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<front>
<journal-meta>
<journal-id journal-id-type="doi">10.1002/(ISSN)1096-8644</journal-id>
<journal-id journal-id-type="publisher-id">AJPA</journal-id>
<journal-title-group>
<journal-title xml:lang="en">American Journal of Physical Anthropology</journal-title>
<abbrev-journal-title abbrev-type="publisher" xml:lang="en">Am J Phys Anthropol</abbrev-journal-title>
</journal-title-group>
<issn publication-format="ppub">0002-9483</issn>
<issn publication-format="epub">1096-8644</issn>
<publisher>
<publisher-name>John Wiley &amp; Sons, Inc.</publisher-name>
<publisher-loc>Hoboken, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.1002/ajpa.24217</article-id>
<article-id pub-id-type="publisher-id">AJPA24217</article-id>
<article-categories>
<subj-group subj-group-type="overline" xml:lang="en">
<subject>BRIEF COMMUNICATION</subject>
</subj-group>
<subj-group subj-group-type="heading" xml:lang="en">
<subject>BRIEF COMMUNICATIONS</subject>
</subj-group>
</article-categories>
<title-group>
<article-title xml:lang="en">A Novel method for the identification and quantification of weight faltering</article-title>
<alt-title alt-title-type="left-running-head">Naumenko et al.</alt-title>
</title-group>
<contrib-group>
<contrib id="ajpa24217-cr-0001" contrib-type="author">
<name>
<surname>Naumenko</surname>
<given-names>Daniel J.</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0001">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="ajpa24217-aff-0002">
<sup>2</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0002" contrib-type="author">
<name>
<surname>Dykes</surname>
<given-names>James</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0002">
<sup>2</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0003" contrib-type="author">
<name>
<surname>O'Connor</surname>
<given-names>G. Kesler</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0003">
<sup>3</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0004" contrib-type="author">
<name>
<surname>Stanley</surname>
<given-names>Zofia</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0003">
<sup>3</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0005" contrib-type="author">
<name>
<surname>Affara</surname>
<given-names>Nabeel</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0004">
<sup>4</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0006" contrib-type="author">
<name>
<surname>Doel</surname>
<given-names>Andrew M.</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0005">
<sup>5</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0007" contrib-type="author">
<name>
<surname>Drammeh</surname>
<given-names>Saikou</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0006">
<sup>6</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0008" contrib-type="author">
<name>
<surname>Dunger</surname>
<given-names>David B.</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0007">
<sup>7</sup>
</xref>
<xref ref-type="aff" rid="ajpa24217-aff-0008">
<sup>8</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0009" contrib-type="author">
<name>
<surname>Faal</surname>
<given-names>Abdoulie</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0006">
<sup>6</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0010" contrib-type="author">
<name>
<surname>Ong</surname>
<given-names>Ken K.</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0007">
<sup>7</sup>
</xref>
<xref ref-type="aff" rid="ajpa24217-aff-0009">
<sup>9</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0011" contrib-type="author">
<name>
<surname>Sosseh</surname>
<given-names>Fatou</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0006">
<sup>6</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0012" contrib-type="author">
<name>
<surname>Prentice</surname>
<given-names>Andrew M.</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0006">
<sup>6</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0013" contrib-type="author">
<name>
<surname>Moore</surname>
<given-names>Sophie E.</given-names>
</name>
<xref ref-type="aff" rid="ajpa24217-aff-0005">
<sup>5</sup>
</xref>
<xref ref-type="aff" rid="ajpa24217-aff-0006">
<sup>6</sup>
</xref>
</contrib>
<contrib id="ajpa24217-cr-0014" contrib-type="author" corresp="yes">
<name>
<surname>Bernstein</surname>
<given-names>Robin M.</given-names>
</name>
<contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8805-7527</contrib-id>
<email>robin.bernstein@colorado.edu</email>
<xref ref-type="corresp" rid="correspondenceTo">*</xref>
<xref ref-type="aff" rid="ajpa24217-aff-0001">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="ajpa24217-aff-0002">
<sup>2</sup>
</xref>
</contrib>
</contrib-group>
<aff id="ajpa24217-aff-0001">
<label>
<sup>1</sup>
</label>

