10.3390/nu13051468 Associations between Children’s Genetic Susceptibility to Obesity, Infant’s Appetite and Parental Feeding Practices in Toddlerhood http://orcid.org/0000-0002-5415-6954 Guivarch Claire Dr. Université de Paris, CRESS, INSERM, INRAE, F-75004 Paris, France claire.guivarch@inserm.fr http://orcid.org/0000-0003-4025-4390 Charles Marie-Aline Dr. Université de Paris, CRESS, INSERM, INRAE, F-75004 Paris, France Unité Mixte Inserm-Ined-EFS ELFE, Ined, F-75020 Paris, France marie-aline.charles@inserm.fr Forhan Anne Dr. Université de Paris, CRESS, INSERM, INRAE, F-75004 Paris, France anne.forhan@inserm.fr http://orcid.org/0000-0003-4689-7530 Ong Ken K. Dr. MRC Epidemiology Unit and Department of Paediatrics, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK Ken.Ong@mrc-epid.cam.ac.uk http://orcid.org/0000-0002-1565-1629 Heude Barbara Dr. Université de Paris, CRESS, INSERM, INRAE, F-75004 Paris, France barbara.heude@inserm.fr http://orcid.org/0000-0001-5887-8842 de Lauzon-Guillain Blandine Dr. Université de Paris, CRESS, INSERM, INRAE, F-75004 Paris, France blandine.delauzon@inserm.fr 26 04 2021 13 5 23 04 2021 e1468 Previous findings suggest that parental feeding practices may adapt to children’s eating behavior and sex, but few studies assessed these associations in toddlerhood. We aimed to study the associations between infant’s appetite or children’s genetic susceptibility to obesity and parental feeding practices. We assessed infant’s appetite (three-category indicator: low, normal or high appetite, labelled 4-to-24-month appetite) and calculated a combined obesity risk-allele score (genetic risk score of body mass index (BMI-GRS)) in a longitudinal study of respectively 1358 and 932 children from the EDEN cohort. Parental feeding practices were assessed at 2-year-follow-up by the CFPQ. Three of the five tested scores were used as continuous variables; others were considered as binary variables, according to the median. Associations between infant’s appetite or child’s BMI-GRS and parental feeding practices were assessed by linear and logistic regression models, stratified on child’s sex if interactions were significant. 4-to-24-month appetite was positively associated with restrictive feeding practices among boys and girls. Among boys, high compared to normal 4-to-24-month appetite was associated with higher use of food to regulate child’s emotions (OR [95% CI] = 2.24 [1.36; 3.68]). Child’s BMI-GRS was not related to parental feeding practices. Parental feeding practices may adapt to parental perception of infant’s appetite and child’s sex. © 1996-2021 MDPI (Basel, Switzerland) 2021 This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited parental feeding practices genetic susceptibility to obesity eating behavior birth cohort Nutrients Nutrients 2072-6643 MDPI