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Magnetic Resonance imaging of tumour biomarkers in ovarian cancer 10.17863/CAM.44734 Deen, Surrin Shazam Gallagher, Ferdia Brenton, James This thesis explores the application of novel magnetic resonance imaging (MRI) techniques to the evaluation of ovarian cancer. Diffusion kurtosis imaging (DKI), sodium MRI, magnetization transfer (MT) imaging, hyperpolarized carbon-13 MRI and magnetic resonance fingerprinting (MRF) were employed to image ovarian tumours in human subjects. The results of the imaging were compared to semi-quantitative measurements of histology and immunohistochemistry staining of tissue samples. It was found that DKI may predict responders to cytotoxic drugs and that sodium MRI and MT measure cellularity. Effective techniques to perform hyperpolarized carbon-13 MRI and MRF were also shown in a clinical setting, where MRF may improve imaging speed and the reproducibility of proton imaging and hyperpolarized carbon-13 MRI could provide unique in vivo metabolic information that differs from FDG-PET. University of Cambridge 2019-12-31 Thesis Doctoral Doctor of Philosophy (PhD) en Gates Cambridge Trust Cancer Research UK Wellcome Trust Cambridge Experimental Cancer Medicine Centre The Medical Research Council (MRC), Addenbrooke’s Charitable Trust https://www.repository.cam.ac.uk/handle/1810/297680 https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/dc837686-11d1-4453-87e6-cca67d8dbda4/download c2e043118650262990c4d2b0995305fa https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/b096fbe7-a94d-4f49-9936-38c96d2a3783/download 87eda9de84448d1f82354d60eee3eb5f https://creativecommons.org/licenses/by/4.0/ Magnetic resonance imaging ovarian cancer tumour biomarker