<named-content content-type="organisation-division">Growth and Development Lab, Department of Anthropology</named-content>

<institution>University of Colorado Boulder</institution>

<city>Boulder</city>
 <named-content content-type="country-part">Colorado</named-content>
 <country country="US">USA</country>

</aff>
<aff id="ajpa24217-aff-0002">
<label>
<sup>2</sup>
</label>

<named-content content-type="organisation-division">Health and Society Program, Institute of Behavioral Science</named-content>

<institution>University of Colorado Boulder</institution>

<city>Boulder</city>
 <named-content content-type="country-part">Colorado</named-content>
 <country country="US">USA</country>

</aff>
<aff id="ajpa24217-aff-0003">
<label>
<sup>3</sup>
</label>

<named-content content-type="organisation-division">Department of Applied Mathematics</named-content>

<institution>University of Colorado Boulder</institution>

<city>Boulder</city>
 <named-content content-type="country-part">Colorado</named-content>
 <country country="US">USA</country>

</aff>
<aff id="ajpa24217-aff-0004">
<label>
<sup>4</sup>
</label>

<named-content content-type="organisation-division">Department of Pathology</named-content>

<institution>University of Cambridge</institution>

<city>Cambridge</city>
 <country country="GB">UK</country>

</aff>
<aff id="ajpa24217-aff-0005">
<label>
<sup>5</sup>
</label>

<named-content content-type="organisation-division">Department of Women and Children's Health</named-content>

<institution>King's College London</institution>

<city>London</city>
 <country country="GB">UK</country>

</aff>
<aff id="ajpa24217-aff-0006">
<label>
<sup>6</sup>
</label>

<institution>MRC Unit The Gambia at London School of Hygiene and Tropical Medicine</institution>

<city>Banjul</city>
 <country country="GM">Gambia</country>

</aff>
<aff id="ajpa24217-aff-0007">
<label>
<sup>7</sup>
</label>

<named-content content-type="organisation-division">Department of Paediatrics</named-content>

<institution>University of Cambridge School of Clinical Medicine</institution>

<city>Cambridge</city>
 <country country="GB">UK</country>

</aff>
<aff id="ajpa24217-aff-0008">
<label>
<sup>8</sup>
</label>

<named-content content-type="organisation-division">Institute of Metabolic Science</named-content>

<institution>Cambridge Biomedical Campus</institution>

<city>Cambridge</city>
 <country country="GB">UK</country>

</aff>
<aff id="ajpa24217-aff-0009">
<label>
<sup>9</sup>
</label>

<named-content content-type="organisation-division">MRC Epidemiology Unit</named-content>

<institution>University of Cambridge School of Clinical Medicine</institution>

<city>Cambridge</city>
 <country country="GB">UK</country>

</aff>
<author-notes>
<corresp id="correspondenceTo"><label>*</label>

<bold>Correspondence</bold><break/>
Robin M. Bernstein, Department of Anthropology,1350 Pleasant St, UCB 233 Boulder, CO 80309‐0233, USA.<break/>
Email: <email>robin.bernstein@colorado.edu</email>
<break/>

</corresp>
</author-notes>
<pub-date date-type="pub" publication-format="electronic"><day>01</day>
<month>01</month>
<year>2021</year>
</pub-date><pub-date date-type="pub" publication-format="print"><month>05</month>
<year>2021</year>
</pub-date><volume>175</volume>
<issue seq="190">1</issue>
<issue-id pub-id-type="doi">10.1002/ajpa.v175.1</issue-id>
<fpage>282</fpage>
<lpage>291</lpage>
<history>

<date date-type="rev-recd">
<day>16</day>
<month>11</month>
<year>2020</year>
</date>

<date date-type="received">
<day>06</day>
<month>05</month>
<year>2020</year>
</date>

<date date-type="accepted">
<day>13</day>
<month>12</month>
<year>2020</year>
</date>

