9 g/dL), and low (<10 g/dL) haemoglobin levels. Demographics, risk factors, and end-points including the 5-point major adverse cardiac and cerebrovascular events (MACCE) (all-cause death, subsequent stroke, myocardial infarction, congestive cardiac failure, and target lesion revascularisation), cardiovascular death, and bleeding events were analysed. RESULTS: Patients in intermediate and low haemoglobin level groups were older with more comorbidities. Compared to the normal haemoglobin level group, low haemoglobin level group patients were associated with an increased risk of composite endpoints of all-cause death, subsequent stroke, myocardial infarction, congestive cardiac failure, and target lesion revascularisation [adjusted hazard ratio (aHR) 1.89, 95% confidence interval (CI):1.22, 2.92; p = 0.004]. This was driven by the increased risk of target lesions revascularisation observed in the low haemoglobin level group compared to the normal haemoglobin level group (aHR 17.74, 95% CI: 1.74, 180.80; p = 0.015). The patients in the low haemoglobin level group were also associated with a higher risk of bleeding events compared to the normal haemoglobin level group (aHR 7.18, 95% CI: 1.13, 45.40; p = 0.036). CONCLUSION: In our Asian cohort, patients with anaemia undergoing PCI were associated with a higher comorbid burden. Despite adjustments for comorbidities, these patients had higher mortality and worse cardiovascular outcomes following contemporary PCI. https://www.repository.cam.ac.uk/handle/1810/335655 eng https://doi.org/10.17863/CAM.83085 https://www.repository.cam.ac.uk/bitstreams/bf9e0678-0326-44cb-baf7-b130be31082a/download https://www.repository.cam.ac.uk/bitstreams/ce32a650-81e7-47a2-9edc-789888f7d466/download https://www.repository.cam.ac.uk/bitstreams/549e1c00-6356-46f4-861e-8dfe4e0b83ea/download 2297-055X Asian anaemia bleeding event cardiovascular outcomes percutaneous coronary intervention Clinical Characteristics and Long-Term Outcomes of Patients With Differing Haemoglobin Levels Undergoing Semi-Urgent and Elective Percutaneous Coronary Intervention in an Asian Population. http://purl.org/coar/resource_type/c_6501 2022-02-17 Soh, Rodney Yu-Hang Sia, Ching-Hui Djohan, Andie Hartanto Lau, Rui-Huai Ho, Pei-Ying Neo, Jonathan Wen-Hui Ho, Jamie Sin-Ying Sim, Hui-Wen Yeo, Tiong-Cheng Tan, Huay-Cheem Chan, Mark Yan-Yee Loh, Joshua Ping-Yun https://doi.org/10.3389/fcvm.2022.687555 2022 Frontiers 2022-04-01

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OBJECTIVES: To investigate the longitudinal trends of decompressive craniectomy (DC) following traumatic brain injury (TBI) or stroke and explore whether the timing of cranial reconstruction affected revision or removal rates using Hospital Episode Statistics (HES) between 2014 and 2019. DESIGN: Retrospective observational cohort study using HES. The time frame definitions mirror those often used in clinical practice. SETTING: HES data from neurosurgical centres in England. PARTICIPANTS: HES data related to decompressive craniectomy procedures and cranioplasty following TBI or stroke between 2014 and 2019. MAIN OUTCOME MEASURES: The primary outcome was the timing and rate of revision/removal compared with cranioplasty within <12 weeks to ≥12 weeks. RESULTS: There were 4627 DC procedures, of which 1847 (40%) were due to head injury, 1116 (24%) were due to stroke, 728 (16%) were due to other cerebrovascular diagnoses, 317 (7%) had mixed diagnosis and 619 (13%) had no pre-specified diagnoses. The number of DC procedures performed per year ranged from 876 in 2014-2015 to 967 in 2018-2019. There were 4466 cranioplasty procedures, with 309 (7%) revisions and/or removals during the first postoperative year. There was a 33% increase in the overall number of cranioplasty procedures performed within 12 weeks, and there were 1823 patients who underwent both craniectomy and cranioplasty during the study period, with 1436 (79%) having a cranioplasty within 1 year. However, relating to the timing of cranial reconstruction, there was no evidence of any difference in the rate of revision or removal surgery in the early timing group (6.5%) compared with standard care (7.9%) (adjusted HR 0.93, 95% CIs 0.61 to 1.43; p=0.75). CONCLUSIONS: Overall number of craniectomies and the subsequent requirements for cranioplasty increased steadily during the study period. However, relating to the timing of cranial reconstruction, there was no evidence of an overall difference in the rate of revision or removal surgery in the early timing group. https://www.repository.cam.ac.uk/handle/1810/369493 eng https://www.repository.cam.ac.uk/bitstreams/f6aaf79d-efe2-4acf-915a-c263748e83fe/download https://www.repository.cam.ac.uk/bitstreams/49d40cb3-5363-4df4-8f3c-e4ca780cb53b/download 2631-4940 Cohort Study Decompressive craniectomy to cranioplasty: a retrospective observational study using Hospital Episode Statistics in England. http://purl.org/coar/resource_type/c_6501 2024-05-13 https://orcid.org/0000-0002-1314-3962 Mee, Harry Harris, JM Korhonen, T Anwar, F Wahba, AJ Martin, Michael Whiting, G Viaroli, E Timofeev, I Helmy, A https://orcid.org/0000-0003-3992-0587 Kolias, Angelos G Hutchinson, Peter J https://doi.org/10.1136/bmjsit-2023-000253 G0802251/1 2024 BMJ 2024-06-10

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A key feature of coordination cages is the dynamic nature of their coordinative bonds, which facilitates the synthesis of complex polyhedral structures and their post-assembly modification. However, this dynamic nature can limit cage stability. Increasing cage robustness is important for real-world use cases. Here we introduce a double-bridging strategy to increase cage stability, where designed pairs of bifunctional subcomponents combine to generate rectangular tetratopic ligands within pseudo-cubic Zn8L6 cages. These cages withstand transmetalation, the addition of competing ligands, and nucleophilic imines, under conditions where their single-bridged congeners decompose. Our approach not only increases the stability and robustness of the cages while maintaining their polyhedral structure, but also enables the incorporation of additional functional units in proximity to the cavity. The double-bridging strategy also facilitates the synthesis of larger cages, which are inaccessible as single-bridged congeners. https://www.repository.cam.ac.uk/handle/1810/376259 eng https://www.repository.cam.ac.uk/bitstreams/3b16984d-490a-4788-8d18-30b4f7979ed5/download https://www.repository.cam.ac.uk/bitstreams/cd0569af-07ed-4cd4-ba0f-a5c7c9347045/download https://www.repository.cam.ac.uk/bitstreams/3d29e564-251b-4dd1-bdad-8f7678c46176/download 0002-7863 3402 Inorganic Chemistry 3403 Macromolecular and Materials Chemistry 34 Chemical Sciences Generic health relevance Double-Bridging Increases the Stability of Zinc(II) Metal-Organic Cages. http://purl.org/coar/resource_type/c_6501 2024-10-09 Kurz, Hannah https://orcid.org/0000-0002-2571-8161 Teeuwen, Paula CP https://orcid.org/0000-0002-6917-3685 Ronson, Tanya K Hoffman, Jack B https://orcid.org/0000-0002-8495-9504 Pracht, Philipp Wales, David J https://orcid.org/0000-0002-4060-5122 Nitschke, Jonathan R https://doi.org/10.1021/jacs.4c09742 EP/S024220/1 EP/T031603/1 2024-11-13 American Chemical Society (ACS) 2024-11-14

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Plural valuation is about eliciting the diverse values of nature articulated by different stakeholders in order to inform decision making and thus achieve more equitable and sustainable outcomes. We explore what approaches align with plural valuation on the ground, as well as how different social-ecological contexts play a role in translating plural valuation into decisions and outcomes. Based on a co-constructed analytical approach relying on empirical information from ten cases from the Global South, we find that plural valuation contributes to equitable and sustainable outcomes if the valuation process: 1) is based on participatory value elicitation approaches; 2) is framed with a clear action-oriented purpose; 3) provides space for marginalized stakeholders to articulate their values in ways that can be included in decisions; 4) is used as a tool to identify and help reconcile different cognitive models about human-nature relations; and 5) fosters open communication and collaboration among stakeholders. We also find that power asymmetries can hinder plural valuation. As interest and support for undertaking plural valuation grows, a deeper understanding is needed regarding how it can be adapted to different purposes, approaches, and social-ecological contexts in order to contribute to social equity and sustainability. https://www.repository.cam.ac.uk/handle/1810/308281 eng https://doi.org/10.17863/CAM.55372 https://www.repository.cam.ac.uk/bitstreams/88a56ae6-0b31-490c-9568-6e4edf406af9/download 0959-3780 38 Economics 3801 Applied Economics Plural valuation of nature for equity and sustainability: Insights from the Global South http://purl.org/coar/resource_type/c_6501 Zafra-Calvo, Noelia Balvanera, Patricia Pascual, Unai Merçon, Juliana Martín-López, Berta van Noordwijk, Meine Mwampamba, Tuyeni Heita Lele, Sharachchandra Speranza, Chinwe Ifejika Arias-Arévalo, Paola Cabrol, Diego Cáceres, Daniel M O'Farrell, Patrick Subramanian, Suneetha Mazhenchery Devy, Soubadra Krishnan, Siddhartha https://orcid.org/0000-0001-8607-4147 Carmenta, Rachel Guibrunet, Louise Kraus-Elsin, Yoanna Moersberger, Hannah Cariño, Joji Díaz, Sandra https://doi.org/10.1016/j.gloenvcha.2020.102115 2020-07 Elsevier 2020-07-22

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The provision of essential public services—water, energy, health, housing, education, transport, social care and infrastructure—is a crucial determinant of successful regional socio-economic development. Public services favour community wellbeing, render places more attractive, fuel regional productivity and employment, help ameliorate inter-regional and urban-rural inequalities and play a key role in environmental sustainability (OECD, 2023). Their provision, therefore, should be at he heart of any successful regional development policy. In the post-war period, many countries – though with some important exceptions – brought such public services and utilities under state ownership (ie nationalised them) on the grounds of ensuring ‘universality’ of provision (in some cases as part of a new ‘social contract’ between states and their populations), ‘consistency’ (equal access and standards in every locality and region) and ‘efficiency’ (securing economies of scale). https://www.repository.cam.ac.uk/handle/1810/403430 eng https://doi.org/10.17863/CAM.130388 https://www.repository.cam.ac.uk/bitstreams/38be6676-62ca-4b35-82a7-2654f9c2e090/download 1752-1378 How Places are Contesting the Privatisation of Local Public Services http://purl.org/coar/resource_type/c_6501 2026-05-15 https://orcid.org/0000-0002-1002-0879 Gray, Mia Martin, Ron Clifton, Judith McDonald, David 2026-05-22 Cambridge Political Economy Society 2026-05-22

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Few examples in the literature offer approaches to improve skills or solve the problems that will inevitably arise while working with the often limited resources available in archaeological excavations. Clearly, working in the field is very different from working in the controlled environment of a laboratory. Even very simple things may be difficult to achieve. This poster explores -- in a light-hearted but fully grounded way -- how conservators overcame apparently mundane challenges when trying to use cyclododecane during the 2014 excavation season in Olduvai Gorge, an important Palaeolithic site in Tanzania, where material resources were limited. We demonstrate how much preparation and improvisation are needed to make things work properly and safely. https://www.repository.cam.ac.uk/handle/1810/292122 eng https://doi.org/10.17863/CAM.39275 https://www.repository.cam.ac.uk/bitstreams/fa4d7963-79fe-4304-b825-e63a66f1b5d2/download Juggling fire without getting burned: working with cyclododecane in Olduvai Gorge http://purl.org/coar/resource_type/c_c94f Rozeik, Christina Peters, Renata F Ohara Anderson, Eri https://doi.org/10.17863/CAM.39275 2019-03-01 University of Cambridge Museums 2019-04-30

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This paper presents a full procedure for the development of a Part-of-Speech (POS) tagged corpus of Old Catalan. As an extremely low-resource language with rich inflection and frequent homographs, Old Catalan poses non-trivial problems in the development of a searchable constituency-based treebank. We demonstrate, however, that a semi-supervised method of incrementally building training data using both neural and memory-based taggers, together with the Pyrrha annotation tool is highly efficient and yields accurate results. We propose that this simple and effective method could easily be extended to other low-resource historical languages for which no NLP tools exist yet. https://www.repository.cam.ac.uk/handle/1810/331671.2 eng https://www.repository.cam.ac.uk/bitstreams/42db5db7-91ab-4b62-865e-31bcb78d5b06/download 2059-481X 46 Information and Computing Sciences 47 Language, Communication and Culture 4704 Linguistics Old Catalan Morphosyntax: Developing an Annotated Corpus http://purl.org/coar/resource_type/c_6501 2021-10-25 https://orcid.org/0000-0003-0395-8372 Meelen, Marieke Pujol I Campeny, Afra https://doi.org/10.5334/johd.54 PF170063 SRG18R1\181450 2024-08-13 Ubiquity Press 2024-08-13

