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The structural and functional characterisation of the PLAT domain of polycystin-1 https://doi.org/10.17863/CAM.123440 Eustace, Hannah Sandford, Richard Autosomal dominant polycystic kidney disease (ADPKD) is one of the commonest monogenic disorders of man, affecting approximately 1 in 1000 of the world’s population. It is characterised by the progressive development and expansion of renal cysts, which eventually replace the normal architecture of the kidney and lead to kidney failure. (Harris 1999) ADPKD is a common cause of end-stage renal failure. It accounts for 5-8% of patients in haemodialysis units worldwide. It also has serious social and economic consequences. Of the UK National Health Service’s budget, 2% is spent on renal diseases. With 8% of renal patients on renal replacement programs in the UK having a diagnosis of ADPKD, this one disease commands considerable financial resources. University of Cambridge 2004-01-05 Thesis Doctoral Doctor of Philosophy (PhD) https://www.repository.cam.ac.uk/handle/1810/392873 https://www.repository.cam.ac.uk/bitstreams/7ac3d608-9248-4de3-9379-3a9750fb7a76/download e804754eb46ca4e5f39f1dc0c9379b34 https://www.repository.cam.ac.uk/bitstreams/bedc36bc-0fdd-44fa-83d3-25d4e9057039/download eb9d2d75cbfff5683a827dd2229be5c0 http://purl.org/NET/rdflicense/allrightsreserved/