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<article article-type="research-article" dtd-version="1.1" xml:lang="en" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="publisher-id">PPJ</journal-id><journal-title-group><journal-title>Journal of Perioperative Practice</journal-title></journal-title-group><issn pub-type="ppub">1750-4589</issn><issn pub-type="epub">2515-7949</issn><publisher><publisher-name>SAGE Publications</publisher-name><publisher-loc>Sage UK: London, England</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1177/1750458920943361</article-id><article-id pub-id-type="publisher-id">10.1177_1750458920943361</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Massive blood loss protocol ‘Code Red’ at Papworth Hospital: A closed loop audit</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Tennyson</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff1-1750458920943361">1</xref><xref ref-type="corresp" rid="corresp1-1750458920943361"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3818-4717</contrib-id><name><surname>Redlaff</surname><given-names>J</given-names></name><xref ref-type="aff" rid="aff2-1750458920943361">2</xref></contrib><contrib contrib-type="author"><name><surname>Biosse-Duplan</surname><given-names>G</given-names></name><xref ref-type="aff" rid="aff2-1750458920943361">2</xref></contrib><contrib contrib-type="author"><name><surname>Lewin</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff3-1750458920943361">3</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>N</given-names></name><xref ref-type="aff" rid="aff4-1750458920943361">4</xref></contrib><contrib contrib-type="author"><name><surname>Layard Horsfall</surname><given-names>H</given-names></name><xref ref-type="aff" rid="aff5-1750458920943361">5</xref></contrib><aff id="aff1-1750458920943361"><label>1</label>Addenbrooke’s Hospital, Cambridge, UK</aff><aff id="aff2-1750458920943361"><label>2</label>School of Clinical Medicine, University of Cambridge, Cambridge, UK</aff><aff id="aff3-1750458920943361"><label>3</label>Department of Transfusion, Addenbrooke’s Hospital, Cambridge, UK</aff><aff id="aff4-1750458920943361"><label>4</label>Department of Cardiothoracic Anaesthesia and Critical Care Medicine, Papworth Hospital NHS Foundation Trust, Cambridge, UK</aff><aff id="aff5-1750458920943361"><label>5</label>Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke’s Hospital and University of Cambridge, Cambridge, UK</aff></contrib-group><author-notes><corresp id="corresp1-1750458920943361">M Tennyson, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK. Email: <email>mt607@cam.ac.uk</email></corresp></author-notes><pub-date pub-type="epub"><day>8</day><month>9</month><year>2020</year></pub-date><volume>31</volume><issue>9</issue><fpage>334</fpage><lpage>340</lpage><permissions><copyright-statement>© The Author(s) 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder content-type="society">Association for Perioperative Practice</copyright-holder><license><ali:license_ref start_date="2020-09-08" xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0/</ali:license_ref><license-p>This article is distributed under the terms of the Creative Commons Attribution 4.0 License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (<ext-link ext-link-type="uri" xlink:href="https://us.sagepub.com/en-us/nam/open-access-at-sage">https://us.sagepub.com/en-us/nam/open-access-at-sage</ext-link>).</license-p></license></permissions><abstract><sec><title>Aim</title><p>To investigate if the massive blood loss protocol ‘Code Red’ at a specialist cardiothoracic hospital was activated according to local and national guidelines by a closed loop audit.</p></sec><sec><title>Methods</title><p>Electronic and paper patient care systems were searched in 2015 and 2018 to access records for the ‘Code Red’ activations. Activation of the massive blood loss protocol was compared against the national standards set by The British Committee for Standards in Haematology. The percentage of cases meeting each of the ten standards in the specialist cardiac unit’s Protocol for the Management of Massive Blood Loss in Adults (adapted from the national standards) were evaluated.</p></sec><sec><title>Results</title><p>‘Code Red’ protocol was activated on 18 occasions in 2015 and nine occasions in 2018, representing just 0.83 and 0.26% of emergency surgeries, respectively. Between 2015 and 2018, there was a 6% increase of ‘Code Red’ cases being appropriately activated, a 26% increase in the prompt notification of the haematology department upon activation, alongside a 30% increase in the timely delivery of blood products, and a 25% decrease in the average amount of blood transferred prior to ‘Code Red’ activation.</p></sec><sec><title>Conclusion</title><p>There has been an improvement in the standards of care and management of massive blood loss this specialist cardiac centre despite the target timeframe being reduced from 30 to 15min between 2015 and 2018. Preparation for and anticipation of massive blood loss has likely decreased the number of incidences requiring ‘Code Red’ activation, permitting delivery of safe patient care.</p></sec></abstract><kwd-group><kwd>Massive blood loss</kwd><kwd>Intensive care</kwd><kwd>Transfusion</kwd><kwd>Cardiothoracic</kwd><kwd>Haemorrhage protocol transfusion</kwd><kwd>Massive haemorrhage</kwd><kwd>Audit</kwd><kwd>Quality improvement</kwd><kwd>Cardiothoracics</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>typesetter</meta-name><meta-value>ts2</meta-value></custom-meta></custom-meta-group></article-meta></front></article>