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This chapter addresses the challenges of evaluating the business case for continuous manufacturing of pharmaceuticals, looking beyond traditional technical assessments made at the unit operations or individual production facility level. It provides an overview of key concepts, approaches and tools for the early assessment of supply network configuration opportunities enabled by continuous production processing interventions. Multiple levels of analysis are considered with the aid of examples based on major UK research programmes on continuous production process technologies. Particular emphasis is placed on the potential for achieving enhanced product flexibility (in terms of volume and variety) and depending on scale, the optimum number and location of manufacturing operations to support speed to market and system-level cost benefits. In the case of multiple manufacturing operations using continuous production process technologies, where production facility replication through digital twins is becoming a key enabler, the chapter sets out a supply network design and analysis approach that evaluates the commercial and operational viability of alternative manufacturing supply network scenarios. https://www.repository.cam.ac.uk/handle/1810/337078 eng https://doi.org/10.17863/CAM.84497 https://www.repository.cam.ac.uk/bitstreams/ac1b7e3a-d021-4e2c-b03e-fe75bcc53f34/download 978-3-030-41524-2 3509 Transportation, Logistics and Supply Chains 4014 Manufacturing Engineering 40 Engineering 35 Commerce, Management, Tourism and Services Generic health relevance 9 Industry, Innovation and Infrastructure Evaluating the Business Case for Continuous Manufacturing of Pharmaceuticals: A Supply Network perspective http://purl.org/coar/resource_type/c_1843 Nagy, Z El Hagrasy, A Litster, J Srai, jagjit https://orcid.org/0000-0001-5174-9423 Settanni, Ettore Aulakh, parminder https://doi.org/10.1007/978-3-030-41524-2_14 EP/I033459/1 35708-233529 EP/P006965/1 2020 Springer 2022-05-12

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Abstract Hollow‐core photonic crystal fibers (HC‐PCFs) provide a novel approach for in situ UV/Vis spectroscopy with enhanced detection sensitivity. Here, we demonstrate that longer optical path lengths than afforded by conventional cuvette‐based UV/Vis spectroscopy can be used to detect and identify the Co I and Co II states in hydrogen‐evolving cobaloxime catalysts, with spectral identification aided by comparison with DFT‐simulated spectra. Our findings show that there are two types of signals observed for these molecular catalysts; a transient signal and a steady‐state signal, with the former being assigned to the Co I state and the latter being assigned to the Co II state. These observations lend support to a unimolecular pathway, rather than a bimolecular pathway, for hydrogen evolution. This study highlights the utility of fiber‐based microreactors for understanding these and a much wider range of homogeneous photocatalytic systems in the future. https://www.repository.cam.ac.uk/handle/1810/345479 eng https://doi.org/10.17863/CAM.92902 https://www.repository.cam.ac.uk/bitstreams/74cb6b9a-6d02-4cf7-bd21-636a9af9dac0/download https://www.repository.cam.ac.uk/bitstreams/7c8f0d73-d2c2-4d80-8a63-99a8ef236eb5/download 0044-8249 34 Chemical Sciences 3406 Physical Chemistry 7 Affordable and Clean Energy In situ Detection of Cobaloxime Intermediates During Photocatalysis Using Hollow‐Core Photonic Crystal Fiber Microreactors http://purl.org/coar/resource_type/c_6501 2022-12-06 https://orcid.org/0000-0002-2571-4216 Lawson, Takashi https://orcid.org/0000-0003-3830-2488 Gentleman, Alexander S Pinnell, Jonathan Eisenschmidt, Annika https://orcid.org/0000-0001-5466-2921 Antón‐García, Daniel https://orcid.org/0000-0002-8857-0029 Frosz, Michael H https://orcid.org/0000-0002-7781-1616 Reisner, Erwin https://orcid.org/0000-0002-8305-9598 Euser, Tijmen G https://doi.org/10.1002/ange.202214788 RPG-2018-256 EP/S022953/1 EP/M508007/1 EP/L015978/1 1948662 1948662 2023-02-20 Wiley 2023-01-18

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Multiple trapping and release (MTR) is a typical charge transport mechanism associated with localized states in technologically important disordered semiconductors such as hydrogenated amorphous silicon (a-Si:H) and many amorphous oxides. However, till now the analysis of MTR has been built on an “abrupt” mobility edge model. Using electron transport as an example, the abrupt mobility edge model assumes that: (i) states above the conduction band (CB) mobility edge (EC ) are extended and any of them is omnipresent in space, whereas states below EC are localized and they exist in the energy-space diagram as pointlike sites; (ii) all states are evenly distributed in space. The prequel to this paper [Y. Luo and A. Flewitt, Phys. Rev. B 109, 104203 (2024)] demonstrates that neither of these simplifications is valid. Hence, this paper reinvestigates MTR transport. Through a probabilistic analysis of the microscopic charge transport details, this paper rigorously achieves two critical conclusions that challenge previous beliefs. First, the mobility edge, which is characterizable through activation energy measurement of conductivity, is an effective quantity associated with carrier relaxation dynamics; it does not demarcate the extended states and localized states of an amorphous semiconductor. Second, the extended-state mobility, which is extractable from time-of-flight experiments, is also an effective quantity that is higher than the mobility of free carriers in the material. https://www.repository.cam.ac.uk/handle/1810/379825 eng https://doi.org/10.17863/CAM.115796 https://www.repository.cam.ac.uk/bitstreams/c7d5ab04-0242-425f-9e5d-be14446c2e20/download 0022-3093 51 Physical Sciences 5104 Condensed Matter Physics Revisiting multiple trapping and release charge transport in amorphous semiconductors exemplified by hydrogenated amorphous silicon http://purl.org/coar/resource_type/c_6501 2025-02-05 Luo, Yuezhou Flewitt, Andrew John https://doi.org/10.1016/j.jnoncrysol.2025.123436 https://doi.org/10.1080/13642818508240550 EP/W009757/1 2025-04 Elsevier 2025-02-15

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C4 photosynthesis has evolved repeatedly from the ancestral C3 state to generate a carbon concentrating mechanism that increases photosynthetic efficiency. This specialized form of photosynthesis is particularly common in the PACMAD clade of grasses, and is used by many of the world's most productive crops. The C4 cycle is accomplished through cell-type-specific accumulation of enzymes but cis-elements and transcription factors controlling C4 photosynthesis remain largely unknown. Using the NADP-Malic Enzyme (NADP-ME) gene as a model we tested whether mechanisms impacting on transcription in C4 plants evolved from ancestral components found in C3 species. Two basic Helix-Loop-Helix (bHLH) transcription factors, ZmbHLH128 and ZmbHLH129, were shown to bind the C4NADP-ME promoter from maize. These proteins form heterodimers and ZmbHLH129 impairs trans-activation by ZmbHLH128. Electrophoretic mobility shift assays indicate that a pair of cis-elements separated by a seven base pair spacer synergistically bind either ZmbHLH128 or ZmbHLH129. This pair of cis-elements is found in both C3 and C4 Panicoid grass species of the PACMAD clade. Our analysis is consistent with this cis-element pair originating from a single motif present in the ancestral C3 state. We conclude that C4 photosynthesis has co-opted an ancient C3 regulatory code built on G-box recognition by bHLH to regulate the NADP-ME gene. More broadly, our findings also contribute to the understanding of gene regulatory networks controlling C4 photosynthesis. https://www.repository.cam.ac.uk/handle/1810/275352 eng https://doi.org/10.17863/CAM.22542 https://www.repository.cam.ac.uk/bitstreams/536cb73d-1c85-477b-8184-86ff36442724/download https://www.repository.cam.ac.uk/bitstreams/19097fb2-844c-490b-bcd4-99038ef1a578/download 0737-4038 Basic Helix-Loop-Helix Proteins Gene Expression Regulation, Plant Malate Dehydrogenase Photosynthesis Plant Proteins Promoter Regions, Genetic Zea mays Synergistic Binding of bHLH Transcription Factors to the Promoter of the Maize NADP-ME Gene Used in C4 Photosynthesis Is Based on an Ancient Code Found in the Ancestral C3 State. http://purl.org/coar/resource_type/c_6501 2018-03-28 Borba, Ana Rita Serra, Tânia S Górska, Alicja Gouveia, Paulo Cordeiro, André M Reyna-Llorens, Ivan Knerová, Jana Barros, Pedro M Abreu, Isabel A Oliveira, Maria Margarida Hibberd, Julian M Saibo, Nelson JM https://doi.org/10.1093/molbev/msy060 BB/L014130/1 206409 289582 2018-07-01 Oxford University Press (OUP) 2018-04-30

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<jats:title>Abstract</jats:title><jats:p>Surface melting occurs across many of Antarctica’s ice shelves, mainly during the austral summer. The onset, duration, area and fate of surface melting varies spatially and temporally, and the resultant surface meltwater is stored as ponded water (lakes) or as slush (saturated firn or snow), with implications for ice-shelf hydrofracture, firn air content reduction, surface energy balance and thermal evolution. This study applies a machine-learning method to the entire Landsat 8 image catalogue to derive monthly records of slush and ponded water area across 57 ice shelves between 2013 and 2021. We find that slush and ponded water occupy roughly equal areas of Antarctica’s ice shelves in January, with inter-regional variations in partitioning. This suggests that studies that neglect slush may substantially underestimate the area of ice shelves covered by surface meltwater. Furthermore, we found that adjusting the surface albedo in a regional climate model to account for the lower albedo of surface meltwater resulted in 2.8 times greater snowmelt across five representative ice shelves. This extra melt is currently unaccounted for in regional climate models, which may lead to underestimates in projections of ice-sheet melting and ice-shelf stability.</jats:p> https://www.repository.cam.ac.uk/handle/1810/368470 eng https://doi.org/10.17863/CAM.108656 https://www.repository.cam.ac.uk/bitstreams/89c94769-7b76-457c-98e2-ef32de637934/download 1752-0894 37 Earth Sciences 3709 Physical Geography and Environmental Geoscience 13 Climate Action Substantial contribution of slush to meltwater area across Antarctic ice shelves http://purl.org/coar/resource_type/c_6501 2024-05-10 https://orcid.org/0000-0001-6617-3906 Dell, Rebecca L https://orcid.org/0000-0002-0750-7088 Willis, Ian C https://orcid.org/0000-0001-7538-3999 Arnold, Neil S https://orcid.org/0000-0001-9545-829X Banwell, Alison F https://orcid.org/0000-0001-8830-9894 de Roda Husman, Sophie https://doi.org/10.1038/s41561-024-01466-6 NE/T006234/1 1841607 2213702 2024-05-24 Springer Science and Business Media LLC 2024-05-24

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This review summarises some of the key features of interstitial lung diseases (ILDs) from a translational science point of view and brings insights into potential therapeutic options. Genetic predisposition and environmental factors like smoking, pollution and infections significantly impact the onset, progression and treatment response in ILDs, highlighting the need for personalised management. Fibroblasts are central to ILD pathology, influencing the tissue microenvironment, immune cell interactions and extracellular matrix (ECM) production, making them critical therapeutic targets. Monocyte-derived M2 macrophages drive fibrosis in idiopathic pulmonary fibrosis by secreting cytokines and remodelling the ECM. Understanding macrophage subtypes and their dynamics offers new therapeutic possibilities. Chronic type 2 immunity contributes to fibrosis, emphasising the need to enhance protective markers in order to even out the balance shift of pathological immune responses in ILD treatments. Serum biomarkers like Krebs von den Lungen-6 (KL-6), surfactant protein (SFTP) D, matrix metalloproteinase-7 (MMP-7), and C-C motif chemokine ligand (CCL)-18 are valuable for diagnosing and predicting ILD progression, although more research is needed for clinical application. Animal models, especially bleomycin-based models, offer insights into ILD pathology, but challenges like lung hyperinflation highlight the need for careful model selection and translational research to bridge preclinical and clinical findings. https://www.repository.cam.ac.uk/handle/1810/384887 eng https://www.repository.cam.ac.uk/bitstreams/802f980b-ed97-4ce4-ac81-264c6b70aa8c/download 1810-6838 32 Biomedical and Clinical Sciences 3204 Immunology Lung Precision Medicine Pulmonary Fibrosis 2.1 Biological and endogenous factors 4.1 Discovery and preclinical testing of markers and technologies Respiratory Inflammatory and immune system 3 Good Health and Well Being Insights into interstitial lung disease pathogenesis. http://purl.org/coar/resource_type/c_6501 2025-03-11 https://orcid.org/0000-0003-0747-0227 Vasarmidi, Eirini Worrell, Julie C https://orcid.org/0000-0001-5959-3777 Mahmutovic Persson, Irma Yaqub, Naheem Miądlikowska, Ewa Barnig, Cindy Boots, Agnes Reynaert, Niki L https://orcid.org/0000-0002-8326-5279 Cuevas Ocaña, Sara https://doi.org/10.1183/20734735.0261-2024 2025-04 European Respiratory Society (ERS) 2025-05-29