</history>
<permissions>
<copyright-statement content-type="issue-copyright">© 2021 Wiley Periodicals LLC.</copyright-statement>
<copyright-statement content-type="article-copyright">© 2021 The Authors. <italic>American Journal of Physical Anthropology</italic> published by Wiley Periodicals LLC.</copyright-statement>
<copyright-year>2021</copyright-year>
<copyright-holder>© 2021 The Authors. American Journal of Physical Anthropology published by Wiley Periodicals LLC.</copyright-holder>
<license>
<ali:license_ref>http://creativecommons.org/licenses/by/4.0/</ali:license_ref>
<license-p>This is an open access article under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution</ext-link> License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract xml:lang="en" abstract-type="main">
<title>Abstract</title>
<sec id="ajpa24217-sec-0001" xml:lang="en">
<title>Objective</title>
<p xml:lang="en">We describe a new method for identifying and quantifying the magnitude and rate of short‐term weight faltering episodes, and assess how (a) these episodes relate to broader growth outcomes, and (b) different data collection intervals influence the quantification of weight faltering.</p>
</sec>
<sec id="ajpa24217-sec-0002" xml:lang="en">
<title>Materials and methods</title>
<p xml:lang="en">We apply this method to longitudinal growth data collected every other day across the first year of life in Gambian infants (<italic toggle="no">n</italic> = 124, males = 65, females = 59). Weight faltering episodes are identified from velocity peaks and troughs. Rate of weight loss and regain, maximum weight loss, and duration of each episode were calculated. We systematically reduced our dataset to mimic various potential measurement intervals, to assess how these intervals affect the ability to derive information about short‐term weight faltering episodes. We fit linear models to test whether metrics associated with growth faltering were associated with growth outcomes at 1 year, and generalized additive mixed models to determine whether different collection intervals influence episode identification and metrics.</p>
</sec>
<sec id="ajpa24217-sec-0003" xml:lang="en">
<title>Results</title>
<p xml:lang="en">Three hundred weight faltering episodes from 119 individuals were identified. The number and magnitude of episodes negatively impacted growth outcomes at 1 year. As data collection interval increases, weight faltering episodes are missed and the duration of episodes is overestimated, resulting in the rate of weight loss and regain being underestimated.</p>
</sec>
<sec id="ajpa24217-sec-0004" xml:lang="en">
<title>Conclusions</title>
<p xml:lang="en">This method identifies and quantifies short‐term weight faltering episodes, that are in turn negatively associated with growth outcomes. This approach offers a tool for investigators interested in understanding how short‐term weight faltering relates to longer‐term outcomes.</p>
</sec>
</abstract>
<kwd-group kwd-group-type="author-generated" xml:lang="en">
<kwd id="ajpa24217-kwd-0001">growth faltering</kwd>
<kwd id="ajpa24217-kwd-0002">infancy</kwd>
<kwd id="ajpa24217-kwd-0003">stunting</kwd>
<kwd id="ajpa24217-kwd-0004">the Gambia</kwd>
<kwd id="ajpa24217-kwd-0005">wasting</kwd>
</kwd-group>
<funding-group>
<award-group id="funding-0001">
<funding-source>

<institution-wrap>
<institution>Bill and Melinda Gates Foundation</institution>
<institution-id>http://dx.doi.org/10.13039/100000865</institution-id>
</institution-wrap>

</funding-source>
<award-id>OPP1066932</award-id>
</award-group>
</funding-group>
<funding-group>
<award-group id="funding-0002">
<funding-source>

<institution-wrap>
<institution>Medical Research Council</institution>
<institution-id>http://dx.doi.org/10.13039/501100007155</institution-id>
</institution-wrap>

</funding-source>
<award-id>MC‐A760‐5QX00</award-id>
</award-group>
</funding-group>
<counts>
<fig-count count="3"/>
<table-count count="2"/>
<page-count count="10"/>
<word-count count="8526"/>
</counts>
</article-meta>
</front>
</article>