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Exploiting a novel organotypic model of SOX2-driven early squamous lung cancer to identify potential routes to chemoprevention 10.17863/CAM.50341 Barry, Philip Simon 0000000160316347 McCaughan, Frank Lung cancer is a devastating disease and is the leading cause of cancer related death globally. Squamous cell lung cancer (SQC) accounts for around 25% of all lung cancer diagnoses. Better strategies for the early detection, prevention and treatment of lung cancer are urgently needed. Using a novel in vitro model of SOX2-driven early SQC I performed a screen using tool compounds and compounds in late phase clinical development for potential efficacy in chemoprevention. I combined this approach with targeted genetic ablation studies to identify/characterise targets that may be key to the progression of SOX2-driven squamous cell carcinomas. In particular I highlight an AKT isoform dependence in SQC that could be exploited in future clinical chemoprevention studies. University of Cambridge 2020-03-21 Thesis Doctoral Doctor of Philosophy (PhD) en https://www.repository.cam.ac.uk/handle/1810/303261 https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/44e5cb87-5d0e-4526-9e3c-5fcf9dbd0e2a/download 91b89334b7e67849a138f9cb8d0e10ae https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/37f28e44-d168-44aa-9a53-4a4910e98842/download 87eda9de84448d1f82354d60eee3eb5f https://creativecommons.org/licenses/by-nc-nd/4.0/ lung cancer SOX2 squamous AKT3 chemoprevention squamous cell lung cancer