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© ESO, 2017. Aims. We search for runaway former companions of the progenitors of nearby Galactic core-collapse supernova remnants (SNRs) in the Tycho-Gaia astrometric solution (TGAS). Methods. We look for candidates among a sample of ten SNRs with distances 2kpc, taking astrometry and G magnitude from TGAS and B,V magnitudes from the AAVSO Photometric All-Sky Survey (APASS). A simple method of tracking back stars and finding the closest point to the SNR centre is shown to have several failings when ranking candidates. In particular, it neglects our expectation that massive stars preferentially have massive companions. We evolve a grid of binary stars to exploit these covariances in the distribution of runaway star properties in colour - magnitude - ejection velocity space. We construct an analytic model which predicts the properties of a runaway star, in which the model paramet ers are the location in the grid of progenitor binaries and the properties of the SNR. Using nested sampling we calculate the Bayesian evidence for each candidate to be the runaway and simultaneously constrain the properties of that runaway and of the SNR itself. Results. We identify four likely runaway companions of the Cygnus Loop (G074.0-08.5), HB 21 (G089.0+ 04.7), S147 (G180.0+ 01.7) and the Monoceros Loop (G205.5+ 00.5). HD 37424 has previously been suggested as the companion of S147, however the other three stars are new candidates. The favoured companion of HB 21 is the Be star BD+50 3188 whose emission-line features could be explained by pre-supernova mass transfer from the primary. There is a small probability that the 2M candidate runaway TYC 2688-1556-1 associated with the Cygnus Loop is a hypervelocity star. If the Monoceros Loop is related to the on-going star formation in the Mon OB2 association, the progenitor of the Monoceros Loop is required to be more massive than 40M which is in tension with the posterior for our candidate runaway star HD 261393. https://www.repository.cam.ac.uk/handle/1810/269537 eng https://doi.org/10.17863/CAM.11371 https://www.repository.cam.ac.uk/bitstreams/703fec1a-45bd-401d-b7df-57e851e4d0c2/download https://www.repository.cam.ac.uk/bitstreams/0d30c8fa-84d3-4060-8f52-e23a73a8512d/download 0004-6361 supernovae: general binaries: close ISM: supernova remnants methods: statistical stars: emission-line, Be Binary companions of nearby supernova remnants found with Gaia http://purl.org/coar/resource_type/c_6501 2017-07-03 Boubert, D Fraser, M Evans, NW Green, DA Izzard, RG https://doi.org/10.1051/0004-6361/201731142 ST/L003910/1 ST/N000927/1 320360 1634398 2017-10-01 EDP Sciences 2017-11-22

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BACKGROUND: The SPEEDY study was set up to quantify levels of physical activity (PA) and dietary habits and the association with potential correlates in 9-10 year old British school children. We present here the analyses of the PA, dietary and anthropometry data. METHODS: In a cross-sectional study of 2064 children (926 boys, 1138 girls) in Norfolk, England, we collected anthropometry data at school using standardised procedures. Body mass index (BMI) was used to define obesity status. PA was assessed with the Actigraph accelerometer over 7 days. A cut-off of > or = 2000 activity counts was used to define minutes of moderate-to-vigorous PA (MVPA). Dietary habits were assessed using the Health Behaviour in School Children food questionnaire. Weight status was defined using published international cut-offs (Cole, 2000). Differences between groups were assessed using independent t-tests for continuous data and chi-squared tests for categorical data. RESULTS: Valid PA data (>500 minutes per day on > or = 3 days) was available for 1888 children. Mean (+/- SD) activity counts per minute among boys and girls were 716.5 +/- 220.2 and 635.6 +/- 210.6, respectively (p < 0.001). Boys spent an average of 84.1 +/- 25.9 minutes in MVPA per day compared to 66.1 +/- 20.8 among girls (p < 0.001), with an average of 69.1% of children accumulating 60 minutes each day. The proportion of children classified as overweight and obese was 15.0% and 4.1% for boys and 19.3% and 6.6% for girls, respectively (p = 0.001). Daily consumption of at least one portion of fruit and of vegetables was 56.8% and 49.9% respectively, with higher daily consumption in girls than boys and in children from higher socioeconomic backgrounds. CONCLUSION: Results indicate that almost 70% of children meet national PA guidelines, indicating that a prevention of decline, rather than increasing physical activity levels, might be an appropriate intervention target. Promotion of daily fruit and vegetable intake in this age group is also warranted, possibly focussing on children from lower socioeconomic backgrounds. http://www.dspace.cam.ac.uk/handle/1810/237939 eng https://www.repository.cam.ac.uk/bitstreams/00ec08e5-26bc-4fa1-acd9-87128ff79250/download https://www.repository.cam.ac.uk/bitstreams/c3c823a7-ecb7-48d5-9177-93b86936f318/download 1472-698X Anthropometry Child Cross-Sectional Studies Diet England Exercise Female Humans Male Physical activity and dietary behaviour in a population-based sample of British 10-year old children: the SPEEDY study (Sport, Physical activity and Eating behaviour: environmental Determinants in Young people). http://purl.org/coar/resource_type/c_6501 2008-11-14 van Sluijs, Esther MF Skidmore, Paula ML Mwanza, Kim Jones, Andrew P Callaghan, Alison M Ekelund, Ulf Harrison, Flo Harvey, Ian https://orcid.org/0000-0001-8870-718X Panter, Jenna Wareham, Nicolas J Cassidy, Aedin Griffin, Simon J https://doi.org/10.1186/1471-2458-8-388 ES/G007462/1 G0501294 MC_UU_12015/1 MC_UU_12015/4 MC_UU_12015/3 087636/Z/08/Z MC_U106179471 MC_U106179474 MC_U106179473 G0501294/1 2008-11-14 Springer Nature 2011-06-16

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Cancer is characterized by cell heterogeneity and the development of 3D $\textit{in vitro }$ assays that can distinguish more invasive or migratory phenotypes could enhance diagnosis or drug discovery. 3D collagen scaffolds have been used to develop analogues of complex tissues $\textit{in vitro }$ and are suited to routine biochemical and immunological assays. We sought to increase 3D model tractability and modulate the migration rate of seeded cells using an ice-templating technique to create either directional/anisotropic or non-directional/isotropic porous architectures within cross-linked collagen scaffolds. Anisotropic scaffolds supported the enhanced migration of an invasive breast cancer cell line MDA-MB-231 with an altered spatial distribution of proliferative cells in contrast to invasive MDA-MB-468 and non-invasive MCF-7 cells lines. In addition, MDA-MB-468 showed increased migration upon epithelial-to-mesenchymal transition (EMT) in anisotropic scaffolds. The provision of controlled architecture in this system may act both to increase assay robustness and as a tuneable parameter to capture detection of a migrated population within a set time, with consequences for primary tumour migration analysis. The separation of invasive clones from a cancer biomass with in vitro platforms could enhance drug development and diagnosis testing by contributing assay metrics including migration rate, as well as modelling cell-cell and cell-matrix interaction in a system compatible with routine histopathological testing. https://www.repository.cam.ac.uk/handle/1810/262024 eng https://doi.org/10.17863/CAM.7262 https://www.repository.cam.ac.uk/bitstreams/c581085f-8b43-4562-b1f9-8f86e0853525/download https://www.repository.cam.ac.uk/bitstreams/d2945ce7-0350-4e10-b1d2-69d957cb5127/download 0142-9612 breast cancer three dimensional migration collagen 1 ice-templating technique scaffold architecture invasion Development of three-dimensional collagen scaffolds with controlled architecture for cell migration studies using breast cancer cell lines http://purl.org/coar/resource_type/c_6501 2016-10-28 Campbell, JJ Husmann, A Hume, RD Watson, CJ Cameron, RE https://doi.org/10.1016/j.biomaterials.2016.10.048 NC/K001655/1 MR/K011014/1 BB/H006206/1 320598 2017-01-01 Elsevier 2017-01-25

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We study the extent to which spin assignments of new particles produced at the LHC can be deduced in the decay of a scalar or fermion C into a new stable (or quasi-stable) particle A through the chain C ! B±q,B± ! AW±,W± ! ℓ±νℓ where ℓ = e, μ. All possible spin assignments of the particles A and B are considered. Explicit invariant mass distributions of the quark and lepton are given for each set of spins, valid for all masses. We also construct the asymmetry between the chains with a W− and those with a W+. The Kullback-Leibler distance between the distributions is then calculated to give a quantitative measure of our ability to distinguish the different spin assignments. http://www.dspace.cam.ac.uk/handle/1810/224188 eng https://www.repository.cam.ac.uk/bitstreams/5754decf-2e5b-4e19-8f47-5138744c6f34/download Spin correlations in decay chains involving W bosons http://purl.org/coar/resource_type/c_6501 Smillie, Jennifer M 2006-09 High Energy Physics, Cavendish Laboratory, University of Cambridge 2010-01-25

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Distorted olivines of enigmatic origin are ubiquitous in erupted products from a wide range of volcanic systems (e.g., Hawai'i, Iceland, Andes). Investigation of these features at Kīlauea Volcano, Hawai'i, using an integrative crystallographic and chemical approach places quantitative constraints on mush pile thicknesses. Electron backscatter diffraction (EBSD) reveals that the microstructural features of distorted olivines, whose chemical composition is distinct from undistorted olivines, are remarkably similar to olivines within deformed mantle peridotites, but inconsistent with an origin from dendritic growth. This, alongside the spatial distribution of distorted grains and the absence of adcumulate textures, suggests that olivines were deformed within melt-rich mush piles accumulating within the summit reservoir. Quantitative analysis of subgrain geometry reveals that olivines experienced differential stresses of ∼3-12 MPa, consistent with their storage in mush piles with thicknesses of a few hundred metres. Overall, our microstructural analysis of erupted crystals provides novel insights into mush-rich magmatic systems. https://www.repository.cam.ac.uk/handle/1810/301886 eng https://doi.org/10.17863/CAM.48954 https://www.repository.cam.ac.uk/bitstreams/c1708c97-6908-4b75-96ad-7430b5db6ac7/download 2041-1723 Microstructural constraints on magmatic mushes under Kīlauea Volcano, Hawai'i. http://purl.org/coar/resource_type/c_6501 https://orcid.org/0000-0002-1070-8323 Wieser, Penny E https://orcid.org/0000-0003-1243-137X Edmonds, Marie Maclennan, John https://orcid.org/0000-0002-7576-4465 Wheeler, John https://doi.org/10.1038/s41467-019-13635-y 2020-01-07 2020-02-09

