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Radical methods for the synthesis of aliphatic amines 10.17863/CAM.64235 Flodén, Nils 0000000161794519 Gaunt, Matthew The aliphatic amine motif is a ubiquitous and uniquely important functional group in pharmaceutical agents and the development of ever more efficient synthetic methods for their synthesis is a continuous challenge. This thesis details the development of three new radical reactions for the synthesis of aliphatic amines. Following an introduction to radical chemistry and a summary of previous advances in amine synthesis, chapter 2 will describe a general carbonyl alkylative amination reaction, a successful version of which has been sought for over 70 years. Facilitated by visible light and a silane reducing agent, the operationally straightforward reaction forms tertiary amines via the coupling of aldehydes and secondary amines with alkyl halides. Combining an efficient radical-chain mechanism with the structural and functional diversity of readily available starting materials, the carbonyl alkylative amination provides a flexible strategy for the streamlined synthesis of complex tertiary amines. In chapter 3, an improved carbonyl alkylative amination was sought by replacing the alkyl halide with a more abundant radical precursor. This led to the development of a new carbonyl alkylative amination reaction using tetrachloro N-hydroxyphthalimide esters, prepared from carboxylic acids, in conjunction with inexpensive and environmentally friendly zinc dust instead of the costly silane reducing agent. The use of a carboxylic acid derived nucleophile enabled a broader scope in both amine and nucleophile components and the full potential of this reaction is currently being developed. In chapter 4, a visible light-mediated direct synthesis of N-heterospirocycles is reported. A photocatalyst was employed to reduce an aliphatic iminium ion to the corresponding -amino radical, which was cyclized to afford polar, heteroatom-rich spirocycles. The reaction tolerated a range of polar functional groups and the resulting scaffolds were shown to occupy a promising yet less exploited area of chemical space, making the reaction relevant for fragment-based drug discovery. University of Cambridge 2020-07-01 Thesis Doctoral Doctor of Philosophy (PhD) eng Gates Cambridge Foundation https://www.repository.cam.ac.uk/handle/1810/317125 https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/fc7bdeb3-422e-4707-9479-cae962257831/download c887455dd180980552d3953c6d92eac4 https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/00c143dc-326a-4d47-a000-1320d729518c/download 353adac0d1ebdfd65ab16480263c3c87 https://www.rioxx.net/licenses/all-rights-reserved/ Radicals Amines Photoredox Visible light