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Extraintestinal pathogenic Escherichia coli (ExPEC) is the leading cause of urinary tract infections (UTIs) worldwide and may be transmitted from food animals to humans via contaminated meat. However, the contribution of zoonotic ExPEC strains to UTIs in metropolitan areas remains unclear. We estimated the proportion of UTIs attributable to zoonotic ExPEC across eight Southern California counties. Between 2017 and 2021, we collected 12,616 E. coli isolates from retail meat and 23,483 from UTI patients, sequencing a representative subset of 5,728 isolates. Using a Bayesian latent class model trained with 17 host-associated genetic markers, we inferred the host origin of each isolate. Demographic, clinical, and antimicrobial resistance profiles were compared between meat isolates and clinical isolates inferred to be of human or food-animal origin. Most UTI patients were female (88%), with a median age of 50 years; 37% were Hispanic and 31% non-Hispanic white. Zoonotic ExPEC strains accounted for 18% of UTIs overall, rising to 21.5% in high-poverty neighborhoods. Women had a higher zoonotic proportion than men (19.7% vs 8.5%, P < 0.001). Among men, those with zoonotic infections were older than those with non-zoonotic infections (median 73.0 vs 65.0 years, P = 0.028). These findings underscore the contribution of zoonotic ExPEC to the UTI burden in Southern California and the need for targeted interventions to reduce risk in vulnerable communities.IMPORTANCEUrinary tract infections (UTIs) are among the most common bacterial infections worldwide and are primarily caused by Escherichia coli. While E. coli is known to colonize both humans and food-producing animals, the extent to which zoonotic strains impact human disease remains poorly understood. Emerging evidence suggests that food animals may serve as an underrecognized reservoir for extraintestinal pathogenic E. coli (ExPEC). In this study, we used a genomic attribution model to quantify the contribution of zoonotic strains to UTIs in Southern California. We found that approximately 18% of E. coli UTIs were likely attributable to food animals. Individuals living in high-poverty neighborhoods had a 1.6-fold increased risk of zoonotic UTIs compared to those in low-poverty areas. These findings highlight zoonotic transmission as an important driver of UTIs and suggest that reducing ExPEC in food-animal reservoirs could help lower disease burden and address health disparities. https://www.repository.cam.ac.uk/handle/1810/391825 eng https://www.repository.cam.ac.uk/bitstreams/0c1d1c9c-a85e-4690-932c-184f7373d5a0/download 2161-2129 Bayesian latent class model Escherichia coli antimicrobial resistance extraintestinal pathogenic E. coli genomic attribution model urinary tract infection zoonotic infections Humans California Urinary Tract Infections Female Escherichia coli Infections Male Animals Middle Aged Adult Zoonoses Aged Escherichia coli Young Adult Adolescent Meat Child, Preschool Extraintestinal Pathogenic Escherichia coli Child Aged, 80 and over Infant Anti-Bacterial Agents Bacterial Zoonoses Zoonotic Escherichia coli and urinary tract infections in Southern California. http://purl.org/coar/resource_type/c_6501 2025-07-28 https://orcid.org/0000-0002-8347-5487 Aziz, Maliha https://orcid.org/0000-0001-5139-5397 Park, Daniel E Quinlivan, Vanessa Dimopoulos, Evangelos A Wang, Yashan Sung, Edward H Roberts, Annie LS Nyaboe, Ann Davis, Meghan F Casey, Joan A Caballero, Julio Diaz Nachman, Keeve E Takhar, Harpreet S Aanensen, David M https://orcid.org/0000-0002-7069-5958 Parkhill, Julian Tartof, Sara Y Liu, Cindy M https://orcid.org/0000-0002-8746-5307 Price, Lance B KP & GWU ARES team https://doi.org/10.1128/mbio.01428-25 2025-11-12 American Society for Microbiology 2025-11-05

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Urban planners and other stakeholders often view trees as the ultimate panacea for mitigating urban heat stress; however, their cooling efficacy varies globally and is influenced by three primary factors: tree traits, urban morphology, and climate conditions. This study analyzes 182 studies on the cooling effects of urban trees across 17 climates in 110 global cities or regions. Tree implementation reduces peak monthly temperatures to below 26 °C in 83% of the cities. Trees can lower pedestrian-level temperatures by up to 12 °C through large radiation blockage and transpiration. In tropical, temperate, and continental climates, a mixed-use of deciduous and evergreen trees in open urban morphology provides approximately 0.5 °C more cooling than a single species approach. In arid climates, evergreen species predominate and demonstrate more effective cooling within compact urban morphology. Our study offers context-specific greening guidelines for urban planners to harness tree cooling in the face of global warming. https://www.repository.cam.ac.uk/handle/1810/376564 eng https://doi.org/10.17863/CAM.113755 https://www.repository.cam.ac.uk/bitstreams/d5ff956f-d0c3-434a-9cf7-92851ef25439/download 2662-4435 Cooling efficacy of trees across cities is determined by background climate, urban morphology, and tree trait http://purl.org/coar/resource_type/c_6501 2024-11-14 Li, Haiwei Zhao, Yongling Wang, Chenghao Ürge-Vorsatz, Diana Carmeliet, Jan https://orcid.org/0000-0001-5336-4084 Bardhan, Ronita 2024-11-26 Nature Portfolio 2024-11-26

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Choice of the most suitable material out of the universe of engineering materials available to the designers is a complex task. It often requires a compromise, involving conflicts between different design objectives. Materials selection for optimum design of a Micro-Electro-Mechanical-Systems (MEMS) pressure sensor is one such case. For optimum performance, simultaneous maximization of deflection of a MEMS pressure sensor diaphragm and maximization of its resonance frequency are two key but totally conflicting requirements. Another limitation in material selection of MEMS/Microsystems is the lack of availability of data containing accurate micro-scale properties of MEMS materials. This paper therefore, presents a material selection case study addressing these two challenges in optimum design of MEMS pressure sensors, individually as well as simultaneously, using Ashby’s method. First, data pertaining to micro-scale properties of MEMS materials has been consolidated and then the Performance and Material Indices that address the MEMS pressure sensor’s conflicting design requirements are formulated. Subsequently, by using the micro-scale materials properties data, candidate materials for optimum performance of MEMS pressure sensors have been determined. Manufacturability of pressure sensor diaphragm using the candidate materials, pointed out by this study, has been discussed with reference to the reported devices. Supported by the previous literature, our analysis re-emphasizes that silicon with 110 crystal orientation [Si (110)], which has been extensively used in a number of micro-scale devices and applications, is also a promising material for MEMS pressure sensor diaphragm. This paper hence identifies an unexplored opportunity to use Si (110) diaphragm to improve the performance of diaphragm based MEMS pressure sensors. https://www.repository.cam.ac.uk/handle/1810/296702 eng https://doi.org/10.17863/CAM.43744 https://www.repository.cam.ac.uk/bitstreams/3c39fdfe-6fe9-4399-a2d8-008c15892807/download 0946-7076 40 Engineering 4016 Materials Engineering 4009 Electronics, Sensors and Digital Hardware Material selection for optimum design of MEMS pressure sensors http://purl.org/coar/resource_type/c_6501 2019-07-30 Mehmood, Zahid Haneef, Ibraheem Udrea, Florin https://doi.org/10.1007/s00542-019-04601-1 SP-225 2020-09 Springer Nature 2019-09-10

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Given a polytope P in $\mathbb{R}^n$, we say that P has a positive semidefinite lift (psd lift) of size d if one can express P as the linear projection of an affine slice of the positive semidefinite cone $\mathbf{S}^d_+$. If a polytope P has symmetry, we can consider equivariant psd lifts, i.e. those psd lifts that respect the symmetry of P. One of the simplest families of polytopes with interesting symmetries are regular polygons in the plane, which have played an important role in the study of linear programming lifts (or extended formulations). In this paper we study equivariant psd lifts of regular polygons. We first show that the standard Lasserre/sum-of-squares hierarchy for the regular N-gon requires exactly ceil(N/4) iterations and thus yields an equivariant psd lift of size linear in N. In contrast we show that one can construct an equivariant psd lift of the regular 2^n-gon of size 2n-1, which is exponentially smaller than the psd lift of the sum-of-squares hierarchy. Our construction relies on finding a sparse sum-of-squares certificate for the facet-defining inequalities of the regular 2^n-gon, i.e., one that only uses a small (logarithmic) number of monomials. Since any equivariant LP lift of the regular 2^n-gon must have size 2^n, this gives the first example of a polytope with an exponential gap between sizes of equivariant LP lifts and equivariant psd lifts. Finally we prove that our construction is essentially optimal by showing that any equivariant psd lift of the regular N-gon must have size at least logarithmic in N. https://www.repository.cam.ac.uk/handle/1810/266381 eng https://doi.org/10.17863/CAM.9715 https://www.repository.cam.ac.uk/bitstreams/ccc24100-4e06-460d-b2fb-ccf567a429c3/download 0364-765X math.OC math.OC cs.CC cs.CG math.CO Equivariant semidefinite lifts of regular polygons http://purl.org/coar/resource_type/c_6501 2016-06-14 Fawzi, H Saunderson, J Parrilo, PA https://doi.org/10.1287/moor.2016.0813 2017-05 Institute for Operations Research and the Management Sciences 2017-08-15

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<jats:title>SUMMARY</jats:title> <jats:p>Large language models (LLMs) like OpenAI’s ChatGPT, Google’s Gemini and Anthropic’s Claude can be useful tools in psychiatric practice, helping with tasks such as searching for information, managing administrative work and supporting education. This article demystifies how these tools work by explaining their core operational principles and noting their key limitations, including the risks of confabulation (fabricating information), sycophancy and knowledge cut-offs. It provides practical guidance on mitigating these risks through structured ‘prompt engineering’ and offers a safety framework for integrating LLMs into low-risk administrative and educational workflows. The article stresses the importance of approaching these technologies with caution by independently verifying information, adhering to UK data protection laws and upholding the principles of best practice in patient care. The goal is to help clinicians use these powerful but fallible technologies wisely, ensuring that patient safety and professional responsibility remain paramount as they explore these new tools.</jats:p> https://www.repository.cam.ac.uk/handle/1810/393449 eng https://www.repository.cam.ac.uk/bitstreams/50d54c4f-a3fc-4e3d-9264-5806e26b6160/download https://www.repository.cam.ac.uk/bitstreams/1ce114d4-62b0-497f-866d-ceb80a6552a5/download https://www.repository.cam.ac.uk/bitstreams/8f5bb852-440a-4973-ae41-b74de3f605ad/download 2056-4678 electronic health records Machine learning methods medical technology health informatics statistical methodology Navigating the new frontier: psychiatrist’s guide to using large language models in daily practice http://purl.org/coar/resource_type/c_6501 2025-11-03 https://orcid.org/0000-0001-6845-5894 Krishnadas, Rajeev Thilakan, Vineeth https://doi.org/10.1192/bja.2025.10186 2025-12-04 Royal College of Psychiatrists 2025-12-04

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This article presents doubly differential measurements of the asymmetries in production rates between mesons containing a charm quark and those containing an anti-charm quark in proton-proton collisions at a centre-of-mass energy of s=13.6$$ \sqrt{s}=13.6 $$ TeV using data recorded by the LHCb experiment. The asymmetries of D0, D+ and Ds+$$ {D}_s^{+} $$ mesons are measured for two-dimensional intervals in transverse momentum and pseudorapidity, within the range 2.5 < pT< 25.0 GeV/c and 2.0 < η < 4.5. No significant production asymmetries are observed. Comparisons to the Pythia 8 and Herwig 7 event generators are also presented, and their agreement with the data is evaluated. These measurements constitute the first measurements of production asymmetries at this centre-of-mass energy of colliding beams, and the first measurements with the LHCb Run 3 detector. https://www.repository.cam.ac.uk/handle/1810/390800 eng https://www.repository.cam.ac.uk/bitstreams/a53ffce9-fa4e-4948-aa16-545cfdf216b1/download https://www.repository.cam.ac.uk/bitstreams/b7692c99-0175-412e-9be1-01a521dcb65e/download 1126-6708 5106 Nuclear and Plasma Physics 5107 Particle and High Energy Physics 4902 Mathematical Physics 49 Mathematical Sciences 51 Physical Sciences Measurements of charmed meson and antimeson production asymmetries at s=13.6 TeV http://purl.org/coar/resource_type/c_6501 2025-08-08 https://orcid.org/0000-0003-0533-1952 Aaij, R https://orcid.org/0000-0001-7905-0542 Abdelmotteleb, ASW https://orcid.org/0009-0009-0869-6798 Abellan Beteta, C https://orcid.org/0000-0002-6737-3528 Abudinén, F https://orcid.org/0000-0002-5951-3498 Ackernley, T 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https://orcid.org/0000-0002-6273-0506 Andreianov, A https://orcid.org/0000-0002-3923-431X Andreola, P https://orcid.org/0000-0003-2918-1311 Andreotti, M https://orcid.org/0000-0001-6288-0558 Andreou, D https://orcid.org/0000-0002-6191-934X Anelli, A https://orcid.org/0000-0003-1647-4238 Ao, D https://orcid.org/0000-0002-1779-6813 Archilli, F https://orcid.org/0009-0006-3169-0077 Argenton, M https://orcid.org/0000-0003-4234-7005 Arguedas Cuendis, S https://orcid.org/0000-0002-2785-2233 Artamonov, A https://orcid.org/0000-0002-5991-7273 Artuso, M https://orcid.org/0000-0003-3286-683X Aslanides, E https://orcid.org/0009-0005-1667-2666 Ataíde Da Silva, R https://orcid.org/0000-0002-3208-3336 Atzeni, M https://orcid.org/0000-0001-9090-4254 Audurier, B https://orcid.org/0000-0002-1249-367X Bacher, D https://orcid.org/0000-0002-3721-4876 Bachiller Perea, I https://orcid.org/0000-0002-1186-3894 Bachmann, S https://orcid.org/0000-0001-5996-2747 Bachmayer, M https://orcid.org/0000-0001-7791-4490 Back, JJ https://orcid.org/0000-0003-4240-2094 Baladron Rodriguez, P https://orcid.org/0000-0002-1611-7188 Balagura, V https://orcid.org/0009-0003-8872-976X Balboni, A https://orcid.org/0000-0001-7658-8777 Baldini, W https://orcid.org/0009-0006-5241-1452 Balzani, L https://orcid.org/0009-0002-7027-021X Bao, H https://orcid.org/0000-0002-4442-5372 Baptista de Souza Leite, J https://orcid.org/0009-0001-1805-6219 Barbero Pretel, C https://orcid.org/0000-0002-6704-6914 Barbetti, M https://orcid.org/0000-0002-3226-8672 Barbosa, IR https://orcid.org/0000-0002-8295-8612 Barlow, RJ https://orcid.org/0009-0000-0102-0482 Barnyakov, M https://orcid.org/0000-0002-0898-6551 Barsuk, S https://orcid.org/0000-0002-9264-4799 Barter, W https://orcid.org/0000-0002-2646-4124 Bartz, J https://orcid.org/0000-0001-5860-8770 Basels, JM https://orcid.org/0000-0001-9861-8922 Bashir, S https://orcid.org/0000-0003-1020-2549 Batsukh, B https://orcid.org/0009-0005-5095-0439 Battista, PB https://orcid.org/0000-0002-4862-9399 Bay, A https://orcid.org/0000-0003-4872-1213 Beck, A https://orcid.org/0000-0002-7972-8760 Becker, M https://orcid.org/0000-0002-8315-2119 Bedeschi, F https://orcid.org/0000-0001-7806-5283 Bediaga, IB https://orcid.org/0000-0003-4750-7872 Behling, NA https://orcid.org/0000-0001-7154-1304 Belin, S https://orcid.org/0000-0003-0014-2589 Belous, K https://orcid.org/0000-0003-1699-9202 Belov, I https://orcid.org/0000-0002-7458-7030 Belyaev, I https://orcid.org/0000-0002-8176-8315 Benane, G https://orcid.org/0000-0002-5107-0610 Bencivenni, G https://orcid.org/0000-0002-9510-8414 Ben-Haim, E https://orcid.org/0000-0002-4431-7582 Berezhnoy, A https://orcid.org/0000-0002-4856-8063 Bernet, R https://orcid.org/0000-0002-4515-7541 Bernet Andres, S https://orcid.org/0000-0003-1393-4315 Bertolin, A https://orcid.org/0000-0001-9886-7427 Betancourt, C https://orcid.org/0000-0002-2395-235X Betti, F https://orcid.org/0000-0002-2856-8074 Bex, J Bezshyiko, Ia https://orcid.org/0000-0001-7106-5213 Bezshyyko, O https://orcid.org/0000-0002-9709-903X Bhom, J https://orcid.org/0000-0001-7113-7862 Bieker, MS https://orcid.org/0000-0003-3004-0946 Biesuz, NV https://orcid.org/0000-0001-5433-9876 Billoir, P https://orcid.org/0000-0001-6064-9993 Biolchini, A https://orcid.org/0000-0001-9157-4461 Birch, M https://orcid.org/0000-0002-0023-3897 Bishop, FCR https://orcid.org/0000-0001-7979-1092 Bitadze, A https://orcid.org/0000-0001-5729-5530 Bizzeti, A https://orcid.org/0000-0002-0259-5891 Blake, T https://orcid.org/0000-0001-5775-3132 Blanc, F https://orcid.org/0000-0002-6546-5605 Blank, JE https://orcid.org/0000-0001-9170-684X Blusk, S Bocharnikov, V Boelhauve, JA Boente Garcia, O Boettcher, T Bohare, A Boldyrev, A Bolognani, CS Bolzonella, R Bonacci, RB Bondar, N Bordelius, A Borgato, F Borghi, S Borsato, M Borsuk, JT Bottalico, E Bouchiba, SA Bovill, M Bowcock, TJV Boyer, A Bozzi, C Brandenburg, JD Brea Rodriguez, A Breer, N Brodzicka, J Brossa Gonzalo, A Brown, J Brundu, D Buchanan, E Buonincontri, L Burgos Marcos, M Burke, AT Burr, C Butter, JS Buytaert, J Byczynski, W Cadeddu, S Cai, H Caillet, A Calabrese, R Calderon Ramirez, S Calefice, L Cali, S Calvi, M Calvo Gomez, M Camargo Magalhaes, P Cambon Bouzas, JI Campana, P Campora Perez, DH Campoverde Quezada, AF Capelli, S Capriotti, L Caravaca-Mora, R Carbone, A Carcedo Salgado, L Cardinale, R Cardini, A Carniti, P Carus, L Casais Vidal, A Caspary, R Casse, G Cattaneo, M Cavallero, G Cavallini, V Celani, S Cesare, S Chadwick, AJ Chahrour, I Chang, H Charles, M Charpentier, Ph Chatzianagnostou, E Chefdeville, M Chen, C Chen, S Chen, Z Chernov, A Chernyshenko, S Chiotopoulos, X Chobanova, V Chrzaszcz, M Chubykin, A Chulikov, V Ciambrone, P Cid Vidal, X Ciezarek, G Cifra, P Clarke, PEL Clemencic, M Cliff, HV Closier, J Cocha Toapaxi, C Coco, V Cogan, J Cogneras, E Cojocariu, L Collaviti, S Collins, P Colombo, T Colonna, M Comerma-Montells, A Congedo, L Contu, A Cooke, N Corredoira, I Correia, A Corti, G Cottee Meldrum, J Couturier, B Craik, DC Cruz Torres, M Curras Rivera, E Currie, R Da Silva, CL Dadabaev, S Dai, L Dai, X Dall’Occo, E Dalseno, J D’Ambrosio, C Daniel, J Danilina, A d’Argent, P Darze, G Davidson, A Davies, JE De Aguiar Francisco, O De Angelis, C De Benedetti, F de Boer, J De Bruyn, K De Capua, S De Cian, M De Freitas Carneiro Da Graca, U De Lucia, E De Miranda, JM De Paula, L De Serio, M De Simone, P De Vellis, F de Vries, JA Debernardis, F Decamp, D Dedu, V Dekkers, S Del Buono, L Delaney, B Dembinski, H-P Deng, J Denysenko, V Deschamps, O Dettori, F Dey, B Di Nezza, P Diachkov, I Didenko, S Ding, S Dittmann, L Dobishuk, V Docheva, AD Dong, C Donohoe, AM Dordei, F dos Reis, AC Dowling, AD Duan, W Duda, P Dudek, MW Dufour, L Duk, V Durante, P Duras, MM Durham, JM Durmus, OD Dziurda, A Dzyuba, A Easo, S Eckstein, E Egede, U Egorychev, A Egorychev, V Eisenhardt, S Ejopu, E Eklund, L Elashri, M Ellbracht, J Ely, S Ene, A Eschle, J Esen, S Evans, T Fabiano, F Falcao, LN Fan, Y Fang, B Fantini, L Faria, M Farmer, K Fazzini, D Felkowski, L Feng, M Feo, M Fernandez Casani, A Fernandez Gomez, M Fernez, AD Ferrari, F Ferreira Rodrigues, F Ferrillo, M Ferro-Luzzi, M Filippov, S Fini, RA Fiorini, M Firlej, M Fischer, KL Fitzgerald, DS Fitzpatrick, C Fiutowski, T Fleuret, F Fontana, M Foreman, LF Forty, R Foulds-Holt, D Franco Lima, V Franco Sevilla, M Frank, M Franzoso, E Frau, G Frei, C Friday, DA Fu, J Führing, Q Fujii, Y Fulghesu, T Gabriel, E Galati, G Galati, MD Gallas Torreira, A Galli, D Gambetta, S Gandelman, M Gandini, P Ganie, B Gao, H Gao, R Gao, TQ Gao, Y Gao, Y Gao, Y Garcia Martin, LM Garcia Moreno, P García Pardiñas, J Gardner, P Garg, KG Garrido, L Gaspar, C Gavrikov, A Gerken, LL Gersabeck, E Gersabeck, M Gershon, T Ghizzo, S Ghorbanimoghaddam, Z Giambastiani, L Giasemis, FI Gibson, V Giemza, HK Gilman, AL Giovannetti, M Gioventù, A Girardey, L Giugliano, C Giza, MA Glaser, FC Gligorov, VV Göbel, C Golinka-Bezshyyko, L Golobardes, E Golubkov, D Golutvin, A Gomez Fernandez, S Gomulka, W Goncalves Abrantes, F Goncerz, M Gong, G Gooding, JA Gorelov, IV Gotti, C Govorkova, E Grabowski, JP Granado Cardoso, LA Graugés, E Graverini, E Grazette, L Graziani, G Grecu, AT Greeven, LM Grieser, NA Grillo, L Gromov, S Gu, C Guarise, M Guerry, L Guliaeva, V Günther, PA Guseinov, A-K Gushchin, E Guz, Y Gys, T Habermann, K Hadavizadeh, T Hadjivasiliou, C Haefeli, G Haen, C Hallett, G Halvorsen, MM Hamilton, PM Hammerich, J Han, Q Han, X Hansmann-Menzemer, S Hao, L Harnew, N Harris, TH Hartmann, M Hashmi, S He, J Hemmer, F Henderson, C Henderson, RDL Hennequin, AM Hennessy, K Henry, L Herd, J Herrero Gascon, P Heuel, J Hicheur, A Hijano Mendizabal, G Horswill, J Hou, R Hou, Y Howarth, N Hu, J Hu, W Hu, X Huang, W Hulsbergen, W Hunter, RJ Hushchyn, M Hutchcroft, D Idzik, M Ilin, D Ilten, P Inglessi, A Iniukhin, A Ishteev, A Ivshin, K Jacobsson, R Jage, H Jaimes Elles, SJ Jakobsen, S Jans, E Jashal, BK Jawahery, A Jevtic, V Jiang, E Jiang, X Jiang, Y Jiang, YJ John, M John Rubesh Rajan, A Johnson, D Jones, CR Jones, TP Joshi, S Jost, B Juan Castella, J Jurik, N Juszczak, I Kaminaris, D Kandybei, S Kane, M Kang, Y Kar, C Karacson, M Karpenkov, D Kauniskangas, A Kautz, JW Kazanecki, MK Keizer, F Kenzie, M Ketel, T Khanji, B Kharisova, A Kholodenko, S Khreich, G Kirn, T Kirsebom, VS Kitouni, O Klaver, S Kleijne, N Klimaszewski, K Kmiec, MR Koliiev, S Kolk, L Konoplyannikov, A Kopciewicz, P Koppenburg, P Korolev, M Kostiuk, I Kot, O Kotriakhova, S Kozachuk, A Kravchenko, P Kravchuk, L Kreps, M Krokovny, P Krupa, W Krzemien, W Kshyvanskyi, O Kubis, S Kucharczyk, M Kudryavtsev, V Kulikova, E Kupsc, A Kutsenko, B Lacarrere, D Laguarta Gonzalez, P Lai, A Lampis, A Lancierini, D Landesa Gomez, C Lane, JJ Lane, R Lanfranchi, G Langenbruch, C Langer, J Lantwin, O Latham, T Lazzari, F Lazzeroni, C Le Gac, R Lee, H Lefèvre, R Leflat, A Legotin, S Lehuraux, M Lemos Cid, E Leroy, O Lesiak, T Lesser, ED Leverington, B Li, A Li, C Li, C Li, H Li, K Li, L Li, M Li, P Li, P-R Li, Q Li, S Li, T Li, T Li, Y Li, Y Lian, Z Liang, X Libralon, S Lin, C Lin, T Lindner, R Linton, H Lisovskyi, V Litvinov, R Liu, FL Liu, G Liu, K Liu, S Liu, W Liu, Y Liu, Y Liu, YL Loachamin Ordonez, G Lobo Salvia, A Loi, A Long, T Lopes, JH Lopez Huertas, A López Soliño, S Lu, Q Lucarelli, C Lucchesi, D Lucio Martinez, M Lukashenko, V Luo, Y Lupato, A Luppi, E Lynch, K Lyu, X-R Ma, GM Maccolini, S Machefert, F Maciuc, F Mack, B Mackay, I Mackey, LM Madhan Mohan, LR Madurai, MJ Maevskiy, A Magdalinski, D Maisuzenko, D Malczewski, JJ Malde, S Malentacca, L Malinin, A Maltsev, T Manca, G Mancinelli, G Mancuso, C Manera Escalero, R Manganella, FM Manuzzi, D Marangotto, D Marchand, JF Marchevski, R Marconi, U Mariani, E Mariani, S Marin Benito, C Marks, J Marshall, AM Martel, L Martelli, G Martellotti, G Martinazzoli, L Martinelli, M Martinez Gomez, D Martinez Santos, D Martinez Vidal, F Martorell i Granollers, A Massafferri, A Matev, R Mathad, A Matiunin, V Matteuzzi, C Mattioli, KR Mauri, A Maurice, E Mauricio, J Mayencourt, P Mazorra de Cos, J Mazurek, M McCann, M McGrath, TH McHugh, NT McNab, A McNulty, R Meadows, B Meier, G Melnychuk, D Meng, FM Merk, M Merli, A Meyer Garcia, L Miao, D Miao, H Mikhasenko, M Milanes, DA Minotti, A Minucci, E Miralles, T Mitreska, B Mitzel, DS Modak, A Moeser, L Mohammed, RA Moise, RD Mokhnenko, S Molina Cardenas, EF Mombächer, T Monk, M Monteil, S Morcillo Gomez, A Morello, G Morello, MJ Morgenthaler, MP Moron, J Morren, W Morris, AB Morris, AG Mountain, R Mu, H Mu, ZM Muhammad, E Muheim, F Mulder, M Müller, K Muñoz-Rojas, F Murta, R Naik, P Nakada, T Nandakumar, R Nanut, T Nasteva, I Neri, N Neubert, S Neufeld, N Neustroev, P Nicolini, J Nicotra, D Niel, EM Nikitin, N Niu, Q Nogarolli, P Nogga, P Normand, C Novoa Fernandez, J Nowak, G Nunez, C Nur, HN Oblakowska-Mucha, A Obraztsov, V Oeser, T Okamura, S Okhotnikov, A Okhrimenko, O Oldeman, R Oliva, F Olocco, M Onderwater, CJG O’Neil, RH Osthues, D Otalora Goicochea, JM Owen, P Oyanguren, A Ozcelik, O Paciolla, F Padee, A Padeken, KO Pagare, B Pais, PR Pajero, T Palano, A Palutan, M Pan, X Panshin, G Paolucci, L Papanestis, A Pappagallo, M Pappalardo, LL Pappenheimer, C Parkes, C Parmar, D Passalacqua, B Passaleva, G Passaro, D Pastore, A Patel, M Patoc, J Patrignani, C Paul, A Pawley, CJ Pellegrino, A Peng, J Pepe Altarelli, M Perazzini, S Pereima, D Pereira Da Costa, H Pereiro Castro, A Perret, P Perrevoort, A Perro, A Peters, MJ Petridis, K Petrolini, A Pfaller, JP Pham, H Pica, L Piccini, M Piccolo, L Pietrzyk, B Pietrzyk, G Pilato, RN Pinci, D Pisani, F Pizzichemi, M Placinta, VM Plo Casasus, M Poeschl, T Polci, F Poli Lener, M Poluektov, A Polukhina, N Polyakov, I Polycarpo, E Ponce, S Popov, D Poslavskii, S Prasanth, K Prouve, C Provenzano, D Pugatch, V Punzi, G Qasim, S Qian, QQ Qian, W Qin, N Qu, S Quagliani, R Rabadan Trejo, RI Rademacker, JH Rama, M Ramírez García, M Ramos De Oliveira, V Ramos Pernas, M Rangel, MS Ratnikov, F Raven, G Rebollo De Miguel, M Redi, F Reich, J Reiss, F Ren, Z Resmi, PK Ribalda Galvez, M Ribatti, R Ricart, G Riccardi, D Ricciardi, S Richardson, K Richardson-Slipper, M Rinnert, K Robbe, P Robertson, G Rodrigues, E Rodriguez Alvarez, A Rodriguez Fernandez, E Rodriguez Lopez, JA Rodriguez Rodriguez, E Roensch, J Rogachev, A Rogovskiy, A Rolf, DL Roloff, P Romanovskiy, V Romero Vidal, A Romolini, G Ronchetti, F Rong, T Rotondo, M Roy, SR Rudolph, MS Ruiz Diaz, M Ruiz Fernandez, RA Ruiz Vidal, J Ryzka, J Saavedra-Arias, JJ Saborido Silva, JJ Sadek, R Sagidova, N Sahoo, D Sahoo, N Saitta, B Salomoni, M Sanderswood, I Santacesaria, R Santamarina Rios, C Santimaria, M Santoro, L Santovetti, E Saputi, A Saranin, D Sarnatskiy, A Sarpis, G Sarpis, M Satriano, C Satta, A Saur, M Savrina, D Sazak, H Sborzacchi, F Scarabotto, A Schael, S Scherl, S Schiller, M Schindler, H Schmelling, M Schmidt, B Schmitt, S Schmitz, H Schneider, O Schopper, A Schulte, N Schulte, S Schune, MH Schwering, G Sciascia, B Sciuccati, A Segal, I Sellam, S Semennikov, A Senger, T Senghi Soares, M Sergi, A Serra, N Sestini, L Seuthe, A Shang, Y Shangase, DM Shapkin, M Sharma, RS Shchemerov, I Shchutska, L Shears, T Shekhtman, L Shen, Z Sheng, S Shevchenko, V Shi, B Shi, Q Shimizu, Y Shmanin, E Shorkin, R Shupperd, JD Silva Coutinho, R Simi, G Simone, S Singha, M Skidmore, N Skwarnicki, T Slater, MW Smallwood, JC Smith, E Smith, K Smith, M Snoch, A Soares Lavra, L Sokoloff, MD Soler, FJP Solomin, A Solovev, A Solovyev, I Sommerfeld, NS Song, R Song, Y Song, Y Song, YS Souza De Almeida, FL Souza De Paula, B Spadaro Norella, E Spedicato, E Speer, JG Spiridenkov, E Spradlin, P Sriskaran, V Stagni, F Stahl, M Stahl, S Stanislaus, S Stefaniak, M Stein, EN Steinkamp, O Stenyakin, O Stevens, H Strekalina, D Su, Y Suljik, F Sun, J Sun, L Sundfeld, D Sutcliffe, W Swientek, K Swystun, F Szabelski, A Szumlak, T Tan, Y Tang, Y Tat, MD Terentev, A Terzuoli, F Teubert, F Thomas, E Thompson, DJD Tilquin, H Tisserand, V T’Jampens, S Tobin, M Tomassetti, L Tonani, G Tong, X Tork, T Torres Machado, D Toscano, L Tou, DY Trippl, C Tuci, G Tuning, N Uecker, LH Ukleja, A Unverzagt, DJ Upadhyay, A Urbach, B Usachov, A Ustyuzhanin, A Uwer, U Vagnoni, V Valcarce Cadenas, V Valenti, G Valls Canudas, N van Eldik, J Van Hecke, H van Herwijnen, E Van Hulse, CB Van Laak, R van Veghel, M Vasquez, G Vazquez Gomez, R Vazquez Regueiro, P Vázquez Sierra, C Vecchi, S Velthuis, JJ Veltri, M Venkateswaran, A Verdoglia, M Vesterinen, M Vico Benet, D Vidrier Villalba, P Vieites Diaz, M Vilasis-Cardona, X Vilella Figueras, E Villa, A Vincent, P Vivacqua, B Volle, FC vom Bruch, D Voropaev, N Vos, K Vrahas, C Wagner, J Walsh, J Walton, EJ Wan, G Wang, C Wang, G Wang, H Wang, J Wang, J Wang, J Wang, J Wang, M Wang, NW Wang, R Wang, X Wang, X Wang, XW Wang, Y Wang, YW Wang, Z Wang, Z Wang, Z Ward, JA Waterlaat, M Watson, NK Websdale, D Wei, Y Wendel, J Westhenry, BDC White, C Whitehead, M Whiter, E Wiederhold, AR Wiedner, D Wilkinson, G Wilkinson, MK Williams, M Williams, MJ Williams, MRJ Williams, R Williams, Z Wilson, FF Winn, M Wislicki, W Witek, M Witola, L Wormser, G Wotton, SA Wu, H Wu, J Wu, X Wu, Y Wu, Z Wyllie, K Xian, S Xiang, Z Xie, Y Xing, TX Xu, A Xu, L Xu, L Xu, M Xu, Z Xu, Z Xu, Z Yang, K Yang, S Yang, X Yang, Y Yang, Z Yeroshenko, V Yeung, H Yin, H Yin, X Yu, CY Yu, J Yuan, X Yuan, Y Zaffaroni, E Zavertyaev, M Zdybal, M Zenesini, F Zeng, C Zeng, M Zhang, C Zhang, D Zhang, J Zhang, L Zhang, S Zhang, S Zhang, Y Zhang, YZ Zhang, Z Zhao, Y Zhelezov, A Zheng, SZ Zheng, XZ Zheng, Y Zhou, T Zhou, X Zhou, Y Zhovkovska, V Zhu, LZ Zhu, X Zhu, X Zhukov, V Zhuo, J Zou, Q Zuliani, D Zunica, G https://doi.org/10.1007/jhep10(2025)050 2025-10-07 Springer Nature 2025-10-13

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Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analysing the different effects on feeding behaviour of peptide YY3-36 (PYY3-36), lithium chloride, glucagon-like peptide 1 (GLP-1), and leptin shows the precise behavioural changes caused by each anorectic agent. Our analysis demonstrates that the changes in feeding behaviour evoked by the anorectic agents investigated do not mimic the behaviour of well-fed animals and that the intermeal interval is influenced by fullness. We show how robust homeostatic control of feeding thwarts attempts to reduce food intake and how this might be overcome. In silico experiments suggest that introducing a minimum intermeal interval or modulating upper gut emptying can be as effective as anorectic drug administration. https://www.repository.cam.ac.uk/handle/1810/299551 eng https://doi.org/10.17863/CAM.46623 https://www.repository.cam.ac.uk/bitstreams/7d65a534-a41f-4c8c-aac1-8d1f079e6543/download https://www.repository.cam.ac.uk/bitstreams/5029e213-fdc0-4206-b716-c0f7ee3d15e6/download https://www.repository.cam.ac.uk/bitstreams/b9c90379-f8cf-4487-89f9-db249d964cbb/download https://www.repository.cam.ac.uk/bitstreams/73c5f7b9-bbed-4ed8-b282-525d7f7720a9/download 1544-9173 Research Article Research and analysis methods Biology and life sciences Medicine and health sciences Social sciences Physical sciences The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents http://purl.org/coar/resource_type/c_6501 2019-11-01 https://orcid.org/0000-0003-4208-6888 McGrath, Thomas M. Spreckley, Eleanor Rodriguez, Aina Fernandez Viscomi, Carlo Alamshah, Amin Akalestou, Elina https://orcid.org/0000-0002-3417-0310 Murphy, Kevin G. https://orcid.org/0000-0002-4083-972X Jones, Nick S. https://doi.org/10.1371/journal.pbio.3000482 BB/J014575/1 EP/N014529/1 NC/K500379/1 BB/I001816/1 18/0005886 2019-12-05 2019-12-06

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Too little text remains to identify. http://www.dspace.cam.ac.uk/handle/1810/235683 jrb https://www.repository.cam.ac.uk/bitstreams/24aa03c3-04e5-459f-8a5b-872b77d56e1f/download https://www.repository.cam.ac.uk/bitstreams/3210ddfb-0246-4628-9fd9-2d914a2b42b6/download https://www.repository.cam.ac.uk/bitstreams/3d7456cf-b5dd-485c-9a26-825358db4a6d/download https://www.repository.cam.ac.uk/bitstreams/63c3cb64-868e-47f0-8bd0-447551ed3d1b/download https://www.repository.cam.ac.uk/bitstreams/a48065d6-b2a5-4d4d-bc5e-bcf0ec5e22ae/download https://www.repository.cam.ac.uk/bitstreams/d4fe0b4c-c6d3-4e69-8190-802d721058db/download Genizah MS T-S AS 161.71 http://purl.org/coar/resource_type/c_1843 Unknown 2011-02-25 Taylor-Schechter Genizah Research Unit 2011-02-25

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To deploy effective communication systems in vehicle cavities, it is critical to understand the time variation of the in-vehicle channel. Initially, rapid channel variation is addressed, which is characterized in the frequency domain as a Doppler spread. It is then shown that, for typical Doppler spreads, the in-vehicle channel is underspread, and therefore, the information capacity approaches the capacity achieved with perfect receiver channel state information in the infinite bandwidth limit. Measurements are performed for a number of channel variation scenarios (e.g., absorptive motion, reflective motion, one antenna moving, and both antennas moving) at a number of carrier frequencies and for a number of cavity loading scenarios. It is found that the Doppler spread increases with carrier frequency; however, the type of channel variation and loading appear to have little effect. Channel variation over a longer time period is also measured to characterize the slower channel variation. Channel variation is a function of the cavity occupant motion, which is difficult to model theoretically; therefore, an empirical model for the slow channel variation is proposed, which leads to an improved estimate of the channel state. https://www.repository.cam.ac.uk/handle/1810/245447 eng https://www.repository.cam.ac.uk/bitstreams/837c6983-ad11-4689-8069-60d5d4633174/download 0090-6778 4613 Theory Of Computation 46 Information and Computing Sciences 4006 Communications Engineering 40 Engineering Characterizing the Spectral Properties and Time Variation of the In-Vehicle Wireless Communication Channel http://purl.org/coar/resource_type/c_6501 https://orcid.org/0000-0003-0948-5721 Herbert, Steven https://orcid.org/0000-0001-7927-5565 Wassell, Ian Loh, Tian-Hong Rigelsford, Jonathan https://doi.org/10.1109/tcomm.2014.2328635 2014-07 Institute of Electrical and Electronics Engineers (IEEE) 2014-07-10

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Logging and habitat fragmentation impact tropical forest ecosystems in numerous ways, perhaps the most striking of which is by altering the temperature, humidity, and light environment of the forest—its microclimate. Because local-scale microclimatic conditions directly influence the physiology, demography and behavior of most species, many of the impacts of land-use intensification on the biodiversity and ecosystem functioning of tropical forests have been attributed to changes in microclimate. However, the actual pathways through which altered microclimatic conditions reshape the ecology of these human-modified ecosystems remain largely unexplored. To bridge this knowledge gap, here we outline an agenda for future microclimate research in human-modified tropical ecosystems. We focus specifically on three main themes: the role of microclimate in shaping (i) species distributions, (ii) species interactions, and (iii) ecosystem functioning in tropical forests. In doing so we aim to highlight how a renewed focus on microclimate can help us not only better understand the ecology of human-modified tropical ecosystems, but also guide efforts to manage and protect them. https://www.repository.cam.ac.uk/handle/1810/301499 eng https://doi.org/10.17863/CAM.48571 https://www.repository.cam.ac.uk/bitstreams/d5bc382d-268c-4c85-90f2-4de78956a37c/download https://www.repository.cam.ac.uk/bitstreams/9c965b79-6ff2-4770-8866-db4bbf33350e/download https://www.repository.cam.ac.uk/bitstreams/36e5dfb3-7cc2-4e0d-931a-d81ca7060bc2/download 2624-893X 30 Agricultural, Veterinary and Food Sciences 3007 Forestry Sciences 15 Life on Land A Research Agenda for Microclimate Ecology in Human-Modified Tropical Forests http://purl.org/coar/resource_type/c_1843 2019-12-23 Jucker, Tommaso Jackson, Tobias D Zellweger, Florian Swinfield, Tom Gregory, Nichar Williamson, Joseph Slade, Eleanor M Phillips, Josie W Bittencourt, Paulo RL Blonder, Benjamin Boyle, Michael JW Ellwood, MD Farnon Hemprich-Bennett, David Lewis, Owen T Matula, Radim Senior, Rebecca A Shenkin, Alexander Svátek, Martin Coomes, David A https://doi.org/10.3389/ffgc.2019.00092 NE/K016253/1 NE/K016377/1 NE/S010750/1 2020-01-17 Frontiers 2020-01-31

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Text and translation of Nehemiah 13:9–11 and 13:12–14 http://www.dspace.cam.ac.uk/handle/1810/227833 heb jrb https://www.repository.cam.ac.uk/bitstreams/16f22147-6ea7-471e-8aa5-9efe086669ae/download https://www.repository.cam.ac.uk/bitstreams/18064aba-9dc0-4f56-9195-e00d3190f712/download https://www.repository.cam.ac.uk/bitstreams/3a427c3f-e9d9-42a8-889d-279d5232fee1/download https://www.repository.cam.ac.uk/bitstreams/5082fa8a-686f-42d4-8f7e-d969435f13fd/download https://www.repository.cam.ac.uk/bitstreams/b48d113e-c7d8-44ae-a925-6e9679ca569a/download https://www.repository.cam.ac.uk/bitstreams/c66cdaff-afbf-45aa-8287-502503dc6bb2/download https://www.repository.cam.ac.uk/bitstreams/c81f17b6-690e-4cf1-b429-dbdfb195b9df/download https://www.repository.cam.ac.uk/bitstreams/e7246c01-1337-4568-b9e1-23da17c75148/download Genizah MS T-S AS 71.173 http://purl.org/coar/resource_type/c_1843 Unknown 2010-12-07 Taylor-Schechter Genizah Research Unit 2010-12-07

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Legal document; mentions someone's death. http://www.dspace.cam.ac.uk/handle/1810/234512 jrb https://www.repository.cam.ac.uk/bitstreams/10f88312-e0b0-46e8-8c65-3c76a303d4f5/download https://www.repository.cam.ac.uk/bitstreams/41ac08eb-459e-4d8a-b14f-e6fd2bb19223/download https://www.repository.cam.ac.uk/bitstreams/4cdfc789-49fb-4c1e-b665-8dfaf68a3613/download https://www.repository.cam.ac.uk/bitstreams/abe4251e-edf8-44fa-a1f7-d17962bac697/download https://www.repository.cam.ac.uk/bitstreams/f293bfd1-08ed-4186-920c-c5c41b626625/download https://www.repository.cam.ac.uk/bitstreams/fdad316e-ff44-474e-9609-8746d6d526e6/download Genizah MS T-S AS 153.394 http://purl.org/coar/resource_type/c_1843 Unknown 2011-02-25 Taylor-Schechter Genizah Research Unit 2011-02-25

oai:www.repository.cam.ac.uk:1810/3260782025-12-19T17:57:59Zcom_1810_229649com_1810_751com_1810_256067col_1810_368714

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic will be remembered as one of the defining events of the 21st century. The rapid global outbreak has had significant impacts on human society and is already responsible for millions of deaths. Understanding and tackling the impact of the virus has required a worldwide mobilisation and coordination of scientific research. The COVID-19 Data Portal (https://www.covid19dataportal.org/) was first released as part of the European COVID-19 Data Platform, on April 20th 2020 to facilitate rapid and open data sharing and analysis, to accelerate global SARS-CoV-2 and COVID-19 research. The COVID-19 Data Portal has fortnightly feature releases to continue to add new data types, search options, visualisations and improvements based on user feedback and research. The open datasets and intuitive suite of search, identification and download services, represent a truly FAIR (Findable, Accessible, Interoperable and Reusable) resource that enables researchers to easily identify and quickly obtain the key datasets needed for their COVID-19 research. https://www.repository.cam.ac.uk/handle/1810/326078 eng https://doi.org/10.17863/CAM.73536 https://www.repository.cam.ac.uk/bitstreams/ddfa6c17-7b5d-4ee5-9276-3f193031e82d/download 0305-1048 Biomedical Research COVID-19 Databases, Bibliographic Databases, Factual Datasets as Topic Disease Outbreaks Humans Information Dissemination Open Access Publishing Pandemics SARS-CoV-2 Time Factors Viral Proteins The COVID-19 Data Portal: accelerating SARS-CoV-2 and COVID-19 research through rapid open access data sharing. http://purl.org/coar/resource_type/c_6501 2021-05-01 https://orcid.org/0000-0002-4007-2899 Harrison, Peter W https://orcid.org/0000-0003-1256-7306 Lopez, Rodrigo Rahman, Nadim Allen, Stefan Gutnick Aslam, Raheela Buso, Nicola Cummins, Carla Fathy, Yasmin Felix, Eloy https://orcid.org/0000-0002-8211-7581 Glont, Mihai Jayathilaka, Suran Kadam, Sandeep Kumar, Manish Lauer, Katharina B Malhotra, Geetika Mosaku, Abayomi Edbali, Ossama Park, Young Mi Parton, Andrew Pearce, Matt Estrada Pena, Jose Francisco Rossetto, Joseph Russell, Craig Selvakumar, Sandeep Sitjà, Xènia Pérez Sokolov, Alexey Thorne, Ross Ventouratou, Marianna Walter, Peter Yordanova, Galabina https://orcid.org/0000-0001-5310-8830 Zadissa, Amonida https://orcid.org/0000-0001-7954-7057 Cochrane, Guy https://orcid.org/0000-0003-4155-5910 Blomberg, Niklas Apweiler, Rolf https://doi.org/10.1093/nar/gkab417 871075 824087 2021-07-02 Oxford University Press (OUP) 2021-07-29

oai:www.repository.cam.ac.uk:1810/3469652025-12-19T17:58:00Zcom_1810_751com_1810_256067col_1810_294790

Design of the next-generation of therapeutics, biosensors, and molecular tools for basic research requires that we bring protein activity under control. Each protein has unique properties, and therefore, it is critical to tailor the current techniques to develop new regulatory methods and regulate new proteins of interest (POIs). This perspective gives an overview of the widely used stimuli and synthetic and natural methods for conditional regulation of proteins. https://www.repository.cam.ac.uk/handle/1810/346965 eng https://doi.org/10.17863/CAM.94381 https://www.repository.cam.ac.uk/bitstreams/d3148726-9b65-42ff-907b-5f59905ee50a/download https://www.repository.cam.ac.uk/bitstreams/902cfa16-0324-4a93-a099-68c7614c9f61/download 2691-3704 Proteins and peptides conditional regulation covalent protein regulation noncovalent protein regulation conformational protein regulation protein compartmentalization Strategies for Conditional Regulation of Proteins. http://purl.org/coar/resource_type/c_6501 2023-01-10 Nadendla, Karthik Simpson, Grant G Becher, Julie https://orcid.org/0000-0003-4561-1828 Journeaux, Toby Cabeza-Cabrerizo, Mar https://orcid.org/0000-0001-6594-8917 Bernardes, Gonçalo JL https://doi.org/10.1021/jacsau.2c00654 676832 2023-02-27 American Chemical Society (ACS) 2023-02-28

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This speculative essay suggests that instead of arguing for the Middle Ages as essential, instead of arguing for the Middle Ages’ modernity, medievalists ought to embrace the contingency of the Middle Ages. This means thinking the Middle Ages as neither a disposable patch of darkness nor an essential stage on the way to modernity. Particularly in relation to disability studies, critical race studies, queer studies, trans studies, and other social justice fields, it is precisely because the Middle Ages open a space of contingency that they can enable us to think modernity otherwise. https://www.repository.cam.ac.uk/handle/1810/376204 eng https://doi.org/10.17863/CAM.113534 https://www.repository.cam.ac.uk/bitstreams/603aae7e-535d-40ff-93e1-c572824e8958/download 0038-7134 The Contingent Middle Ages http://purl.org/coar/resource_type/c_6501 2024-11-13 Charmaille, François E https://doi.org/10.1086/737819 2026-01-01 University of Chicago Press 2024-11-15

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In this study, a three-layered multicenter ONIOM approach is implemented to characterize the naive folding pathway of bovine pancreatic trypsin inhibitor (BPTI). Each layer represents a distinct level of theory, where the initial layer, encompassing the entire protein, is modeled by a general all-atom force-field GFN-FF. An intermediate electronic structure layer consisting of three multicenter fragments is introduced with the state-of-the-art semiempirical tight-binding method GFN2-xTB. Higher accuracy, specifically addressing the breaking and formation of the three disulfide bonds, is achieved at the innermost layer using the composite DFT method r2SCAN-3c. Our analysis sheds light on the structural stability of BPTI, particularly the significance of interlinking disulfide bonds. The accuracy and efficiency of the multicenter QM/SQM/MM approach are benchmarked using the oxidative formation of cystine. For the folding pathway of BPTI, relative stabilities are investigated through the calculation of free energy contributions for selected intermediates, focusing on the impact of the disulfide bond. Our results highlight the intricate trade-off between accuracy and computational cost, demonstrating that the multicenter ONIOM approach provides a well-balanced and comprehensive solution to describe electronic structure effects in biomolecular systems. We conclude that multiscale energy landscape exploration provides a robust methodology for the study of intriguing biological targets. https://www.repository.cam.ac.uk/handle/1810/366729 eng https://www.repository.cam.ac.uk/bitstreams/c319b2cb-92ee-4ad7-86e3-26894faf3d93/download https://www.repository.cam.ac.uk/bitstreams/b8219489-ca51-4433-82cb-1d924dd9caa1/download 1520-6106 Animals Cattle Aprotinin Cystine Disulfides Protein Folding Proteins Multilevel Framework for Analysis of Protein Folding Involving Disulfide Bond Formation. http://purl.org/coar/resource_type/c_6501 2024-03-08 https://orcid.org/0000-0002-7751-980X Wesołowski, Patryk A https://orcid.org/0000-0002-3555-6645 Wales, David J https://orcid.org/0000-0002-8495-9504 Pracht, Philipp https://doi.org/10.1021/acs.jpcb.4c00104 EP/W524633/1 2024-04-04 American Chemical Society (ACS) 2024-04-05

oai:www.repository.cam.ac.uk:1810/2913842025-12-19T17:58:03Zcom_1810_229649com_1810_751com_1810_256067col_1810_368714

A high-quality reference genome is a fundamental resource for functional genetics, comparative genomics, and population genomics, and is increasingly important for conservation biology. PacBio Single Molecule, Real-Time (SMRT) sequencing generates long reads with uniform coverage and high consensus accuracy, making it a powerful technology for de novo genome assembly. Improvements in throughput and concomitant reductions in cost have made PacBio an attractive core technology for many large genome initiatives, however, relatively high DNA input requirements (~5 µg for standard library protocol) have placed PacBio out of reach for many projects on small organisms that have lower DNA content, or on projects with limited input DNA for other reasons. Here we present a high-quality de novo genome assembly from a single Anopheles coluzzii mosquito. A modified SMRTbell library construction protocol without DNA shearing and size selection was used to generate a SMRTbell library from just 100 ng of starting genomic DNA. The sample was run on the Sequel System with chemistry 3.0 and software v6.0, generating, on average, 25 Gb of sequence per SMRT Cell with 20 h movies, followed by diploid de novo genome assembly with FALCON-Unzip. The resulting curated assembly had high contiguity (contig N50 3.5 Mb) and completeness (more than 98% of conserved genes were present and full-length). In addition, this single-insect assembly now places 667 (>90%) of formerly unplaced genes into their appropriate chromosomal contexts in the AgamP4 PEST reference. We were also able to resolve maternal and paternal haplotypes for over 1/3 of the genome. By sequencing and assembling material from a single diploid individual, only two haplotypes were present, simplifying the assembly process compared to samples from multiple pooled individuals. The method presented here can be applied to samples with starting DNA amounts as low as 100 ng per 1 Gb genome size. This new low-input approach puts PacBio-based assemblies in reach for small highly heterozygous organisms that comprise much of the diversity of life. https://www.repository.cam.ac.uk/handle/1810/291384 eng https://doi.org/10.17863/CAM.38556 https://www.repository.cam.ac.uk/bitstreams/3a9739b4-54a1-4956-980a-cdd8a8e5da33/download 2073-4425 de novo genome assembly long-read SMRT sequencing low-input DNA mosquito Animals Anopheles Contig Mapping Genome, Insect Ploidies Polymorphism, Genetic Sequence Analysis, DNA A High-Quality De novo Genome Assembly from a Single Mosquito Using PacBio Sequencing. http://purl.org/coar/resource_type/c_6501 2019-01-15 https://orcid.org/0000-0002-4900-0189 Kingan, Sarah B https://orcid.org/0000-0002-9649-525X Heaton, Haynes Cudini, Juliana Lambert, Christine C Baybayan, Primo Galvin, Brendan D https://orcid.org/0000-0002-9130-1006 Durbin, Richard https://orcid.org/0000-0003-3047-4250 Korlach, Jonas https://orcid.org/0000-0002-3006-2080 Lawniczak, Mara KN https://doi.org/10.3390/genes10010062 2019-01-18 MDPI 2019-04-09

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This article is a reply to critics who contributed to a roundtable on my book, Hegel's World Revolutions. It offers a series of clarifications with a restatement of some core positions, defending historically informed interpretation, and then covering the reception of his work, his views on contemporary politics, the nature of his metaphysics, and the grounds for criticising his claims. https://www.repository.cam.ac.uk/handle/1810/374455 eng https://doi.org/10.17863/CAM.112521 https://www.repository.cam.ac.uk/bitstreams/45c97e79-acaa-41d2-a4ed-28e625fa05a8/download 0191-6599 5003 Philosophy 50 Philosophy and Religious Studies 5002 History and Philosophy Of Specific Fields Reflections on Hegel’s World Revolutions: a reply to critics http://purl.org/coar/resource_type/c_6501 https://orcid.org/0000-0003-4355-7434 Bourke, Richard https://doi.org/10.1080/01916599.2024.2408892 2025-02-17 Taylor & Francis 2024-10-04

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Epstein-Barr virus (EBV) is a B cell transforming virus that causes B cell malignancies under conditions of immune suppression. EBV orchestrates B cell transformation through its latent membrane proteins (LMPs) and Epstein-Barr nuclear antigens (EBNAs). We here identify secondary mutations in mouse B cell lymphomas induced by LMP1, to predict and identify key functions of other EBV genes during transformation. We find aberrant activation of early B cell factor 1 (EBF1) to promote transformation of LMP1-expressing B cells by inhibiting their differentiation to plasma cells. EBV EBNA3A phenocopies EBF1 activities in LMP1-expressing B cells, promoting transformation while inhibiting differentiation. In cells expressing LMP1 together with LMP2A, EBNA3A only promotes lymphomagenesis when the EBNA2 target Myc is also overexpressed. Collectively, our data support a model where proproliferative activities of LMP1, LMP2A, and EBNA2 in combination with EBNA3A-mediated inhibition of terminal plasma cell differentiation critically control EBV-mediated B cell lymphomagenesis. https://www.repository.cam.ac.uk/handle/1810/306825 eng https://doi.org/10.17863/CAM.53916 https://www.repository.cam.ac.uk/bitstreams/6f5dc402-a9df-4afd-a70a-b3a924c0555e/download 0027-8424 B cell lymphomagenesis EBNA Epstein-Barr virus LMP1 plasma cell differentiation Animals Cell Differentiation Cell Line, Tumor Cell Transformation, Viral DNA-Binding Proteins Disease Models, Animal Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Fibroblasts Herpesvirus 4, Human Humans Lymphoma, B-Cell Mice Mice, Knockout Plasma Cells Primary Cell Culture Trans-Activators Viral Matrix Proteins Viral Proteins Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis. http://purl.org/coar/resource_type/c_6501 2020-04-22 https://orcid.org/0000-0003-2899-0256 Sommermann, Thomas Yasuda, Tomoharu https://orcid.org/0000-0003-3980-6469 Ronen, Jonathan Wirtz, Tristan https://orcid.org/0000-0003-2079-842X Weber, Timm Sack, Ulrike Caeser, Rebecca Zhang, Jingwei Li, Xun Chu, Van Trung Jauch, Anna Unger, Kristian https://orcid.org/0000-0001-6225-2033 Hodson, Daniel J Akalin, Altuna Rajewsky, Klaus https://doi.org/10.1073/pnas.1921139117 MR/M008584/1 MC_PC_12009 MC_PC_17230 2020-06-23 Proceedings of the National Academy of Sciences 2020-06-15

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<jats:p>The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) play a central role in regulating cell signalling pathways and, as such, have become therapeutic targets for diseases such as cancer, neurodegeneration and immunological disorders....</jats:p> https://www.repository.cam.ac.uk/handle/1810/348642 eng https://doi.org/10.17863/CAM.96069 https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/7a802728-3d18-4794-9de0-e9855c59de42/download 2632-8682 3404 Medicinal and Biomolecular Chemistry 34 Chemical Sciences Cancer Neurodegenerative 5.1 Pharmaceuticals 1 Underpinning research 1.1 Normal biological development and functioning 5 Development of treatments and therapeutic interventions Cancer Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor http://purl.org/coar/resource_type/c_6501 2023-04-03 Willems, Henriëtte MG Edwards, Simon Boffey, Helen K Chawner, Stephen J Green, Christopher Romero, Tamara Winpenny, David Skidmore, John Clarke, Jonathan H Andrews, Stephen P https://doi.org/10.1039/d3md00039g ARUK-2015DDI-CAM 2023-04-13 Royal Society of Chemistry (RSC) 2023-04-13

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http://www.dspace.cam.ac.uk/handle/1810/214263 eng https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/40c85532-02b6-45d7-b4ff-108b5e1e6cc8/download https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/39b63a75-ff34-4781-9ec3-df33f0c6ba2c/download https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/50f51514-896a-4201-8f60-f01b615e4975/download https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/f3377881-d6e7-4026-8ac0-a2b901c4438a/download Trinity College, MS O.9.38, 86r http://purl.org/coar/resource_type/c_c513 Les Goodey, Cambridge University Library 2009-02-09 University of Cambridge, Faculty of English, Scriptorium: Medieval and Early Modern Manuscripts Online 2009-02-09

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https://www.repository.cam.ac.uk/handle/1810/334547 eng https://doi.org/10.17863/CAM.81966 https://www.repository.cam.ac.uk/bitstreams/97e5ae51-60a9-4d2d-9d25-78dd5fbba180/download https://www.repository.cam.ac.uk/bitstreams/245f1a8b-b0b8-4a17-be91-925e5f85320b/download Correction Correction to: Assessing and disclosing test results for ‘mild cognitive impairment’: the perspective of old age psychiatrists in Scotland http://purl.org/coar/resource_type/c_1843 Saunders, Stina Ritchie, Craig W. Russ, Tom C. Muniz-Terrera, Graciela Milne, Richard https://doi.org/10.1186/s12877-022-02770-9 2022-02-28 BioMed Central 2022-03-01

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As if learning a second language (L2) was not challenging enough, languages continue to innovate and introduce new words. One source of lexical innovation can be the use of existing nouns as novel verbs (e.g., ‘to porch the newspaper’), which are termed denominal verbs. In a psycholinguistic study, we investigate whether L2 English speakers (N = 41) show lower acceptability judgments and higher processing effort when reading such novel denominal verbs, and whether this is influenced by their L2 proficiency or the diversity of their language experience. The results suggest that the L2 speakers are sensitive to the novel verbs, showing both reading time and judgment effects. No effects of language experience were attested, but the more proficient the speakers were, the more sensitivity they showed to the novel verbs in their judgments. This suggests that even relatively proficient L2 English speakers are still developing their flexible use of the L2, particularly when it comes to lexical innovation. https://www.repository.cam.ac.uk/handle/1810/388732 eng https://doi.org/10.17863/CAM.120950 https://www.repository.cam.ac.uk/bitstreams/fe576594-93cb-409f-86b2-bc4add2c8afe/download 2399-9101 4703 Language Studies 4704 Linguistics 5202 Biological Psychology 5204 Cognitive and Computational Psychology 47 Language, Communication and Culture 52 Psychology Basic Behavioral and Social Science Behavioral and Social Science 4 Quality Education L2 English Speakers’ Ability to Process Novel Denominal Verbs: The Role of Proficiency and Language Experience http://purl.org/coar/resource_type/c_6501 2025-07-02 https://orcid.org/0000-0003-2811-5419 Vogelzang, Margreet https://orcid.org/0000-0003-0820-8968 Carston, Robyn https://orcid.org/0000-0001-6015-7526 Tsimpli, Ianthi https://doi.org/10.22599/jesla.120 2025 White Rose University Press 2025-08-29

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INTRODUCTION: Claes-Jensen syndrome is a rare X-linked syndromic neurodevelopmental disorder by pathogenic variants in lysine specific demethylase 5C (KDM5C), a lysine-specific histone demethylase. METHODS: In this study, clinical evaluations were conducted in affected individuals and carrier females. X-chromosome inactivation (XCI) assays were performed to assess genotype-phenotype correlations. Functional studies evaluated variant effects on RNA transcription, protein expression, and stability. Zebrafish models were used for in vivo validation. RNA sequencing with KEGG and GO analyses identified dysregulated genes and pathways, further confirmed in zebrafish. RESULTS: Two novel KDM5C variants NM_004187.5:c.3019del and NM_004187.5:c.782-2A>T were identified in unrelated families with X-linked ID. Affected males presented with short stature, microcephaly, language delay, and intellectual disability, while carrier females showed milder features including learning difficulties and short stature. Skewed XCI in some carriers suggested a role in phenotypic variability. Both variants impair RNA transcription, protein expression and stability. Zebrafish models recapitulated neurodevelopmental and behavioral abnormalities. Transcriptomic analyses revealed disrupted antiviral and interferon-related signaling, implicating aberrant immune activation. Pharmacologic inhibition of the Toll-like receptor pathway ameliorated mutant phenotypes, highlighting neuroinflammation as a potential therapeutic target for KDM5C-related disorders. CONCLUSION: These findings expand the mutational spectrum of KDM5C-associated ID and uncover a novel pathogenic mechanism between KDM5C dysfunction, protein instability, and dysregulated inflammatory signaling. https://www.repository.cam.ac.uk/handle/1810/398973 eng https://www.repository.cam.ac.uk/bitstreams/09bc38f6-50c9-4a94-b19a-a6e103110056/download https://www.repository.cam.ac.uk/bitstreams/073a2f17-20be-4bce-b4af-45bd341b14ee/download https://www.repository.cam.ac.uk/bitstreams/245bd5cb-af3d-40a6-9109-d7c8977ab96e/download 1662-5099 Claes-Jensen syndrome KDM5C X-linked intellectual disability neuroimmunity neuroinflammation novel variants Emerging role of KDM5C in X-linked intellectual disability based on human genetic data and zebrafish models. http://purl.org/coar/resource_type/c_6501 2026-01-08 Liao, Baoqiong Chen, Meihuan Huang, Yun Shuai, Mei Xu, Liangpu He, Shuwen Huang, Hailong https://doi.org/10.3389/fnmol.2026.1750311 2026 Frontiers 2026-02-24 rioxx////100